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Agent skill

Joann E Manson

by K-Dense-AI in K-Dense-AI/mimeographs

A skill your agent uses to reason like JoAnn E. An agent skill from K-Dense-AI/mimeographs.

MITAuto-check passedResearch & Science

Install Joann E Manson

skills CLI
$ npx skills add K-Dense-AI/mimeographs --skill joann-e-manson -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install K-Dense-AI/mimeographs joann-e-manson --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeographs.git skills-src && mkdir -p .claude/skills && cp -r skills-src/mimeographs/joann-e-manson .claude/skills/joann-e-manson && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
joann-e-manson
GitHub stars
129
Token cost
~1.6k tokens
SKILL.md length
803 words
Files
72 (incl. references)
Skills in repo
60
Repo updated
First seen
Licence
MIT

At a glance

A skill your agent uses to reason like JoAnn E. An agent skill from K-Dense-AI/mimeographs.

  • Works in 5 steps: Confirm moderate-to-severe vasomotor… → Assess age and time since menopause… → Check for an intact uterus to determine… → …
  • Reason like JoAnn E
  • SKILL.md covers Core principles, How JoAnn E. Manson reasons, Applying the frameworks and Anti-patterns she pushes against, plus 1 more section
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Joann E Manson is an agent skill from K-Dense-AI/mimeographs. Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention…

Its SKILL.md is about 1.6k tokens, which your agent loads only when the skill is triggered. The skill folder holds 74 other files, including reference files (for example `AGENTS.md`, `_workspace/agents_output.e584bd6c.json` and `_workspace/clustered_corpus.e584bd6c.json`).

It sits in Research & Science, covering Clinical and healthcare research. The repository describes itself as: Ready-to-use agent skills that clone the thinking of founders, philosophers, and scientists into your agent. Generated with K-Dense-AI/mimeo. The licence is MIT.

When your agent uses it

  • Reason like JoAnn E
  • This skill whenever you are evaluating hormone replacement therapy (HRT)
  • Menopause management
  • Nutritional epidemiology

Example prompts

  • “/joann-e-manson”

Workflow steps

5 steps, taken from the first numbered list in SKILL.md.

  1. Confirm moderate-to-severe vasomotor symptoms that impair quality of life.
  2. Assess age and time since menopause (ideal: <60 years old, <10 years since onset).
  3. Check for an intact uterus to determine if a progestogen is required.
  4. Evaluate baseline cardiovascular, blood clot, and breast cancer risks.
  5. Select the lowest effective dose and formulation (e.g., transdermal for metabolic syndrome) for the shortest necessary duration.

What it can do on your machine

Read from SKILL.md and the folder at commit a38f5fc. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md.

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Joann E Manson loads about 1.6k tokens when it runs, and up to ~6.6k if it reads all its reference files. Until then it costs about 160 tokens; SKILL.md has 803 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~160
When it runs · the whole SKILL.md, loaded when a task matches
~1.6k
With references · SKILL.md plus every file in references/, read only if the agent opens them
~6.6k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

The full file from K-Dense-AI/mimeographs at commit a38f5fc, republished under its MIT licence (© K-Dense-AI). 803 words, ~1,647 tokens.

Download SKILL.mdSave it as .claude/skills/joann-e-manson/SKILL.md (or your agent's skills folder). This skill also uses 71 other files; get the full folder from GitHub.
name
joann-e-manson
description
Use this skill to reason like JoAnn E. Manson, epidemiologist at Harvard Medical School and women's health expert. Trigger this skill whenever you are evaluating hormone replacement therapy (HRT), menopause management, nutritional epidemiology, dietary supplements, or clinical trial methodology. Apply her frameworks when users ask about the risks and benefits of HRT, bioidentical hormones, or targeted supplementation. Reach for this skill to differentiate between symptom management and chronic disease prevention, or when assessing observational data versus randomized clinical trials (RCTs) in public health contexts.

Thinking like JoAnn E. Manson

JoAnn E. Manson is a pioneering epidemiologist at Harvard Medical School whose work fundamentally reshaped our understanding of women's health, hormone therapy, and preventive medicine. Her thinking is defined by a rigorous commitment to randomized clinical trials (RCTs) over observational data, a precision-medicine approach to risk stratification, and a clear demarcation between treating acute symptoms and preventing chronic disease.

Reach for this skill whenever you're evaluating the risks and benefits of medical interventions (especially HRT or supplements), navigating menopause management, or analyzing epidemiological evidence.

Core principles

  • HRT for Symptom Relief, Not Prevention: Prescribe hormone therapy for the short-term relief of moderate-to-severe menopausal symptoms, but never for the prevention of chronic diseases like cardiovascular disease or dementia.
  • The Timing Hypothesis: Evaluate the absolute risks of hormone therapy based on the timing of initiation relative to the onset of menopause, as early intervention carries vastly different cardiovascular implications than late intervention.
  • Individualized Menopause Management: Reject one-size-fits-all solutions; personalize treatment based on a woman's age, time since menopause, and baseline health risks.
  • Observational Studies vs. RCTs: Treat observational studies as hypothesis generators, but demand randomized clinical trials to prove causality and eliminate confounding factors like healthy user bias.
  • Diet First, Supplements for Gaps: Prioritize a predominantly plant-based diet and use dietary supplements only to fill specific, identified nutritional gaps rather than as universal prescriptions.

For detailed rationale and quotes, see references/principles.md.

How JoAnn E. Manson reasons

Manson evaluates medical interventions through a strict epidemiological lens, constantly asking: Is this evidence from an observational study or a randomized clinical trial? She is highly attuned to Observational Confounding (Healthy User Bias), recognizing that people who take preventive treatments (like early HRT or vitamins) often have healthier baseline behaviors that skew observational data.

When weighing treatments, she applies The High Bar for Prevention: a conceptual threshold dictating that drugs used broadly for chronic disease prevention in asymptomatic people must have exceptionally low risks, whereas drugs used for immediate symptom management can tolerate a slightly higher risk profile. In women's health specifically, her reasoning is anchored by The Timing Hypothesis (Critical Window), which dictates that the biological effects of an intervention (like estrogen) depend fundamentally on the age and baseline health of the patient's vascular system at the time of initiation.

For a full catalog of her analytical lenses, see references/mental-models.md.

Applying the frameworks

HRT Clinical Decision-Making Algorithm

Use this when evaluating a menopausal woman as a candidate for systemic hormone therapy.

  1. Confirm moderate-to-severe vasomotor symptoms that impair quality of life.
  2. Assess age and time since menopause (ideal: <60 years old, <10 years since onset).
  3. Check for an intact uterus to determine if a progestogen is required.
  4. Evaluate baseline cardiovascular, blood clot, and breast cancer risks.
  5. Select the lowest effective dose and formulation (e.g., transdermal for metabolic syndrome) for the shortest necessary duration.
Show full SKILL.md (327 more words)Show less
Targeted Nutritional Supplementation Strategy

Use this when a user asks about taking vitamins or dietary supplements.

  1. Assess the baseline diet to identify specific nutritional gaps.
  2. Recommend targeted supplements only for deficits that cannot be met through diet alone.
  3. Ensure supplements carry a quality control seal (like USP).
  4. Avoid mega-dosing, as excess amounts provide no additional benefit and can be harmful.

For the full catalog, including the STRAW+10 Classification Application, see references/frameworks.md.

Anti-patterns she pushes against

  • Prescribing HRT for Chronic Disease Prevention: Never use hormone therapy to prevent cardiovascular disease or dementia; the overall health risks outweigh the benefits.
  • Assuming Bioidentical Hormones are Safer: Do not assume custom-compounded 'bioidentical' hormones are safer than FDA-approved therapies; they lack large-scale clinical trial evidence and FDA oversight.
  • Estrogen Alone with an Intact Uterus: Never prescribe estrogen alone to a woman with an intact uterus; a progestogen must be included to prevent endometrial cancer.
  • Mega-dosing Supplements: Do not take excess amounts of dietary supplements assuming more is better; they should fill gaps, not replace a healthy diet.
  • Biomarker Reliance for Perimenopause: Do not rely primarily on FSH and estradiol levels to diagnose perimenopause, as they exhibit extreme intraindividual variability.

How to use this skill in conversation

When a user asks about menopause, hormone therapy, or dietary supplements, channel Manson's rigorous, evidence-based approach. Surface the relevant principle or framework by name (e.g., "JoAnn E. Manson's Timing Hypothesis suggests...").

If a user asks if they should take HRT to protect their heart, firmly apply the HRT for Symptom Relief, Not Prevention principle and explain the High Bar for Prevention mental model. If they ask about a new observational study claiming a vitamin cures a disease, invoke Observational Confounding and explain why an RCT is necessary. Always guide them toward the Lowest Effective Dose and individualized risk stratification. Do not pretend to be JoAnn E. Manson; instead, apply her frameworks to the user's specific context to provide clear, scientifically grounded guidance.

© K-Dense-AI, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file

Files

SKILL.md and 71 other files (references) in mimeographs/joann-e-manson of K-Dense-AI/mimeographs.

  • SKILL.md
  • AGENTS.md
  • _workspace/agents_output.e584bd6c.json
  • _workspace/clustered_corpus.e584bd6c.json
  • _workspace/discovery/books.json
  • _workspace/discovery/essays.json
  • _workspace/discovery/frameworks.json
  • _workspace/discovery/interviews.json
  • _workspace/discovery/letters.json
  • _workspace/discovery/papers.json
  • _workspace/discovery/podcasts.json
  • _workspace/discovery/ranked_sources.e584bd6c.json
  • _workspace/discovery/talks.json
  • _workspace/distilled/src_000.e584bd6c.json
  • _workspace/distilled/src_001.e584bd6c.json
  • _workspace/distilled/src_002.e584bd6c.json
  • _workspace/distilled/src_003.e584bd6c.json
  • _workspace/distilled/src_005.e584bd6c.json
  • … and 54 more

Open the folder on GitHubat commit a38f5fc

Compare with similar skills

Joann E Manson next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Joann E Manson compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
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CHARLS Paper Reproduction Guidexjtulyc/MedgeClaw6171 repos~1.8kAutomated safety check: PassNone
Biomedical Analysis Dispatchxjtulyc/MedgeClaw6171 repos~2kAutomated safety check: PassNone
Research Paperluwill/research-skills860—~1.9kAutomated safety check: PassNone
Research Proposalluwill/research-skills860—~4.5kAutomated safety check: NotesNone

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Categories

Questions about Joann E Manson

What does Joann E Manson do?

A skill your agent uses to reason like JoAnn E. An agent skill from K-Dense-AI/mimeographs. Joann E Manson is an agent skill from K-Dense-AI/mimeographs. Use this skill to reason like JoAnn E.

When should I use Joann E Manson?

Joann E Manson fits situations like: reason like JoAnn E; this skill whenever you are evaluating hormone replacement therapy (HRT); menopause management; nutritional epidemiology.

How do I install Joann E Manson in Claude Code?

Run `npx skills add K-Dense-AI/mimeographs --skill joann-e-manson -a claude-code`. Or copy the skill folder (mimeographs/joann-e-manson in K-Dense-AI/mimeographs) into .claude/skills/joann-e-manson in your project. Claude Code loads it when a task matches its description.

How do I install Joann E Manson in Codex?

Run `npx skills add K-Dense-AI/mimeographs --skill joann-e-manson -a codex`. Or copy the skill folder (mimeographs/joann-e-manson in K-Dense-AI/mimeographs) into .agents/skills/joann-e-manson in your project. Codex loads it when a task matches its description.

Can I use Joann E Manson in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add K-Dense-AI/mimeographs --skill joann-e-manson -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/joann-e-manson, .gemini/skills/joann-e-manson, .github/skills/joann-e-manson and .opencode/skills/joann-e-manson in your project.

What does Joann E Manson need to run?

SKILL.md names no scripts, command-line tools or credentials: Joann E Manson is instructions for the agent only.

Does Joann E Manson access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Joann E Manson safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Joann E Manson use?

Joann E Manson is published under the MIT licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.

How many tokens does Joann E Manson use?

About 1.6k tokens (SKILL.md is roughly 6.6k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full. Its references folder adds about 5k tokens, read only when the agent opens those files.

What are the alternatives to Joann E Manson?

Skills that share tags, products or a category with Joann E Manson: Clinical Trials Database (google-deepmind/science-skills, 3.2k stars), CHARLS Paper Reproduction Guide (xjtulyc/MedgeClaw, 617 stars), Biomedical Analysis Dispatch (xjtulyc/MedgeClaw, 617 stars) and Research Paper (luwill/research-skills, 860 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Joann E Manson?

K-Dense-AI (a GitHub organization) maintains it in K-Dense-AI/mimeographs, which has 129 GitHub stars. The repository holds 60 skills in this directory. The repository was last updated on August 18, 2026.

Source: K-Dense-AI/mimeographs on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.