Agent skill

Tooluniverse Variant Interpretation

Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.

No licenceAuto-check passedWriting & Content

Install Tooluniverse Variant Interpretation

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .claude/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Paste into Claude Code

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .claude/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

$skill-installer

$skill-installer install https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation

Type this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a codex

Project install goes to .agents/skills/; add -g for ~/.codex/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation --agent codex

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .agents/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .agents/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.agents/skills/ instead of .agents/skills for a personal install.

Codex skills documentation · loads skills from .agents/skills/

Paste into Codex

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .agents/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a cursor

Project install goes to .agents/skills/; add -g for ~/.cursor/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation --agent cursor

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .cursor/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.cursor/skills/ instead of .cursor/skills for a personal install.

Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/

Paste into Cursor

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .cursor/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

gemini skills install

$ gemini skills install https://github.com/wu-yc/LabClaw.git --path skills/bio/tooluniverse-variant-interpretation

--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a gemini-cli

Project install goes to .agents/skills/; add -g for ~/.gemini/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation --agent gemini-cli

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .gemini/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.

Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/

Paste into Gemini CLI

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .gemini/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation

Installs for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a github-copilot

Project install goes to .agents/skills/; add -g for ~/.copilot/skills/.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .github/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .github/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.

GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/

Paste into GitHub Copilot

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .github/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a opencode

OpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-variant-interpretation --agent opencode

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/skills/bio/tooluniverse-variant-interpretation .opencode/skills/tooluniverse-variant-interpretation && rm -rf skills-src

Use ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.

OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/

Paste into OpenCode

Install the "tooluniverse-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/bio/tooluniverse-variant-interpretation into .opencode/skills/tooluniverse-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-variant-interpretation", then confirm the skill loads.

OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

Facts

Skill name: tooluniverse-variant-interpretation
GitHub stars: 1.1k
Used in: 2 other repos
Token cost: ~9.5k tokens
SKILL.md length: 1,682 words
Files: 1
Skills in repo: 68
Repo updated: Mar 19, 2026
First seen: Oct 7, 2026
Licence: None found

At a glance

Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.

Works in 8 steps: Variant Identity & Normalization → Clinical Database Queries → 5: Regulatory Context (NEW - for… → …
Interpreting genetic variants
SKILL.md covers Problem This Skill Solves, Key Principles, Triggers and Workflow Overview, plus 4 more sections
Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Tooluniverse Variant Interpretation is an agent skill from wu-yc/LabClaw. Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.

Its SKILL.md is about 9.5k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Writing & Content, covering Translation. It works with UniProt. The repository describes itself as: LabClaw – Operating Layer for LabOS (Stanford-Princeton AI Co-Scientists).

When your agent uses it

Interpreting genetic variants
Classifying variants of uncertain significance (VUS)
Performing ACMG variant classification
Translating variant calls to clinical actionability

Example prompts

“/tooluniverse-variant-interpretation”

Requirements

Python 3

Workflow steps

8 steps, taken from the step headings in SKILL.md.

Variant Identity & Normalization
Clinical Database Queries
5: Regulatory Context (NEW - for Non-Coding Variants)
Computational Predictions (ENHANCED)
Structural Analysis
5: Expression Context (NEW)
Literature Evidence (ENHANCED)
ACMG Classification

What it can do on your machine

Read from SKILL.md and the folder at commit df37802. It shows what the files ask for, not the result of running them.

Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
No scripts in the folder and no shell commands in SKILL.md (its code samples are python and markdown).
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Tooluniverse Variant Interpretation loads about 9.5k tokens when it runs. Until then it costs about 135 tokens; SKILL.md has 1,682 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it: ~135
When it runs · the whole SKILL.md, loaded when a task matches: ~9.5k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 1,682 words (~9,505 tokens).

“name: tooluniverse-variant-interpretation description: Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use…”

— opening of SKILL.md by wu-yc

name: tooluniverse-variant-interpretation

Outline of SKILL.md

Clinical Variant Interpreter
Problem This Skill Solves
Key Principles
Triggers
Workflow Overview
Phase Details
Phase 1: Variant Identity & Normalization
Phase 2: Clinical Database Queries
2.1 COSMIC for Somatic Context (NEW)
2.2 OMIM Gene-Disease Context (NEW)
2.3 DisGeNET Gene-Disease Evidence (NEW)
2.4 ClinGen Gene Validity & Dosage Sensitivity (NEW)
2.5 SpliceAI Splice Variant Prediction (NEW)
Phase 2.5: Regulatory Context (NEW - for Non-Coding Variants)
Phase 3: Computational Predictions (ENHANCED)
3.1 CADD Deleteriousness Scoring (NEW)
3.2 AlphaMissense Pathogenicity (NEW)
3.3 EVE Evolutionary Prediction (NEW)
3.4 Integrated Prediction Strategy
Phase 4: Structural Analysis
Phase 4.5: Expression Context (NEW)
Phase 5: Literature Evidence (ENHANCED)
Phase 6: ACMG Classification
Output Structure
Report Sections
Evidence Grading
Classification Confidence
Structural Impact Confidence
Special Scenarios
Scenario 1: Novel Missense VUS

Read the full SKILL.md on GitHub

Files

Just SKILL.md in skills/bio/tooluniverse-variant-interpretation of wu-yc/LabClaw.

Open the folder on GitHubat commit df37802

Used in 2 other repositories

We found 2 copies of this SKILL.md (exact, near-identical or edited) in other folders, from 2 other GitHub owners. This page covers the copy in wu-yc/LabClaw, which our catalogue first saw on October 7, 2026.

Compare with similar skills

Tooluniverse Variant Interpretation next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Tooluniverse Variant Interpretation compared with similar skills
Skill	Stars	Used in	Tokens	Auto-check	Licence	Repo updated
Tooluniverse Variant Interpretation this skillwu-yc/LabClaw	1.1k	2 repos	~9.5k	Automated safety check: Pass	None	6 mo ago
Translation Diff ExportDevolutions/UniGetUI	26k	—	~1.1k	Automated safety check: Pass	MIT	yesterday
Sync Translationssymfony/symfony	31k	—	~1.9k	Automated safety check: Pass	MIT	today
Translation Diff ImportDevolutions/UniGetUI	26k	—	~750	Automated safety check: Pass	MIT	yesterday
Translation Diff TranslateDevolutions/UniGetUI	26k	—	~934	Automated safety check: Pass	MIT	yesterday
Generate Translationspayloadcms/payload	45k	—	~1.1k	Automated safety check: Pass	MIT	yesterday

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Works with

UniProt

Questions about Tooluniverse Variant Interpretation

What does Tooluniverse Variant Interpretation do?

Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Tooluniverse Variant Interpretation is an agent skill from wu-yc/LabClaw. Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis.

When should I use Tooluniverse Variant Interpretation?

Tooluniverse Variant Interpretation fits situations like: interpreting genetic variants; classifying variants of uncertain significance (VUS); performing ACMG variant classification; translating variant calls to clinical actionability.

How do I install Tooluniverse Variant Interpretation in Claude Code?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a claude-code`. Or copy the skill folder (skills/bio/tooluniverse-variant-interpretation in wu-yc/LabClaw) into .claude/skills/tooluniverse-variant-interpretation in your project. Claude Code loads it when a task matches its description.

How do I install Tooluniverse Variant Interpretation in Codex?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a codex`. Or copy the skill folder (skills/bio/tooluniverse-variant-interpretation in wu-yc/LabClaw) into .agents/skills/tooluniverse-variant-interpretation in your project. Codex loads it when a task matches its description.

Can I use Tooluniverse Variant Interpretation in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add wu-yc/LabClaw --skill tooluniverse-variant-interpretation -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/tooluniverse-variant-interpretation, .gemini/skills/tooluniverse-variant-interpretation, .github/skills/tooluniverse-variant-interpretation and .opencode/skills/tooluniverse-variant-interpretation in your project.

What does Tooluniverse Variant Interpretation need to run?

SKILL.md names no scripts, command-line tools or credentials: Tooluniverse Variant Interpretation is instructions for the agent only. Our summary lists: Python 3.

Does Tooluniverse Variant Interpretation access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Tooluniverse Variant Interpretation safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Tooluniverse Variant Interpretation use?

No licence was found for Tooluniverse Variant Interpretation or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Tooluniverse Variant Interpretation use?

About 9.5k tokens (SKILL.md is roughly 38k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Tooluniverse Variant Interpretation?

Skills that share tags, products or a category with Tooluniverse Variant Interpretation: Translation Diff Export (Devolutions/UniGetUI, 26k stars), Sync Translations (symfony/symfony, 31k stars), Translation Diff Import (Devolutions/UniGetUI, 26k stars) and Translation Diff Translate (Devolutions/UniGetUI, 26k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Tooluniverse Variant Interpretation?

wu-yc (a GitHub user) maintains it in wu-yc/LabClaw, which has 1,055 GitHub stars. The repository holds 68 skills in this directory. The repository was last updated on March 19, 2026.

Source: wu-yc/LabClaw on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.

Install Tooluniverse Variant Interpretation

Facts

At a glance

What it does

When your agent uses it

Example prompts

Requirements

Workflow steps

What it can do on your machine

Tool permissions

Runs code

Network

Credentials

Context cost

Safety

SKILL.md

Files

Used in 2 other repositories

Compare with similar skills

Similar skills

More from wu-yc/LabClaw

Related

Questions about Tooluniverse Variant Interpretation