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Agent skill
Bio Genome Engineering Off Target Prediction
by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills
Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms.
Install Bio Genome Engineering Off Target Prediction
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-prediction --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .claude/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .claude/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-predictionType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-prediction --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .agents/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .agents/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .agents/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-prediction --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .cursor/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .cursor/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git --path skills/bio-genome-engineering-off-target-prediction--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-prediction --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .gemini/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .gemini/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-predictionInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .github/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .github/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .github/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-genome-engineering-off-target-prediction --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/skills/bio-genome-engineering-off-target-prediction .opencode/skills/bio-genome-engineering-off-target-prediction && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "bio-genome-engineering-off-target-prediction" agent skill from https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-genome-engineering-off-target-prediction into .opencode/skills/bio-genome-engineering-off-target-prediction/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "bio-genome-engineering-off-target-prediction", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
Facts
- Skill name
bio-genome-engineering-off-target-prediction- GitHub stars
- 3.1k
- Used in
- 1 other repo
- Token cost
- ~2k tokens
- SKILL.md length
- 200 words
- Files
- 3
- Skills in repo
- 279
- Repo updated
- First seen
- Licence
- None found
At a glance
Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms.
- Evaluating guide RNA specificity
- SKILL.md covers Version Compatibility, Cas-OFFinder (CLI), Cas-OFFinder Input Preparation and Parse Cas-OFFinder Output, plus 4 more sections
- Runs Python scripts from its folder; calls pip
- Selecting guides with minimal off-target risk
What it does
Bio Genome Engineering Off Target Prediction is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms. Identify potential unintended cleavage sites genome-wide and assess guide specificity. Use when evaluating guide RNA specificity or selecting guides with minimal off-target risk.
Its SKILL.md is about 2k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/off_target_analysis.py` and `usage-guide.md`).
It sits in Research & Science, covering Bioinformatics and Physical and earth sciences. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.
When your agent uses it
- Evaluating guide RNA specificity
- Selecting guides with minimal off-target risk
Example prompts
- “/bio-genome-engineering-off-target-prediction”
Requirements
- Python 3
What it can do on your machine
Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.
Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
Ships script files (Python), which the agent can run.
Shell commands in SKILL.md call:
pip
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md. Its commands use pip, which can reach the network depending on how they are called.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Context cost
Bio Genome Engineering Off Target Prediction loads about 2k tokens when it runs. Until then it costs about 76 tokens; SKILL.md has 200 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
Safety
Auto-check passed
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
SKILL.md
Without a licence we can't republish the file, so here is its outline and opening line. It has 200 words (~1,960 tokens).
“Reference examples tested with: pandas 2.2+”
- name
- bio-genome-engineering-off-target-prediction
- tool_type
- cli
- primary_tool
- Cas-OFFinder
Files
SKILL.md and 2 other files in skills/bio-genome-engineering-off-target-prediction of FreedomIntelligence/OpenClaw-Medical-Skills.
- SKILL.md
- examples/off_target_analysis.py
- usage-guide.md
Open the folder on GitHubat commit b1f9b6e
Used in 1 other repository
We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders, from 1 other GitHub owner. This page covers the copy in FreedomIntelligence/OpenClaw-Medical-Skills, which our catalogue first saw on October 7, 2026.
Compare with similar skills
Bio Genome Engineering Off Target Prediction next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Bio Genome Engineering Off Target Prediction this skillFreedomIntelligence/OpenClaw-Medical-Skills | 3.1k | 1 repos | ~2k | Automated safety check: Pass | None | |
| Hugging ScienceK-Dense-AI/scientific-agent-skills | 48k | 1 repos | ~2.9k | Automated safety check: Notes | MIT | |
| Bio Temporal Genomics Periodicity DetectionGPTomics/bioSkills | 1.2k | 1 repos | ~5.3k | Automated safety check: Pass | MIT | |
| Bioconductor CrisprscorebioMate-AI/biomate-bioconductor-kb | 804 | — | ~1.9k | Automated safety check: Pass | Custom licence | |
| Alphagenome Single Variant Analysisgoogle-deepmind/science-skills | 3.2k | 2 repos | ~3k | Automated safety check: Notes | Apache-2.0 | |
| AstropyzLanqing/codex-claude-academic-skills | 4.7k | 13 repos | ~2.9k | Automated safety check: Pass | BSD-3-Clause |
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Bioconductor Crisprscore
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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs).
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Related
Categories
Questions about Bio Genome Engineering Off Target Prediction
What does Bio Genome Engineering Off Target Prediction do?
Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms. Bio Genome Engineering Off Target Prediction is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms.
When should I use Bio Genome Engineering Off Target Prediction?
Bio Genome Engineering Off Target Prediction fits situations like: evaluating guide RNA specificity; selecting guides with minimal off-target risk.
How do I install Bio Genome Engineering Off Target Prediction in Claude Code?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a claude-code`. Or copy the skill folder (skills/bio-genome-engineering-off-target-prediction in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-genome-engineering-off-target-prediction in your project. Claude Code loads it when a task matches its description.
How do I install Bio Genome Engineering Off Target Prediction in Codex?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a codex`. Or copy the skill folder (skills/bio-genome-engineering-off-target-prediction in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-genome-engineering-off-target-prediction in your project. Codex loads it when a task matches its description.
Can I use Bio Genome Engineering Off Target Prediction in Cursor, Gemini CLI or GitHub Copilot?
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-off-target-prediction -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-genome-engineering-off-target-prediction, .gemini/skills/bio-genome-engineering-off-target-prediction, .github/skills/bio-genome-engineering-off-target-prediction and .opencode/skills/bio-genome-engineering-off-target-prediction in your project.
What does Bio Genome Engineering Off Target Prediction need to run?
Going by SKILL.md and its folder, Bio Genome Engineering Off Target Prediction needs Python for the scripts in its folder and the command-line tools its instructions call (pip). Our summary lists: Python 3.
Does Bio Genome Engineering Off Target Prediction access the network?
SKILL.md contains no URLs. Its commands use pip, which can reach the network depending on how they are called. This is read from the text; nothing was executed.
Is Bio Genome Engineering Off Target Prediction safe to install?
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
What licence does Bio Genome Engineering Off Target Prediction use?
No licence was found for Bio Genome Engineering Off Target Prediction or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.
How many tokens does Bio Genome Engineering Off Target Prediction use?
About 2k tokens (SKILL.md is roughly 7.8k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.
What are the alternatives to Bio Genome Engineering Off Target Prediction?
Skills that share tags, products or a category with Bio Genome Engineering Off Target Prediction: Hugging Science (K-Dense-AI/scientific-agent-skills, 48k stars), Bio Temporal Genomics Periodicity Detection (GPTomics/bioSkills, 1.2k stars), Bioconductor Crisprscore (bioMate-AI/biomate-bioconductor-kb, 804 stars) and Alphagenome Single Variant Analysis (google-deepmind/science-skills, 3.2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
Who maintains Bio Genome Engineering Off Target Prediction?
FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,053 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.
Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.