Alphafold Database Fetch And Analyze
google-deepmind/science-skills
Retrieve and analyze AlphaFold predicted structures for a protein.
This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry.
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install K-Dense-AI/mimeo demis-hassabis --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .claude/skills && cp -r skills-src/output/demis-hassabis .claude/skills/demis-hassabis && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .claude/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabisType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install K-Dense-AI/mimeo demis-hassabis --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .agents/skills && cp -r skills-src/output/demis-hassabis .agents/skills/demis-hassabis && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .agents/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install K-Dense-AI/mimeo demis-hassabis --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/output/demis-hassabis .cursor/skills/demis-hassabis && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .cursor/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/K-Dense-AI/mimeo.git --path output/demis-hassabis--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install K-Dense-AI/mimeo demis-hassabis --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/output/demis-hassabis .gemini/skills/demis-hassabis && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .gemini/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install K-Dense-AI/mimeo demis-hassabisInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .github/skills && cp -r skills-src/output/demis-hassabis .github/skills/demis-hassabis && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .github/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install K-Dense-AI/mimeo demis-hassabis --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/K-Dense-AI/mimeo.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/output/demis-hassabis .opencode/skills/demis-hassabis && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "demis-hassabis" agent skill from https://github.com/K-Dense-AI/mimeo/tree/main/output/demis-hassabis into .opencode/skills/demis-hassabis/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "demis-hassabis", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
demis-hassabisThis skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry.
Demis Hassabis is an agent skill from K-Dense-AI/mimeo. This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry. Use this skill whenever you are evaluating AI for scientific discovery, tackling "root node" problems, designing reinforcement learning systems, or discussing AGI timelines, safety, and global governance. Reach for it when the user faces massive combinatorial search spaces, wants to apply AI to physical/biological sciences (like digital…
Its SKILL.md is about 2k tokens, which your agent loads only when the skill is triggered. The skill folder holds 10 other files, including reference files (for example `AGENTS.md`, `references/anti-patterns.md` and `references/frameworks.md`).
It sits in AI & LLM Engineering, covering Reinforcement learning and Protein structure and design. It works with AlphaFold. The repository describes itself as: Mimeograph an expert into a SKILL.md or AGENTS.md for your agent. The licence is MIT.
3 steps, taken from the first numbered list in SKILL.md.
Read from SKILL.md and the folder at commit a4cea18. It shows what the files ask for, not the result of running them.
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
No scripts in the folder and no shell commands in SKILL.md.
From the folder's file list and the shell code blocks in SKILL.md.
Links to these hosts (documentation or services it may open):
arxiv.orgFrom URLs in SKILL.md, links to its own repository left out.
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Demis Hassabis loads about 2k tokens when it runs, and up to ~8.3k if it reads all its reference files. Until then it costs about 189 tokens; SKILL.md has 993 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
The full file from K-Dense-AI/mimeo at commit a4cea18, republished under its MIT licence (© K-Dense-AI). 993 words, ~1,973 tokens.
.claude/skills/demis-hassabis/SKILL.md (or your agent's skills folder). This skill also uses 9 other files; get the full folder from GitHub.Demis Hassabis views artificial intelligence not merely as a product or a chatbot, but as the ultimate meta-solution for scientific discovery. His thinking is defined by a deep synthesis of neuroscience, computer science, and physics. He approaches AI as an "engineering science" where artifacts must be built before they can be deconstructed and understood, and he consistently targets "root node" problems—foundational challenges like protein folding or nuclear fusion that, once solved, unlock entire branches of human knowledge.
Reach for this skill whenever you're evaluating AI's role in scientific discovery, designing systems to navigate massive combinatorial search spaces, discussing the trajectory and safety of AGI, or looking to apply the rigorous scientific method to machine learning development.
For detailed rationale and quotes, see references/principles.md.
Hassabis reasons from first principles, viewing the universe fundamentally through the lens of information. When faced with a problem, he first asks if it can be framed as a massive combinatorial search space with a clear objective function. He emphasizes building "World Models" (intuitive physics) and leveraging "Deep Reinforcement Learning" to guide search efficiently. He actively dismisses the traditional Silicon Valley "move fast and break things" ethos, preferring a CERN-like, rigorous scientific approach to AI development.
He conceptualizes biology as a complex information processing system ("Digital Biology") and views current AI systems as possessing a "Capability Overhang"—latent power waiting to be unlocked. For a deeper dive into these lenses, see references/mental-models.md.
When to use: To evaluate if a real-world or scientific challenge is ripe for a modern AI solution.
When to use: To make massive combinatorial search spaces tractable.
When to use: To push an AI system to superhuman, generalized capabilities by removing human bias.
For the full catalog of frameworks, see references/frameworks.md.
For the full catalog with rationale and quotes, see references/anti-patterns.md.
For the full list with attribution, see references/heuristics.md.
When the user is discussing AI strategy, scientific discovery, or AGI timelines, channel Hassabis's rigorous, science-first mindset. Surface relevant frameworks by name (e.g., "Demis Hassabis suggests evaluating this using his Criteria for a Suitable AI Problem"). If the user is trying to solve a complex biological or physical problem, introduce the concept of "Digital Biology" or "Model-Guided Search."
Push back against reckless scaling or "move fast and break things" mentalities by citing the "Precautionary Principle for AGI." Always frame AI as a tool (a microscope or telescope) for understanding reality, rather than just a commercial product. Do not pretend to be Demis Hassabis; instead, apply his mental models to the user's specific context to elevate their strategic and scientific reasoning.
Generated with mimeo. If this material contributes to published work, please cite Kassis, T. (2026). "mimeo: Compiling Public Expert Corpora into Agent Skills and Testing What Transfers." arXiv:2609.00453.
© K-Dense-AI, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file
SKILL.md and 9 other files (references) in output/demis-hassabis of K-Dense-AI/mimeo.
Open the folder on GitHubat commit a4cea18
We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders. This page covers the copy in K-Dense-AI/mimeo, which our catalogue first saw on October 7, 2026.
Demis Hassabis next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Demis Hassabis this skillK-Dense-AI/mimeo | 282 | — | ~2k | Automated safety check: Pass | MIT | |
| Alphafold Database Fetch And Analyzegoogle-deepmind/science-skills | 3.2k | 2 repos | ~1.2k | Automated safety check: Pass | Apache-2.0 | |
| Esmfold2JimLiu/science-skills | 228 | 4 repos | ~2.5k | Automated safety check: Pass | Apache-2.0 | |
| Alphafoldadaptyvbio/protein-design-skills | 164 | 3 repos | ~1.2k | Automated safety check: Pass | MIT | |
| Biopipelineslocbp-uzh/biopipelines | 109 | — | ~2.4k | Automated safety check: Pass | MIT | |
| Chaiadaptyvbio/protein-design-skills | 164 | 3 repos | ~1.5k | Automated safety check: Pass | MIT |
google-deepmind/science-skills
Retrieve and analyze AlphaFold predicted structures for a protein.
JimLiu/science-skills
Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al.
adaptyvbio/protein-design-skills
Validate protein designs using AlphaFold2 structure prediction.
locbp-uzh/biopipelines
Design and run computational protein and ligand workflows on a GPU: binder and enzyme design, de novo backbone generation, inverse folding and sequence redesign, structure prediction, protein-ligand…
adaptyvbio/protein-design-skills
Structure prediction using Chai-1, a foundation model for molecular structure.
DrugClaw/DrugClaw
Query public biology databases and APIs including UniProt, RCSB PDB, AlphaFold DB, ClinVar, dbSNP, gnomAD, Ensembl, GEO, InterPro, KEGG, OpenTargets, Reactome, and STRING.
K-Dense-AI/mimeo
Applies the mental models and frameworks of Andrej Karpathy (deep learning, former Director of AI at Tesla, founding member of OpenAI, Eureka Labs).
K-Dense-AI/mimeo
Applies the reasoning, principles, and frameworks of Andrew Ng (machine learning pioneer, co-founder of Coursera and DeepLearning.AI, Stanford University, and former Google Brain lead).
K-Dense-AI/mimeo
Applies the reasoning, architectural principles, and AI philosophy of Christopher Manning (natural language processing expert, Stanford University, director of Stanford AI Lab).
K-Dense-AI/mimeo
Applies the reasoning style of Daphne Koller (machine learning pioneer, co-founder of Coursera, founder and CEO of Insitro).
K-Dense-AI/mimeo
Applies the reasoning, frameworks, and mental models of Fei-Fei Li, computer vision pioneer, ImageNet creator, and co-director of Stanford HAI.
K-Dense-AI/mimeo
Applies the reasoning style of Geoffrey Hinton, deep learning pioneer and 2018 Turing Award winner.
Works with
Categories
This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry. Demis Hassabis is an agent skill from K-Dense-AI/mimeo. This skill channels the strategic and scientific reasoning of Demis Hassabis, CEO and co-founder of Google DeepMind, AlphaGo and AlphaFold, and 2024 Nobel Prize in Chemistry.
Demis Hassabis fits situations like: you are evaluating AI for scientific discovery; tackling root node problems; designing reinforcement learning systems; discussing AGI timelines.
Run `npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a claude-code`. Or copy the skill folder (output/demis-hassabis in K-Dense-AI/mimeo) into .claude/skills/demis-hassabis in your project. Claude Code loads it when a task matches its description.
Run `npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a codex`. Or copy the skill folder (output/demis-hassabis in K-Dense-AI/mimeo) into .agents/skills/demis-hassabis in your project. Codex loads it when a task matches its description.
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add K-Dense-AI/mimeo --skill demis-hassabis -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/demis-hassabis, .gemini/skills/demis-hassabis, .github/skills/demis-hassabis and .opencode/skills/demis-hassabis in your project.
SKILL.md names no scripts, command-line tools or credentials: Demis Hassabis is instructions for the agent only.
SKILL.md names 1 domain. As links in the text: arxiv.org. This is read from the text; nothing was executed.
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
Demis Hassabis is published under the MIT licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.
About 2k tokens (SKILL.md is roughly 7.9k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full. Its references folder adds about 6.3k tokens, read only when the agent opens those files.
Skills that share tags, products or a category with Demis Hassabis: Alphafold Database Fetch And Analyze (google-deepmind/science-skills, 3.2k stars), Esmfold2 (JimLiu/science-skills, 228 stars), Alphafold (adaptyvbio/protein-design-skills, 164 stars) and Biopipelines (locbp-uzh/biopipelines, 109 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
K-Dense-AI (a GitHub organization) maintains it in K-Dense-AI/mimeo, which has 282 GitHub stars. The repository holds 21 skills in this directory. The repository was last updated on September 2, 2026.
Source: K-Dense-AI/mimeo on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.