Agent skill

Bio Clinical Databases Clinvar Lookup

by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills

Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF.

No licenceAuto-check passedBackend & APIs

Install Bio Clinical Databases Clinvar Lookup

skills CLI
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-clinvar-lookup -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-clinical-databases-clinvar-lookup --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-clinical-databases-clinvar-lookup .claude/skills/bio-clinical-databases-clinvar-lookup && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bio-clinical-databases-clinvar-lookup
GitHub stars
3.1k
Token cost
~1.4k tokens
SKILL.md length
307 words
Files
3
Skills in repo
279
Repo updated
First seen
Licence
None found

At a glance

Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF.

  • Determining clinical significance of variants for diagnostic
  • SKILL.md covers Version Compatibility, REST API Queries, Local ClinVar VCF and Clinical Significance Categories, plus 4 more sections
  • Runs Python scripts from its folder; calls wget and pip; reaches eutils.ncbi.nlm.nih.gov and ftp.ncbi.nlm.nih.gov
  • Research purposes

What it does

Bio Clinical Databases Clinvar Lookup is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.

Its SKILL.md is about 1.4k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/clinvar_query.py` and `usage-guide.md`).

It sits in Backend & APIs, covering REST APIs. It works with NCBI. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.

When your agent uses it

  • Determining clinical significance of variants for diagnostic
  • Research purposes

Example prompts

  • “/bio-clinical-databases-clinvar-lookup”

Requirements

  • Python 3

What it can do on your machine

Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Ships script files (Python), which the agent can run.

    Shell commands in SKILL.md call:

    • wget
    • pip

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    Hosts in commands or code, which the agent is likely to contact:

    • eutils.ncbi.nlm.nih.gov
    • ftp.ncbi.nlm.nih.gov

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bio Clinical Databases Clinvar Lookup loads about 1.4k tokens when it runs. Until then it costs about 63 tokens; SKILL.md has 307 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~63
When it runs · the whole SKILL.md, loaded when a task matches
~1.4k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 307 words (~1,429 tokens).

“Reference examples tested with: Entrez Direct 21.0+, bcftools 1.19+”

— opening of SKILL.md by FreedomIntelligence
name
bio-clinical-databases-clinvar-lookup
tool_type
python
primary_tool
requests

Read the full SKILL.md on GitHub

Files

SKILL.md and 2 other files in skills/bio-clinical-databases-clinvar-lookup of FreedomIntelligence/OpenClaw-Medical-Skills.

  • SKILL.md
  • examples/clinvar_query.py
  • usage-guide.md

Open the folder on GitHubat commit b1f9b6e

Compare with similar skills

Bio Clinical Databases Clinvar Lookup next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Bio Clinical Databases Clinvar Lookup compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Bio Clinical Databases Clinvar Lookup this skillFreedomIntelligence/OpenClaw-Medical-Skills3.1k—~1.4kAutomated safety check: PassNone
Bio Ensembl RESTGPTomics/bioSkills1.2k2 repos~3.6kAutomated safety check: PassMIT
Bio Pathway Kegg PathwaysGPTomics/bioSkills1.2k1 repos~5.4kAutomated safety check: PassMIT
Kegg Databasejaechang-hits/SciAgent-Skills3741 repos~4.6kAutomated safety check: PassCustom licence
Ncbi Blast APIwentorai/research-plugins2981 repos~1.6kAutomated safety check: PassMIT
Dbsnp Databasejaechang-hits/SciAgent-Skills3741 repos~7.3kAutomated safety check: PassCC0-1.0

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Works with

Questions about Bio Clinical Databases Clinvar Lookup

What does Bio Clinical Databases Clinvar Lookup do?

Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Bio Clinical Databases Clinvar Lookup is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF.

When should I use Bio Clinical Databases Clinvar Lookup?

Bio Clinical Databases Clinvar Lookup fits situations like: determining clinical significance of variants for diagnostic; research purposes.

How do I install Bio Clinical Databases Clinvar Lookup in Claude Code?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-clinvar-lookup -a claude-code`. Or copy the skill folder (skills/bio-clinical-databases-clinvar-lookup in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-clinical-databases-clinvar-lookup in your project. Claude Code loads it when a task matches its description.

How do I install Bio Clinical Databases Clinvar Lookup in Codex?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-clinvar-lookup -a codex`. Or copy the skill folder (skills/bio-clinical-databases-clinvar-lookup in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-clinical-databases-clinvar-lookup in your project. Codex loads it when a task matches its description.

Can I use Bio Clinical Databases Clinvar Lookup in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-clinvar-lookup -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-clinical-databases-clinvar-lookup, .gemini/skills/bio-clinical-databases-clinvar-lookup, .github/skills/bio-clinical-databases-clinvar-lookup and .opencode/skills/bio-clinical-databases-clinvar-lookup in your project.

What does Bio Clinical Databases Clinvar Lookup need to run?

Going by SKILL.md and its folder, Bio Clinical Databases Clinvar Lookup needs Python for the scripts in its folder and the command-line tools its instructions call (wget and pip). Our summary lists: Python 3.

Does Bio Clinical Databases Clinvar Lookup access the network?

SKILL.md names 2 domains. In commands or code: eutils.ncbi.nlm.nih.gov and ftp.ncbi.nlm.nih.gov; the agent is likely to contact these when it follows the instructions. This is read from the text; nothing was executed.

Is Bio Clinical Databases Clinvar Lookup safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bio Clinical Databases Clinvar Lookup use?

No licence was found for Bio Clinical Databases Clinvar Lookup or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Bio Clinical Databases Clinvar Lookup use?

About 1.4k tokens (SKILL.md is roughly 5.7k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bio Clinical Databases Clinvar Lookup?

Skills that share tags, products or a category with Bio Clinical Databases Clinvar Lookup: Bio Ensembl REST (GPTomics/bioSkills, 1.2k stars), Bio Pathway Kegg Pathways (GPTomics/bioSkills, 1.2k stars), Kegg Database (jaechang-hits/SciAgent-Skills, 374 stars) and Ncbi Blast API (wentorai/research-plugins, 298 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bio Clinical Databases Clinvar Lookup?

FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,053 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.

Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.