Agent skill

Bio Variant Calling Deepvariant

by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills

Deep learning-based variant calling with Google DeepVariant.

No licenceAuto-check passedResearch & Science

Install Bio Variant Calling Deepvariant

skills CLI
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-variant-calling-deepvariant -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-variant-calling-deepvariant --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-variant-calling-deepvariant .claude/skills/bio-variant-calling-deepvariant && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bio-variant-calling-deepvariant
GitHub stars
3.1k
Used in
1 other repo
Token cost
~2.3k tokens
SKILL.md length
503 words
Files
3
Skills in repo
279
Repo updated
First seen
Licence
None found

At a glance

Deep learning-based variant calling with Google DeepVariant.

  • Works in 3 steps: Make Examples → Call Variants → Postprocess Variants
  • Calling variants with DeepVariant deep learning caller
  • SKILL.md covers Version Compatibility, Installation, Basic Usage and Step-by-Step Workflow, plus 12 more sections
  • Runs Shell scripts from its folder; calls docker

What it does

Bio Variant Calling Deepvariant is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Deep learning-based variant calling with Google DeepVariant. Provides high accuracy for germline SNPs and indels from Illumina, PacBio, and ONT data. Use when calling variants with DeepVariant deep learning caller.

Its SKILL.md is about 2.3k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/run_deepvariant.sh` and `usage-guide.md`).

It sits in Research & Science, covering Bioinformatics and Deep learning. It works with Docker. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.

When your agent uses it

  • Calling variants with DeepVariant deep learning caller
  • Tasks that involve Bioinformatics
  • Tasks that involve Deep learning

Example prompts

  • “/bio-variant-calling-deepvariant”

Requirements

  • A Bash shell
  • Docker

Workflow steps

3 steps, taken from the step headings in SKILL.md.

  1. Make Examples
  2. Call Variants
  3. Postprocess Variants

What it can do on your machine

Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Ships script files (Shell), which the agent can run.

    Shell commands in SKILL.md call:

    • docker

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md. Its commands use docker, which can reach the network depending on how they are called.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bio Variant Calling Deepvariant loads about 2.3k tokens when it runs. Until then it costs about 62 tokens; SKILL.md has 503 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~62
When it runs · the whole SKILL.md, loaded when a task matches
~2.3k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 503 words (~2,283 tokens).

“Reference examples tested with: GATK 4.5+, bcftools 1.19+”

— opening of SKILL.md by FreedomIntelligence
name
bio-variant-calling-deepvariant
tool_type
cli
primary_tool
DeepVariant

Read the full SKILL.md on GitHub

Files

SKILL.md and 2 other files in skills/bio-variant-calling-deepvariant of FreedomIntelligence/OpenClaw-Medical-Skills.

  • SKILL.md
  • examples/run_deepvariant.sh
  • usage-guide.md

Open the folder on GitHubat commit b1f9b6e

Used in 1 other repository

We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders, from 1 other GitHub owner. This page covers the copy in FreedomIntelligence/OpenClaw-Medical-Skills, which our catalogue first saw on October 7, 2026.

Compare with similar skills

Bio Variant Calling Deepvariant next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Bio Variant Calling Deepvariant compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Bio Variant Calling Deepvariant this skillFreedomIntelligence/OpenClaw-Medical-Skills3.1k1 repos~2.3kAutomated safety check: PassNone
tangermeme Genomic Model Analysisjmschrei/tangermeme316—~1.6kAutomated safety check: PassMIT
Cellxgene Censusdavila7/claude-code-templates32k11 repos~3.8kAutomated safety check: PassMIT
Pixi Environment Builderxuzhougeng/wisp-science1k—~3.7kAutomated safety check: PassAGPL-3.0
Bio Long Read Sequencing Clair3 VariantsGPTomics/bioSkills1.2k1 repos~2.9kAutomated safety check: PassMIT
Trackplotygidtu/trackplot109—~1.9kAutomated safety check: PassBSD-3-Clause

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Works with

Questions about Bio Variant Calling Deepvariant

What does Bio Variant Calling Deepvariant do?

Deep learning-based variant calling with Google DeepVariant. Bio Variant Calling Deepvariant is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Deep learning-based variant calling with Google DeepVariant.

When should I use Bio Variant Calling Deepvariant?

Bio Variant Calling Deepvariant fits situations like: calling variants with DeepVariant deep learning caller; tasks that involve Bioinformatics; tasks that involve Deep learning.

How do I install Bio Variant Calling Deepvariant in Claude Code?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-variant-calling-deepvariant -a claude-code`. Or copy the skill folder (skills/bio-variant-calling-deepvariant in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-variant-calling-deepvariant in your project. Claude Code loads it when a task matches its description.

How do I install Bio Variant Calling Deepvariant in Codex?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-variant-calling-deepvariant -a codex`. Or copy the skill folder (skills/bio-variant-calling-deepvariant in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-variant-calling-deepvariant in your project. Codex loads it when a task matches its description.

Can I use Bio Variant Calling Deepvariant in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-variant-calling-deepvariant -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-variant-calling-deepvariant, .gemini/skills/bio-variant-calling-deepvariant, .github/skills/bio-variant-calling-deepvariant and .opencode/skills/bio-variant-calling-deepvariant in your project.

What does Bio Variant Calling Deepvariant need to run?

Going by SKILL.md and its folder, Bio Variant Calling Deepvariant needs a shell for the scripts in its folder and the command-line tools its instructions call (docker). Our summary lists: A Bash shell; Docker.

Does Bio Variant Calling Deepvariant access the network?

SKILL.md contains no URLs. Its commands use docker, which can reach the network depending on how they are called. This is read from the text; nothing was executed.

Is Bio Variant Calling Deepvariant safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bio Variant Calling Deepvariant use?

No licence was found for Bio Variant Calling Deepvariant or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Bio Variant Calling Deepvariant use?

About 2.3k tokens (SKILL.md is roughly 9.1k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bio Variant Calling Deepvariant?

Skills that share tags, products or a category with Bio Variant Calling Deepvariant: tangermeme Genomic Model Analysis (jmschrei/tangermeme, 316 stars), Cellxgene Census (davila7/claude-code-templates, 32k stars), Pixi Environment Builder (xuzhougeng/wisp-science, 1k stars) and Bio Long Read Sequencing Clair3 Variants (GPTomics/bioSkills, 1.2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bio Variant Calling Deepvariant?

FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,052 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.

Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.