SQL Optimization Patterns
ynulihao/AgentSkillOS
Master SQL query optimization, indexing strategies, and EXPLAIN analysis to dramatically improve database performance and eliminate slow queries.
Agent skill
Bio Clinical Databases Tumor Mutational Burden
by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds.
Install Bio Clinical Databases Tumor Mutational Burden
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burden --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .claude/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .claude/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burdenType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burden --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .agents/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .agents/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .agents/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burden --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .cursor/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .cursor/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git --path skills/bio-clinical-databases-tumor-mutational-burden--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burden --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .gemini/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .gemini/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burdenInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .github/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .github/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .github/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-tumor-mutational-burden --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/skills/bio-clinical-databases-tumor-mutational-burden .opencode/skills/bio-clinical-databases-tumor-mutational-burden && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "bio-clinical-databases-tumor-mutational-burden" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-clinical-databases-tumor-mutational-burden into .opencode/skills/bio-clinical-databases-tumor-mutational-burden/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-clinical-databases-tumor-mutational-burden", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
Facts
- Skill name
bio-clinical-databases-tumor-mutational-burden- GitHub stars
- 3.1k
- Token cost
- ~2.3k tokens
- SKILL.md length
- 351 words
- Files
- 3
- Skills in repo
- 279
- Repo updated
- First seen
- Licence
- None found
At a glance
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds.
- Assessing immunotherapy eligibility
- SKILL.md covers Version Compatibility, TMB Calculation from VCF…, Panel-Specific TMB (Ensembl… and TMB with Variant Filtering…, plus 5 more sections
- Runs Python scripts from its folder; calls pip
- Characterizing tumor immunogenicity
What it does
Bio Clinical Databases Tumor Mutational Burden is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Use when assessing immunotherapy eligibility or characterizing tumor immunogenicity.
Its SKILL.md is about 2.3k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/tmb_calculation.py` and `usage-guide.md`).
It sits in Databases, covering Database schema design. It works with Ensembl. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.
When your agent uses it
- Assessing immunotherapy eligibility
- Characterizing tumor immunogenicity
Example prompts
- “/bio-clinical-databases-tumor-mutational-burden”
Requirements
- Python 3
What it can do on your machine
Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.
Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
Ships script files (Python), which the agent can run.
Shell commands in SKILL.md call:
pip
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md. Its commands use pip, which can reach the network depending on how they are called.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Context cost
Bio Clinical Databases Tumor Mutational Burden loads about 2.3k tokens when it runs. Until then it costs about 60 tokens; SKILL.md has 351 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
Safety
Auto-check passed
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
SKILL.md
Without a licence we can't republish the file, so here is its outline and opening line. It has 351 words (~2,318 tokens).
“Reference examples tested with: Ensembl VEP 111+, SnpEff 5.2+, pandas 2.2+”
- name
- bio-clinical-databases-tumor-mutational-burden
- tool_type
- python
- primary_tool
- cyvcf2
Files
SKILL.md and 2 other files in skills/bio-clinical-databases-tumor-mutational-burden of FreedomIntelligence/OpenClaw-Medical-Skills.
- SKILL.md
- examples/tmb_calculation.py
- usage-guide.md
Open the folder on GitHubat commit b1f9b6e
Compare with similar skills
Bio Clinical Databases Tumor Mutational Burden next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Bio Clinical Databases Tumor Mutational Burden this skillFreedomIntelligence/OpenClaw-Medical-Skills | 3.1k | — | ~2.3k | Automated safety check: Pass | None | |
| SQL Optimization Patternsynulihao/AgentSkillOS | 618 | 11 repos | ~3.3k | Automated safety check: Pass | None | |
| Datamodellmnimbalyst/nimbalyst | 1.9k | — | ~713 | Automated safety check: Pass | MIT | |
| Add Mpk Taskmirage-project/mirage | 2.5k | — | ~4.5k | Automated safety check: Pass | Apache-2.0 | |
| B200 Flash Attention4 Plannermirage-project/mirage | 2.5k | — | ~1.9k | Automated safety check: Pass | Apache-2.0 | |
| Experiment Auditwanshuiyin/Auto-claude-code-research-in-sleep | 17k | 1 repos | ~2.7k | Automated safety check: Notes | MIT |
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B200 Flash Attention4 Planner
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A skill your agent uses when the user wants to design or extend a FlashAttention-style forward kernel on B200/Blackwell, involving the two MMAs QKᵀ and PV, online softmax, S/P/O in TMEM, warp roles…
Experiment Audit
wanshuiyin/Auto-claude-code-research-in-sleep
Audit experiment integrity before claiming results. An agent skill from wanshuiyin/Auto-claude-code-research-in-sleep.
Sqlite Schema Design
fastrepl/anarlog
Design or review schemas for crates/cloudsync using SQLite Sync constraints, not generic SQLite advice.
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Related
Works with
Categories
Questions about Bio Clinical Databases Tumor Mutational Burden
What does Bio Clinical Databases Tumor Mutational Burden do?
Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Bio Clinical Databases Tumor Mutational Burden is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds.
When should I use Bio Clinical Databases Tumor Mutational Burden?
Bio Clinical Databases Tumor Mutational Burden fits situations like: assessing immunotherapy eligibility; characterizing tumor immunogenicity.
How do I install Bio Clinical Databases Tumor Mutational Burden in Claude Code?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a claude-code`. Or copy the skill folder (skills/bio-clinical-databases-tumor-mutational-burden in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-clinical-databases-tumor-mutational-burden in your project. Claude Code loads it when a task matches its description.
How do I install Bio Clinical Databases Tumor Mutational Burden in Codex?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a codex`. Or copy the skill folder (skills/bio-clinical-databases-tumor-mutational-burden in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-clinical-databases-tumor-mutational-burden in your project. Codex loads it when a task matches its description.
Can I use Bio Clinical Databases Tumor Mutational Burden in Cursor, Gemini CLI or GitHub Copilot?
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-tumor-mutational-burden -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-clinical-databases-tumor-mutational-burden, .gemini/skills/bio-clinical-databases-tumor-mutational-burden, .github/skills/bio-clinical-databases-tumor-mutational-burden and .opencode/skills/bio-clinical-databases-tumor-mutational-burden in your project.
What does Bio Clinical Databases Tumor Mutational Burden need to run?
Going by SKILL.md and its folder, Bio Clinical Databases Tumor Mutational Burden needs Python for the scripts in its folder and the command-line tools its instructions call (pip). Our summary lists: Python 3.
Does Bio Clinical Databases Tumor Mutational Burden access the network?
SKILL.md contains no URLs. Its commands use pip, which can reach the network depending on how they are called. This is read from the text; nothing was executed.
Is Bio Clinical Databases Tumor Mutational Burden safe to install?
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
What licence does Bio Clinical Databases Tumor Mutational Burden use?
No licence was found for Bio Clinical Databases Tumor Mutational Burden or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.
How many tokens does Bio Clinical Databases Tumor Mutational Burden use?
About 2.3k tokens (SKILL.md is roughly 9.3k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.
What are the alternatives to Bio Clinical Databases Tumor Mutational Burden?
Skills that share tags, products or a category with Bio Clinical Databases Tumor Mutational Burden: SQL Optimization Patterns (ynulihao/AgentSkillOS, 618 stars), Datamodellm (nimbalyst/nimbalyst, 1.9k stars), Add Mpk Task (mirage-project/mirage, 2.5k stars) and B200 Flash Attention4 Planner (mirage-project/mirage, 2.5k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
Who maintains Bio Clinical Databases Tumor Mutational Burden?
FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,053 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.
Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.