Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio.

No licenceAuto-check passedResearch & Science

Install Bio Cfdna Preprocessing

skills CLI
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-cfdna-preprocessing -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-cfdna-preprocessing --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-cfdna-preprocessing .claude/skills/bio-cfdna-preprocessing && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bio-cfdna-preprocessing
GitHub stars
3.1k
Used in
1 other repo
Token cost
~1.6k tokens
SKILL.md length
250 words
Files
3
Skills in repo
170
Repo updated
First seen
Licence
None found

At a glance

Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio.

  • Processing plasma cfDNA sequencing data before downstream analysis
  • SKILL.md covers Version Compatibility, Pre-Analytical Considerations, UMI-Aware Pipeline with fgbio and Python Implementation, plus 3 more sections
  • Runs Python scripts from its folder; calls pip

What it does

Bio Cfdna Preprocessing is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.

Its SKILL.md is about 1.6k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files (for example `examples/preprocess_cfdna.py` and `usage-guide.md`).

It sits in Research & Science. It works with Python. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.

When your agent uses it

  • Processing plasma cfDNA sequencing data before downstream analysis

Example prompts

  • “Use the bio-cfdna-preprocessing skill to preprocess cell-free DNA sequencing data including adapter trimming, alignment optimized for short…”
  • “/bio-cfdna-preprocessing”

Requirements

  • Python 3

What it can do on your machine

Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Ships script files (Python), which the agent can run.

    Shell commands in SKILL.md call:

    • pip

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md. Its commands use pip, which can reach the network depending on how they are called.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bio Cfdna Preprocessing loads about 1.6k tokens when it runs. Until then it costs about 83 tokens; SKILL.md has 250 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~83
When it runs · the whole SKILL.md, loaded when a task matches
~1.6k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 250 words (~1,604 tokens).

“Reference examples tested with: BWA 0.7.17+, fgbio 2.1+, matplotlib 3.8+, numpy 1.26+, pysam 0.22+, samtools 1.19+”

— opening of SKILL.md by FreedomIntelligence
name
bio-cfdna-preprocessing
tool_type
python
primary_tool
fgbio

Read the full SKILL.md on GitHub

Files

SKILL.md and 2 other files in skills/bio-cfdna-preprocessing of FreedomIntelligence/OpenClaw-Medical-Skills.

  • SKILL.md
  • examples/preprocess_cfdna.py
  • usage-guide.md

Open the folder on GitHubat commit b1f9b6e

Used in 1 other repository

We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders, from 1 other GitHub owner. This page covers the copy in FreedomIntelligence/OpenClaw-Medical-Skills, which our catalogue first saw on October 7, 2026.

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Works with

Questions about Bio Cfdna Preprocessing

What does Bio Cfdna Preprocessing do?

Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Bio Cfdna Preprocessing is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio.

When should I use Bio Cfdna Preprocessing?

Bio Cfdna Preprocessing fits situations like: processing plasma cfDNA sequencing data before downstream analysis.

How do I install Bio Cfdna Preprocessing in Claude Code?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-cfdna-preprocessing -a claude-code`. Or copy the skill folder (skills/bio-cfdna-preprocessing in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-cfdna-preprocessing in your project. Claude Code loads it when a task matches its description.

How do I install Bio Cfdna Preprocessing in Codex?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-cfdna-preprocessing -a codex`. Or copy the skill folder (skills/bio-cfdna-preprocessing in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-cfdna-preprocessing in your project. Codex loads it when a task matches its description.

Can I use Bio Cfdna Preprocessing in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-cfdna-preprocessing -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-cfdna-preprocessing, .gemini/skills/bio-cfdna-preprocessing, .github/skills/bio-cfdna-preprocessing and .opencode/skills/bio-cfdna-preprocessing in your project.

What does Bio Cfdna Preprocessing need to run?

Going by SKILL.md and its folder, Bio Cfdna Preprocessing needs Python for the scripts in its folder and the command-line tools its instructions call (pip). Our summary lists: Python 3.

Does Bio Cfdna Preprocessing access the network?

SKILL.md contains no URLs. Its commands use pip, which can reach the network depending on how they are called. This is read from the text; nothing was executed.

Is Bio Cfdna Preprocessing safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bio Cfdna Preprocessing use?

No licence was found for Bio Cfdna Preprocessing or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Bio Cfdna Preprocessing use?

About 1.6k tokens (SKILL.md is roughly 6.4k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bio Cfdna Preprocessing?

Skills that share tags, products or a category with Bio Cfdna Preprocessing: GitHub Deep Research (bytedance/deer-flow, 83k stars), Last30days (mvanhorn/last30days-skill, 64k stars), Networkx (zLanqing/codex-claude-academic-skills, 4.6k stars) and Nature-Style Scientific Figures (Yuan1z0825/nature-skills, 46k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bio Cfdna Preprocessing?

FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,052 GitHub stars. The repository holds 170 skills in this directory. The repository was last updated on July 21, 2026.

Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.