Alphagenome Single Variant Analysis
google-deepmind/science-skills
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API.
A skill your agent uses when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score…
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysis --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .claude/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .claude/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysisType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysis --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .agents/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .agents/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .agents/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysis --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .cursor/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .cursor/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/aipoch/medical-research-skills.git --path 'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis'--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysis --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .gemini/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .gemini/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysisInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .github/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .github/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .github/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install aipoch/medical-research-skills ssgsea-immune-infiltration-analysis --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/aipoch/medical-research-skills.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/'awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis' .opencode/skills/ssgsea-immune-infiltration-analysis && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "ssgsea-immune-infiltration-analysis" agent skill from https://github.com/aipoch/medical-research-skills/tree/main/awesome-med-research-skills/Data%20Analysis/ssgsea-immune-infiltration-analysis into .opencode/skills/ssgsea-immune-infiltration-analysis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ssgsea-immune-infiltration-analysis", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
ssgsea-immune-infiltration-analysisA skill your agent uses when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score…
Ssgsea Immune Infiltration Analysis is an agent skill from aipoch/medical-research-skills. Use when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score visualizations. NOT for single-cell RNA-seq, absolute cell proportion estimation, or clinical decision making.
Its SKILL.md is about 1.7k tokens, which your agent loads only when the skill is triggered. The skill folder holds 20 other files, including scripts and reference files (for example `eval_report_ssgsea-immune-infiltration-analysis_result.json`, `references/algorithm.md` and `references/cli-guide.md`).
It sits in Research & Science, covering Bioinformatics. The repository describes itself as: Hundreds of agent skills for medical research, including protocol design, data analysis, evidence insights, and academic writing. The licence is MIT.
4 steps, taken from the first numbered list in SKILL.md.
Read from SKILL.md and the folder at commit 686e09d. It shows what the files ask for, not the result of running them.
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Ships 8 files in scripts/ (R), which the agent can run.
From the folder's file list and the shell code blocks in SKILL.md.
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Ssgsea Immune Infiltration Analysis loads about 1.7k tokens when it runs, and up to ~4.5k if it reads all its reference files. Until then it costs about 80 tokens; SKILL.md has 624 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); the scripts in this folder are not scanned.
The full file from aipoch/medical-research-skills at commit 686e09d, republished under its MIT licence (© aipoch). 624 words, ~1,740 tokens.
.claude/skills/ssgsea-immune-infiltration-analysis/SKILL.md (or your agent's skills folder). This skill also uses 16 other files; get the full folder from GitHub.scripts/main.R with the target case and control groups.run_record.txt, output_manifest.txt, and the generated tables or plots.references/troubleshooting.md before retrying.| Situation | File to Read | Purpose |
|---|---|---|
| Need to run the analysis | scripts/main.R | CLI entry point |
| Need algorithm details | references/algorithm.md | Method assumptions and interpretation |
| Encounter an error | references/troubleshooting.md | Error codes and fixes |
| Need CLI examples or baseline execution details | references/cli-guide.md | Examples and recorded run details |
| Need dependency declarations | DESCRIPTION | Package list and Bioconductor source note |
| Need test commands | tests/run_tests.R | End-to-end test entry |
Rscript scripts/main.R \
--input_file ./expression_matrix.csv \
--group_file ./group_info.csv \
--gene_set ./immune_gene_sets.csv \
--case_group treatment \
--control_group control \
--output_dir ./output \
--method ssgsea \
--seed 42Validated path note:
ssgsea is the default validated path.gsva is supported, but only with kernels validated in the local GSVA environment.gsva with Gaussian completed successfully and is the documented baseline.| Short | Long | Type | Default | Description |
|---|---|---|---|---|
-i | --input_file | file | required | Expression matrix with genes as rows and samples as columns |
-g | --group_file | file | required | Group annotation table |
-e | --gene_set | file | tests/data/immune_gene_sets.csv | Immune gene-set CSV |
-a | --case_group | string | required | Case group label |
-b | --control_group | string | required | Control group label |
-o | --output_dir | dir | ./output | Output directory |
-m | --method | string | ssgsea | GSVA method: ssgsea, gsva |
-k | --kcdf | string | Gaussian | Kernel mode: Gaussian, Poisson; Gaussian is the validated GSVA baseline |
-n | --min_sz | integer | 2 | Minimum overlap genes per gene set |
-x | --max_sz | integer | 10000 | Maximum genes per gene set |
-p | --parallel_sz | integer | 2 | Requested parallel CPU count |
-u | --tau | numeric | 0.25 | Tau parameter for ssGSEA |
-d | --mx_diff | boolean | true | GSVA mx.diff switch |
-c | --gene_id_case | string | upper | Gene ID normalization: asis, upper, lower |
-s | --seed | integer | 42 | Random seed |
-t | --timeout_seconds | integer | 0 | Optional timeout; 0 disables it |
--sample_col | string/int | none | Sample column name or 1-based index | |
--group_col | string/int | none | Group column name or 1-based index | |
--make_plots | boolean | true | Generate PDF plots | |
--verbose | boolean | true | Print progress logs |
CSV or TSV. The first column must contain gene identifiers. Remaining columns are sample-level numeric expression values.
gene,Sample1,Sample2,Sample3
TP53,10.2,8.5,9.1
CXCL9,4.3,6.1,5.7CSV or TSV with at least one sample column and one group column.
sample,group
Sample1,control
Sample2,treatment
Sample3,treatmentCSV with gene and cell_type; immunity_class is optional.
gene,cell_type,immunity_class
CXCL9,Activated CD8 T cell,Adaptive
CD3D,Activated CD8 T cell,Adaptive| File | Description |
|---|---|
data/ssgsea_list.rds | Serialized analysis result object |
table/ssgsea_scores_long.csv | Long-format immune infiltration scores |
table/ssgsea_scores_wide.csv | Wide-format immune infiltration score matrix |
table/ssgsea_group_compare.csv | Case-vs-control comparison summary |
table/immune_cell_correlation_matrix.csv | Immune-cell Spearman correlation matrix |
table/immune_cell_correlation_pvalue.csv | Correlation p-value matrix |
plot/immune_cell_composition_sample.pdf | Sample-level composition plot; generated only when --make_plots=true |
plot/immune_group_boxplot.pdf | Group comparison boxplot; generated only when --make_plots=true |
plot/immune_correlation_heatmap.pdf | Immune-cell correlation heatmap; generated only when --make_plots=true |
plot/gene_immune_correlation_scatter_*.pdf | Auto-selected gene-vs-cell scatter plot; generated only when --make_plots=true |
run_record.txt | Structured execution record |
output_manifest.txt | Output file manifest with descriptions |
session_info.txt | R session information |
| Error | Cause | Solution |
|---|---|---|
SKILL_FILE_NOT_FOUND | Input file path is invalid | Check file paths |
SKILL_MISSING_COLUMNS | Required columns are absent | Fix the input schema |
SKILL_EMPTY_DATA | No usable rows, gene sets, or aligned samples remain | Check IDs and filters |
SKILL_INVALID_PARAMETER | CLI value is invalid or data is malformed | Review arguments and file content |
SKILL_SAMPLE_MISMATCH | Expression and group samples do not align | Harmonize sample identifiers |
SKILL_PACKAGE_NOT_FOUND | Required R package is missing | Install the missing package |
SKILL_TIMEOUT | The configured time limit was exceeded | Increase --timeout_seconds or disable it with 0 |
Rscript scripts/main.R --help
Rscript tests/run_tests.R
Rscript tests/test_skill.Rtests/test_skill.R is self-contained: if expected outputs are absent, it first runs tests/run_tests.R and then validates both file presence and core result structure.
© aipoch, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file
SKILL.md and 16 other files (scripts, references) in awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis of aipoch/medical-research-skills.
Open the folder on GitHubat commit 686e09d
Ssgsea Immune Infiltration Analysis next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Ssgsea Immune Infiltration Analysis this skillaipoch/medical-research-skills | 1.9k | — | ~1.7k | Automated safety check: Pass | MIT | |
| Alphagenome Single Variant Analysisgoogle-deepmind/science-skills | 3.2k | 2 repos | ~3k | Automated safety check: Notes | Apache-2.0 | |
| 13C Metabolic Flux AnalysisK-Dense-AI/scientific-agent-skills | 48k | 1 repos | ~3.2k | Automated safety check: Pass | MIT | |
| Clinvar Databasegoogle-deepmind/science-skills | 3.2k | 2 repos | ~3.9k | Automated safety check: Notes | Apache-2.0 | |
| Metabolic Study Planneraiming-lab/AutoResearchClaw | 15k | — | ~1.9k | Automated safety check: Pass | MIT | |
| Dbsnp Databasegoogle-deepmind/science-skills | 3.2k | 2 repos | ~3.4k | Automated safety check: Notes | Apache-2.0 |
google-deepmind/science-skills
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API.
K-Dense-AI/scientific-agent-skills
Estimates reaction fluxes inside cells from steady-state carbon-13 labeling data with a bundled mfapy-based solver, and reports which fluxes the data pin down.
google-deepmind/science-skills
A skill your agent uses when needing clinical significance, pathogenicity classifications (e.g., Pathogenic, Benign, VUS), clinical evidence rationales, or finding "hard positive" benchmark controls…
aiming-lab/AutoResearchClaw
Turns a broad metabolic modelling topic into a concrete, paper-shaped plan with organism, model, perturbations, metrics and figures before any FBA code is written.
google-deepmind/science-skills
A skill your agent uses when you want to look up, map, and search for short genetic variants (SNPs, indels) in NCBI's dbSNP database.
aiming-lab/AutoResearchClaw
Runs a metabolic flux analysis from model loading to phenotype prediction and figures by handing work to four sub-agents in sequence.
aipoch/medical-research-skills
Complete workflow for generating academic research posters from PDF literature; use when you need to extract paper content from PDFs and produce a LaTeX-based poster…
aipoch/medical-research-skills
Analyzes clinical diagnostic accuracy studies for bias using the QUADAS-2 tool.
aipoch/medical-research-skills
Perform comprehensive exploratory data analysis on scientific data files across 200+ file formats.
aipoch/medical-research-skills
A toolkit for preparing ISO 13485:2016 certification documentation for medical device QMS.
aipoch/medical-research-skills
Recommends target journals for manuscript submission by analyzing the paper topic/abstract and the journal distribution of similar PubMed literature; use when users ask for journal…
aipoch/medical-research-skills
Creates academic-poster writing packages for LaTeX using beamerposter, tikzposter, or baposter.
Categories
A skill your agent uses when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score…. Ssgsea Immune Infiltration Analysis is an agent skill from aipoch/medical-research-skills. Use when estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA, comparing case versus control groups, and generating downstream immune-score visualizations.
Ssgsea Immune Infiltration Analysis fits situations like: estimating immune infiltration from bulk RNA-seq expression matrices with ssGSEA/GSVA; comparing case versus control groups; generating downstream immune-score visualizations.
Run `npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a claude-code`. Or copy the skill folder (awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis in aipoch/medical-research-skills) into .claude/skills/ssgsea-immune-infiltration-analysis in your project. Claude Code loads it when a task matches its description.
Run `npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a codex`. Or copy the skill folder (awesome-med-research-skills/Data Analysis/ssgsea-immune-infiltration-analysis in aipoch/medical-research-skills) into .agents/skills/ssgsea-immune-infiltration-analysis in your project. Codex loads it when a task matches its description.
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add aipoch/medical-research-skills --skill ssgsea-immune-infiltration-analysis -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/ssgsea-immune-infiltration-analysis, .gemini/skills/ssgsea-immune-infiltration-analysis, .github/skills/ssgsea-immune-infiltration-analysis and .opencode/skills/ssgsea-immune-infiltration-analysis in your project.
Going by SKILL.md and its folder, Ssgsea Immune Infiltration Analysis needs R for the scripts in its folder.
SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. The check reads SKILL.md only: the scripts in the folder are not scanned, so read them before running anything.
Ssgsea Immune Infiltration Analysis is published under the MIT licence (declared in SKILL.md). It allows redistribution, so the full SKILL.md is shown on this page.
About 1.7k tokens (SKILL.md is roughly 7k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full. Its references folder adds about 2.8k tokens, read only when the agent opens those files.
Skills that share tags, products or a category with Ssgsea Immune Infiltration Analysis: Alphagenome Single Variant Analysis (google-deepmind/science-skills, 3.2k stars), 13C Metabolic Flux Analysis (K-Dense-AI/scientific-agent-skills, 48k stars), Clinvar Database (google-deepmind/science-skills, 3.2k stars) and Metabolic Study Planner (aiming-lab/AutoResearchClaw, 15k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
aipoch (a GitHub organization) maintains it in aipoch/medical-research-skills, which has 1,937 GitHub stars. The repository holds 578 skills in this directory. The repository was last updated on September 17, 2026.
Source: aipoch/medical-research-skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.