Target Novelty Scorer

Source: https://github.com/aipoch/medical-research-skills

Target Novelty Scorer

ID: 177

When to Use

• Use this skill when the task needs Score the novelty of biological targets through literature mining and.
• Use this skill for evidence insight tasks that require explicit assumptions, bounded scope, and a reproducible output format.
• Use this skill when you need a documented fallback path for missing inputs, execution errors, or partial evidence.

Key Features

See ## Features above for related details.

• Scope-focused workflow aligned to: Score the novelty of biological targets through literature mining and.
• Packaged executable path(s): scripts/main.py.
• Reference material available in references/ for task-specific guidance.
• Structured execution path designed to keep outputs consistent and reviewable.

Dependencies

• Python 3.9+
• requests
• pandas
• biopython (Entrez API)
• numpy

Example Usage

See ## Usage above for related details.

cd "20260318/scientific-skills/Evidence Insight/target-novelty-scorer"
python -m py_compile scripts/main.py
python scripts/main.py --help

Example run plan:

1. Confirm the user input, output path, and any required config values.
2. Edit the in-file CONFIG block or documented parameters if the script uses fixed settings.
3. Run python scripts/main.py with the validated inputs.
4. Review the generated output and return the final artifact with any assumptions called out.

Implementation Details

See ## Workflow above for related details.

• Execution model: validate the request, choose the packaged workflow, and produce a bounded deliverable.
• Input controls: confirm the source files, scope limits, output format, and acceptance criteria before running any script.
• Primary implementation surface: scripts/main.py.
• Reference guidance: references/ contains supporting rules, prompts, or checklists.
• Parameters to clarify first: input path, output path, scope filters, thresholds, and any domain-specific constraints.
• Output discipline: keep results reproducible, identify assumptions explicitly, and avoid undocumented side effects.

Quick Check

Use this command to verify that the packaged script entry point can be parsed before deeper execution.

python -m py_compile scripts/main.py

Audit-Ready Commands

Use these concrete commands for validation. They are intentionally self-contained and avoid placeholder paths.

python -m py_compile scripts/main.py
python scripts/main.py --help

Workflow

1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work.
2. Validate that the request matches the documented scope and stop early if the task would require unsupported assumptions.
3. Use the packaged script path or the documented reasoning path with only the inputs that are actually available.
4. Return a structured result that separates assumptions, deliverables, risks, and unresolved items.
5. If execution fails or inputs are incomplete, switch to the fallback path and state exactly what blocked full completion.

Description

Score the novelty of biological targets based on literature mining. By analyzing literature in academic databases such as PubMed and PubMed Central, assess the research popularity, uniqueness, and innovation potential of target molecules in the research field.

Features

• 🔬 Literature Retrieval: Automatically retrieve literature related to targets from PubMed and other databases
• 📊 Novelty Scoring: Calculate target novelty score based on multi-dimensional indicators (0-100)
• 📈 Trend Analysis: Analyze temporal trends in target research
• 🧬 Cross-validation: Verify current research status of targets by combining multiple databases
• 📝 Report Generation: Generate detailed novelty analysis reports

Scoring Criteria

1. Research Heat (0-25 points): Number of related publications and citations in recent years
2. Uniqueness (0-25 points): Distinction from known popular targets
3. Research Depth (0-20 points): Progress of preclinical/clinical research
4. Collaboration Network (0-15 points): Diversity of research institutions/teams
5. Temporal Trend (0-15 points): Research growth trends in recent years

Usage

Basic Usage

cd /Users/z04030865/.openclaw/workspace/skills/target-novelty-scorer
python scripts/main.py --target "PD-L1"

Advanced Options

python scripts/main.py \
  --target "BRCA1" \
  --db pubmed \
  --years 10 \
  --output report.json \
  --format json

Parameters

Output Format

JSON Output

{
  "target": "PD-L1",
  "novelty_score": 72.5,
  "confidence": 0.85,
  "breakdown": {
    "research_heat": 18.5,
    "uniqueness": 20.0,
    "research_depth": 15.2,
    "collaboration": 12.0,
    "trend": 6.8
  },
  "metadata": {
    "total_papers": 15234,
    "recent_papers": 3421,
    "clinical_trials": 89,
    "analysis_date": "2026-02-06"
  },
  "interpretation": "This target has moderate novelty, with moderate research heat in recent years..."
}

API Requirements

• NCBI API Key (for PubMed retrieval)
• Optional: Europe PMC API

Installation

pip install -r requirements.txt

License

MIT License - Part of OpenClaw Bioinformatics Skills Collection