Agent skill

Bio Clinical Databases Variant Prioritization

by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills

Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis.

No licenceAuto-check passedProduct & Project Management

Install Bio Clinical Databases Variant Prioritization

skills CLI
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-variant-prioritization -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-variant-prioritization --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-clinical-databases-variant-prioritization .claude/skills/bio-clinical-databases-variant-prioritization && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bio-clinical-databases-variant-prioritization
GitHub stars
3.1k
Token cost
~2k tokens
SKILL.md length
260 words
Files
3
Skills in repo
279
Repo updated
First seen
Licence
None found

At a glance

Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis.

  • Identifying candidate disease-causing variants from exome
  • SKILL.md covers Version Compatibility, Basic Filtering Pipeline, ACMG-Style Filtering and Multi-Database Prioritization, plus 3 more sections
  • Runs Python scripts from its folder; calls pip
  • Genome sequencing

What it does

Bio Clinical Databases Variant Prioritization is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.

Its SKILL.md is about 2k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/prioritize_variants.py` and `usage-guide.md`).

It sits in Product & Project Management, covering Prioritization frameworks and Bioinformatics. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.

When your agent uses it

  • Identifying candidate disease-causing variants from exome
  • Genome sequencing

Example prompts

  • “/bio-clinical-databases-variant-prioritization”

Requirements

  • Python 3

What it can do on your machine

Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Ships script files (Python), which the agent can run.

    Shell commands in SKILL.md call:

    • pip

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md. Its commands use pip, which can reach the network depending on how they are called.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bio Clinical Databases Variant Prioritization loads about 2k tokens when it runs. Until then it costs about 64 tokens; SKILL.md has 260 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~64
When it runs · the whole SKILL.md, loaded when a task matches
~2k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 260 words (~1,960 tokens).

“Reference examples tested with: pandas 2.2+”

— opening of SKILL.md by FreedomIntelligence
name
bio-clinical-databases-variant-prioritization
tool_type
python
primary_tool
pandas

Read the full SKILL.md on GitHub

Files

SKILL.md and 2 other files in skills/bio-clinical-databases-variant-prioritization of FreedomIntelligence/OpenClaw-Medical-Skills.

  • SKILL.md
  • examples/prioritize_variants.py
  • usage-guide.md

Open the folder on GitHubat commit b1f9b6e

Compare with similar skills

Bio Clinical Databases Variant Prioritization next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Bio Clinical Databases Variant Prioritization compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Bio Clinical Databases Variant Prioritization this skillFreedomIntelligence/OpenClaw-Medical-Skills3.1k—~2kAutomated safety check: PassNone
Bio Causal Genomics Effector Gene PrioritizationGPTomics/bioSkills1.2k2 repos~10kAutomated safety check: PassMIT
Bio Clinical Databases Variant PrioritizationGPTomics/bioSkills1.2k2 repos~6.3kAutomated safety check: PassMIT
Bio Workflows Causal Genomics PipelineGPTomics/bioSkills1.2k2 repos~5.5kAutomated safety check: PassMIT
Bio Causal Genomics Heritability PartitioningGPTomics/bioSkills1.2k2 repos~8.9kAutomated safety check: PassMIT
Regulomedb Databasejaechang-hits/SciAgent-Skills3711 repos~5.3kAutomated safety check: PassCC-BY-4.0

Similar skills

  • Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA…

    1.2k GitHub starsUsed in 2 repos~10k tokens
    Product & Project ManagementAuto-check passed
  • Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser…

    1.2k GitHub starsUsed in 2 repos~6.3k tokens
    Product & Project ManagementAuto-check passed
  • End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization…

    1.2k GitHub starsUsed in 2 repos~5.5k tokens
    Research & ScienceAuto-check passed
  • Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes.

    1.2k GitHub starsUsed in 2 repos~8.9k tokens
    Research & ScienceAuto-check passed
  • Regulomedb Database

    jaechang-hits/SciAgent-Skills

    Query RegulomeDB v2 GET REST API to score variants for regulatory function and retrieve overlapping evidence (TF binding, histone marks, DNase peaks, footprints, motifs, eQTLs, chromatin state).

    371 GitHub starsUsed in 1 repo~5.3k tokens
    Research & ScienceAuto-check passed
  • Generates complete comorbidity-oriented shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction.

    2k GitHub stars~4.5k tokensUpdated 22 days ago
    Data & AnalyticsAuto-check passed

More from FreedomIntelligence/OpenClaw-Medical-Skills

All 279 skills in this repo
  • Single Cell Rna Qc

    FreedomIntelligence/OpenClaw-Medical-Skills

    Performs quality control on single-cell RNA-seq data (.h5ad or .h5 files) using scverse best practices with MAD-based filtering and comprehensive visualizations.

    3.1k GitHub starsUsed in 2 repos~2k tokens
    Auto-check passed
  • Differentiation Schemes

    FreedomIntelligence/OpenClaw-Medical-Skills

    Select and apply numerical differentiation schemes for PDE/ODE discretization.

    3.1k GitHub starsUsed in 1 repo~1.4k tokens
    Auto-check: notes
  • Fhir Developer Skill

    FreedomIntelligence/OpenClaw-Medical-Skills

    FHIR API development guide for building healthcare endpoints.

    3.1k GitHub starsUsed in 1 repo~2.5k tokens
    Auto-check passed
  • Linear Solvers

    FreedomIntelligence/OpenClaw-Medical-Skills

    Select and configure linear solvers for systems Ax=b in dense and sparse problems.

    3.1k GitHub starsUsed in 1 repo~1.5k tokens
    Auto-check: notes
  • Medical Research Toolkit

    FreedomIntelligence/OpenClaw-Medical-Skills

    Query 14+ biomedical databases for drug repurposing, target discovery, clinical trials, and literature research.

    3.1k GitHub starsUsed in 1 repo~2.4k tokens
    Auto-check passed
  • Mesh Generation

    FreedomIntelligence/OpenClaw-Medical-Skills

    Plan and evaluate mesh generation for numerical simulations.

    3.1k GitHub starsUsed in 1 repo~1.1k tokens
    Auto-check: notes

Questions about Bio Clinical Databases Variant Prioritization

What does Bio Clinical Databases Variant Prioritization do?

Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Bio Clinical Databases Variant Prioritization is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis.

When should I use Bio Clinical Databases Variant Prioritization?

Bio Clinical Databases Variant Prioritization fits situations like: identifying candidate disease-causing variants from exome; genome sequencing.

How do I install Bio Clinical Databases Variant Prioritization in Claude Code?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-variant-prioritization -a claude-code`. Or copy the skill folder (skills/bio-clinical-databases-variant-prioritization in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-clinical-databases-variant-prioritization in your project. Claude Code loads it when a task matches its description.

How do I install Bio Clinical Databases Variant Prioritization in Codex?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-variant-prioritization -a codex`. Or copy the skill folder (skills/bio-clinical-databases-variant-prioritization in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-clinical-databases-variant-prioritization in your project. Codex loads it when a task matches its description.

Can I use Bio Clinical Databases Variant Prioritization in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-variant-prioritization -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-clinical-databases-variant-prioritization, .gemini/skills/bio-clinical-databases-variant-prioritization, .github/skills/bio-clinical-databases-variant-prioritization and .opencode/skills/bio-clinical-databases-variant-prioritization in your project.

What does Bio Clinical Databases Variant Prioritization need to run?

Going by SKILL.md and its folder, Bio Clinical Databases Variant Prioritization needs Python for the scripts in its folder and the command-line tools its instructions call (pip). Our summary lists: Python 3.

Does Bio Clinical Databases Variant Prioritization access the network?

SKILL.md contains no URLs. Its commands use pip, which can reach the network depending on how they are called. This is read from the text; nothing was executed.

Is Bio Clinical Databases Variant Prioritization safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bio Clinical Databases Variant Prioritization use?

No licence was found for Bio Clinical Databases Variant Prioritization or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Bio Clinical Databases Variant Prioritization use?

About 2k tokens (SKILL.md is roughly 7.8k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bio Clinical Databases Variant Prioritization?

Skills that share tags, products or a category with Bio Clinical Databases Variant Prioritization: Bio Causal Genomics Effector Gene Prioritization (GPTomics/bioSkills, 1.2k stars), Bio Clinical Databases Variant Prioritization (GPTomics/bioSkills, 1.2k stars), Bio Workflows Causal Genomics Pipeline (GPTomics/bioSkills, 1.2k stars) and Bio Causal Genomics Heritability Partitioning (GPTomics/bioSkills, 1.2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bio Clinical Databases Variant Prioritization?

FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,052 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.

Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.