Agent skill

Tooluniverse Cancer Variant Interpretation

Provide comprehensive clinical interpretation of somatic mutations in cancer.

No licenceAuto-check passedResearch & Science

Install Tooluniverse Cancer Variant Interpretation

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .claude/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Paste into Claude Code

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .claude/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

$skill-installer

$skill-installer install https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation

Type this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a codex

Project install goes to .agents/skills/; add -g for ~/.codex/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation --agent codex

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .agents/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .agents/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.agents/skills/ instead of .agents/skills for a personal install.

Codex skills documentation · loads skills from .agents/skills/

Paste into Codex

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .agents/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a cursor

Project install goes to .agents/skills/; add -g for ~/.cursor/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation --agent cursor

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .cursor/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.cursor/skills/ instead of .cursor/skills for a personal install.

Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/

Paste into Cursor

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .cursor/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

gemini skills install

$ gemini skills install https://github.com/wu-yc/LabClaw.git --path skills/med/tooluniverse-cancer-variant-interpretation

--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a gemini-cli

Project install goes to .agents/skills/; add -g for ~/.gemini/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation --agent gemini-cli

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .gemini/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.

Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/

Paste into Gemini CLI

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .gemini/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation

Installs for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a github-copilot

Project install goes to .agents/skills/; add -g for ~/.copilot/skills/.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .github/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .github/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.

GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/

Paste into GitHub Copilot

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .github/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

skills CLI

$ npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a opencode

OpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.

GitHub CLI

$ gh skill install wu-yc/LabClaw tooluniverse-cancer-variant-interpretation --agent opencode

Project scope by default (.agents/skills/); add --scope user for a personal install.

Manual copy

$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/skills/med/tooluniverse-cancer-variant-interpretation .opencode/skills/tooluniverse-cancer-variant-interpretation && rm -rf skills-src

Use ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.

OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/

Paste into OpenCode

Install the "tooluniverse-cancer-variant-interpretation" agent skill from https://github.com/wu-yc/LabClaw/tree/main/skills/med/tooluniverse-cancer-variant-interpretation into .opencode/skills/tooluniverse-cancer-variant-interpretation/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "tooluniverse-cancer-variant-interpretation", then confirm the skill loads.

OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.

Facts

Skill name: tooluniverse-cancer-variant-interpretation
GitHub stars: 1.1k
Used in: 2 other repos
Token cost: ~8.9k tokens
SKILL.md length: 1,721 words
Files: 1
Skills in repo: 68
Repo updated: Mar 19, 2026
First seen: Oct 7, 2026
Licence: None found

At a glance

Provide comprehensive clinical interpretation of somatic mutations in cancer.

Works in 9 steps: Tool Parameter Verification (CRITICAL) → Gene Disambiguation & ID Resolution → Clinical Variant Evidence (CIViC) → …
Molecular tumor boards
SKILL.md covers When to Use, Input Parsing, Phase 0: Tool Parameter… and Workflow Overview, plus 4 more sections
Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Tooluniverse Cancer Variant Interpretation is an agent skill from wu-yc/LabClaw. Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when…

Its SKILL.md is about 8.9k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science, covering Clinical and healthcare research. The repository describes itself as: LabClaw – Operating Layer for LabOS (Stanford-Princeton AI Co-Scientists).

When your agent uses it

Molecular tumor boards
Researchers ask about treatment options for specific cancer mutations
Resistance mechanisms
Clinical trial matching

Example prompts

“/tooluniverse-cancer-variant-interpretation”

Requirements

Python 3

Workflow steps

9 steps, taken from the step headings in SKILL.md.

Tool Parameter Verification (CRITICAL)
Gene Disambiguation & ID Resolution
Clinical Variant Evidence (CIViC)
Mutation Prevalence (cBioPortal)
Therapeutic Associations
Resistance Mechanisms
Clinical Trials
Prognostic Impact & Pathway Context
Report Synthesis

What it can do on your machine

Read from SKILL.md and the folder at commit df37802. It shows what the files ask for, not the result of running them.

Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
No scripts in the folder and no shell commands in SKILL.md (its code samples are python and markdown).
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Tooluniverse Cancer Variant Interpretation loads about 8.9k tokens when it runs. Until then it costs about 179 tokens; SKILL.md has 1,721 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it: ~179
When it runs · the whole SKILL.md, loaded when a task matches: ~8.9k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 1,721 words (~8,902 tokens).

“Comprehensive clinical interpretation of somatic mutations in cancer. Transforms a gene + variant input into an actionable precision oncology report covering clinical evidence, therapeutic options, resistance mechanisms, clinical trials, and prognostic implications.”

— opening of SKILL.md by wu-yc

name: tooluniverse-cancer-variant-interpretation

Outline of SKILL.md

Cancer Variant Interpretation for Precision Oncology
When to Use
Input Parsing
Accepted Input Formats
Gene Symbol Normalization
Phase 0: Tool Parameter Verification (CRITICAL)
Known Parameter Corrections
Workflow Overview
Phase 1: Gene Disambiguation & ID Resolution
1.1 MyGene ID Resolution (PRIMARY)
1.2 UniProt Accession
1.3 OpenTargets Target Resolution
1.4 Cancer Type EFO Resolution (if cancer type provided)
1.5 Gene Function Context
1.6 CIViC Gene ID Resolution
Phase 2: Clinical Variant Evidence (CIViC)
2.1 Get Gene Variants from CIViC
2.2 Match Specific Variant
2.3 Get Variant Details
2.4 Get Molecular Profile Evidence
2.5 CIViC Evidence Limitations and Fallback
Evidence Level Mapping
Phase 3: Mutation Prevalence (cBioPortal)
3.1 Find Relevant Studies
3.2 Get Mutation Data
3.3 Analyze Mutation Distribution
3.4 Key cBioPortal Studies for Common Cancer Types
Phase 4: Therapeutic Associations
4.1 OpenTargets Drug-Target Associations (PRIMARY)
4.2 OpenTargets Drug Mechanisms

Read the full SKILL.md on GitHub

Files

Just SKILL.md in skills/med/tooluniverse-cancer-variant-interpretation of wu-yc/LabClaw.

Open the folder on GitHubat commit df37802

Used in 2 other repositories

We found 2 copies of this SKILL.md (exact, near-identical or edited) in other folders, from 2 other GitHub owners. This page covers the copy in wu-yc/LabClaw, which our catalogue first saw on October 7, 2026.

Compare with similar skills

Tooluniverse Cancer Variant Interpretation next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Tooluniverse Cancer Variant Interpretation compared with similar skills
Skill	Stars	Used in	Tokens	Auto-check	Licence	Repo updated
Tooluniverse Cancer Variant Interpretation this skillwu-yc/LabClaw	1.1k	2 repos	~8.9k	Automated safety check: Pass	None	6 mo ago
Clinical Trials Databasegoogle-deepmind/science-skills	3.2k	2 repos	~3.2k	Automated safety check: Pass	Apache-2.0	yesterday
CHARLS Paper Reproduction Guidexjtulyc/MedgeClaw	617	1 repos	~1.8k	Automated safety check: Pass	None	7 mo ago
Biomedical Analysis Dispatchxjtulyc/MedgeClaw	617	1 repos	~2k	Automated safety check: Pass	None	7 mo ago
Research Paperluwill/research-skills	862	—	~1.9k	Automated safety check: Pass	None	yesterday
Research Proposalluwill/research-skills	862	—	~4.5k	Automated safety check: Notes	None	yesterday

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Questions about Tooluniverse Cancer Variant Interpretation

What does Tooluniverse Cancer Variant Interpretation do?

Provide comprehensive clinical interpretation of somatic mutations in cancer. Tooluniverse Cancer Variant Interpretation is an agent skill from wu-yc/LabClaw. Provide comprehensive clinical interpretation of somatic mutations in cancer.

When should I use Tooluniverse Cancer Variant Interpretation?

Tooluniverse Cancer Variant Interpretation fits situations like: molecular tumor boards; researchers ask about treatment options for specific cancer mutations; resistance mechanisms; clinical trial matching.

How do I install Tooluniverse Cancer Variant Interpretation in Claude Code?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a claude-code`. Or copy the skill folder (skills/med/tooluniverse-cancer-variant-interpretation in wu-yc/LabClaw) into .claude/skills/tooluniverse-cancer-variant-interpretation in your project. Claude Code loads it when a task matches its description.

How do I install Tooluniverse Cancer Variant Interpretation in Codex?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a codex`. Or copy the skill folder (skills/med/tooluniverse-cancer-variant-interpretation in wu-yc/LabClaw) into .agents/skills/tooluniverse-cancer-variant-interpretation in your project. Codex loads it when a task matches its description.

Can I use Tooluniverse Cancer Variant Interpretation in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add wu-yc/LabClaw --skill tooluniverse-cancer-variant-interpretation -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/tooluniverse-cancer-variant-interpretation, .gemini/skills/tooluniverse-cancer-variant-interpretation, .github/skills/tooluniverse-cancer-variant-interpretation and .opencode/skills/tooluniverse-cancer-variant-interpretation in your project.

What does Tooluniverse Cancer Variant Interpretation need to run?

SKILL.md names no scripts, command-line tools or credentials: Tooluniverse Cancer Variant Interpretation is instructions for the agent only. Our summary lists: Python 3.

Does Tooluniverse Cancer Variant Interpretation access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Tooluniverse Cancer Variant Interpretation safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Tooluniverse Cancer Variant Interpretation use?

No licence was found for Tooluniverse Cancer Variant Interpretation or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Tooluniverse Cancer Variant Interpretation use?

About 8.9k tokens (SKILL.md is roughly 36k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Tooluniverse Cancer Variant Interpretation?

Skills that share tags, products or a category with Tooluniverse Cancer Variant Interpretation: Clinical Trials Database (google-deepmind/science-skills, 3.2k stars), CHARLS Paper Reproduction Guide (xjtulyc/MedgeClaw, 617 stars), Biomedical Analysis Dispatch (xjtulyc/MedgeClaw, 617 stars) and Research Paper (luwill/research-skills, 862 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Tooluniverse Cancer Variant Interpretation?

wu-yc (a GitHub user) maintains it in wu-yc/LabClaw, which has 1,055 GitHub stars. The repository holds 68 skills in this directory. The repository was last updated on March 19, 2026.

Source: wu-yc/LabClaw on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.

Install Tooluniverse Cancer Variant Interpretation

Facts

At a glance

What it does

When your agent uses it

Example prompts

Requirements

Workflow steps

What it can do on your machine

Tool permissions

Runs code

Network

Credentials

Context cost

Safety

SKILL.md

Files

Used in 2 other repositories

Compare with similar skills

Similar skills

More from wu-yc/LabClaw

Related

Questions about Tooluniverse Cancer Variant Interpretation