Agent skill

Bio Causal Genomics Mendelian Randomization

by FreedomIntelligence in FreedomIntelligence/OpenClaw-Medical-Skills

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR.

No licenceAuto-check passedResearch & Science

Install Bio Causal Genomics Mendelian Randomization

skills CLI
$ npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-causal-genomics-mendelian-randomization -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install FreedomIntelligence/OpenClaw-Medical-Skills bio-causal-genomics-mendelian-randomization --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio-causal-genomics-mendelian-randomization .claude/skills/bio-causal-genomics-mendelian-randomization && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bio-causal-genomics-mendelian-randomization
GitHub stars
3.1k
Token cost
~2.2k tokens
SKILL.md length
450 words
Files
4
Skills in repo
279
Repo updated
First seen
Licence
None found

At a glance

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR.

  • Works in 3 steps: Relevance - The variant is associated… → Independence - The variant is not… → Exclusion restriction - The variant…
  • Testing whether an exposure causally affects an outcome using genetic instruments
  • SKILL.md covers Version Compatibility, Core Concepts, TwoSampleMR Workflow and OpenGWAS Authentication, plus 6 more sections
  • Runs R scripts from its folder; reaches shiny.cnsgenomics.com

What it does

Bio Causal Genomics Mendelian Randomization is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.

Its SKILL.md is about 2.2k tokens, which your agent loads only when the skill is triggered. The skill folder holds 4 other files (for example `usage-guide.md`).

It sits in Research & Science, covering Econometrics and empirical research, Data analysis and Bioinformatics. The repository describes itself as: The largest open-source medical AI skills library for OpenClaw🦞.

When your agent uses it

  • Testing whether an exposure causally affects an outcome using genetic instruments
  • Tasks that involve Econometrics and empirical research
  • Tasks that involve Data analysis

Example prompts

  • “/bio-causal-genomics-mendelian-randomization”

Workflow steps

3 steps, taken from the first numbered list in SKILL.md.

  1. Relevance - The variant is associated with the exposure (F-statistic > 10)
  2. Independence - The variant is not associated with confounders
  3. Exclusion restriction - The variant affects the outcome only through the exposure

What it can do on your machine

Read from SKILL.md and the folder at commit b1f9b6e. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Ships script files (R), which the agent can run.

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    Hosts in commands or code, which the agent is likely to contact:

    • shiny.cnsgenomics.com

    Also links to:

    • github.com

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bio Causal Genomics Mendelian Randomization loads about 2.2k tokens when it runs. Until then it costs about 95 tokens; SKILL.md has 450 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~95
When it runs · the whole SKILL.md, loaded when a task matches
~2.2k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 450 words (~2,181 tokens).

“Reference examples tested with: TwoSampleMR 0.5+, MendelianRandomization 0.9+”

— opening of SKILL.md by FreedomIntelligence
name
bio-causal-genomics-mendelian-randomization
tool_type
r
primary_tool
TwoSampleMR

Read the full SKILL.md on GitHub

Files

SKILL.md and 3 other files in skills/bio-causal-genomics-mendelian-randomization of FreedomIntelligence/OpenClaw-Medical-Skills.

  • SKILL.md
  • examples/mr_visualization.R
  • examples/twosamplemr_analysis.R
  • usage-guide.md

Open the folder on GitHubat commit b1f9b6e

Compare with similar skills

Bio Causal Genomics Mendelian Randomization next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Bio Causal Genomics Mendelian Randomization compared with similar skills
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Bidirectional Multi Phenotype Mr Research Planneraipoch/medical-research-skills1.9k—~4.4kAutomated safety check: PassMIT
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Single-Cell Initial AnalysisLigphiDonk/Oh-my--paper7391 repos~1.4kAutomated safety check: PassMIT
Ukb Ppp Region FetchClawBio/ClawBio1.2k—~4.6kAutomated safety check: PassMIT

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Questions about Bio Causal Genomics Mendelian Randomization

What does Bio Causal Genomics Mendelian Randomization do?

Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Bio Causal Genomics Mendelian Randomization is an agent skill from FreedomIntelligence/OpenClaw-Medical-Skills. Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR.

When should I use Bio Causal Genomics Mendelian Randomization?

Bio Causal Genomics Mendelian Randomization fits situations like: testing whether an exposure causally affects an outcome using genetic instruments; tasks that involve Econometrics and empirical research; tasks that involve Data analysis.

How do I install Bio Causal Genomics Mendelian Randomization in Claude Code?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-causal-genomics-mendelian-randomization -a claude-code`. Or copy the skill folder (skills/bio-causal-genomics-mendelian-randomization in FreedomIntelligence/OpenClaw-Medical-Skills) into .claude/skills/bio-causal-genomics-mendelian-randomization in your project. Claude Code loads it when a task matches its description.

How do I install Bio Causal Genomics Mendelian Randomization in Codex?

Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-causal-genomics-mendelian-randomization -a codex`. Or copy the skill folder (skills/bio-causal-genomics-mendelian-randomization in FreedomIntelligence/OpenClaw-Medical-Skills) into .agents/skills/bio-causal-genomics-mendelian-randomization in your project. Codex loads it when a task matches its description.

Can I use Bio Causal Genomics Mendelian Randomization in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-causal-genomics-mendelian-randomization -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bio-causal-genomics-mendelian-randomization, .gemini/skills/bio-causal-genomics-mendelian-randomization, .github/skills/bio-causal-genomics-mendelian-randomization and .opencode/skills/bio-causal-genomics-mendelian-randomization in your project.

What does Bio Causal Genomics Mendelian Randomization need to run?

Going by SKILL.md and its folder, Bio Causal Genomics Mendelian Randomization needs R for the scripts in its folder.

Does Bio Causal Genomics Mendelian Randomization access the network?

SKILL.md names 2 domains. In commands or code: shiny.cnsgenomics.com; the agent is likely to contact it when it follows the instructions. As links in the text: github.com. This is read from the text; nothing was executed.

Is Bio Causal Genomics Mendelian Randomization safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bio Causal Genomics Mendelian Randomization use?

No licence was found for Bio Causal Genomics Mendelian Randomization or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Bio Causal Genomics Mendelian Randomization use?

About 2.2k tokens (SKILL.md is roughly 8.7k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bio Causal Genomics Mendelian Randomization?

Skills that share tags, products or a category with Bio Causal Genomics Mendelian Randomization: Bio Workflows Causal Genomics Pipeline (GPTomics/bioSkills, 1.2k stars), Bidirectional Multi Phenotype Mr Research Planner (aipoch/medical-research-skills, 1.9k stars), Scanpy Single-Cell Analysis (davila7/claude-code-templates, 33k stars) and Single-Cell Initial Analysis (LigphiDonk/Oh-my--paper, 739 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bio Causal Genomics Mendelian Randomization?

FreedomIntelligence (a GitHub organization) maintains it in FreedomIntelligence/OpenClaw-Medical-Skills, which has 3,053 GitHub stars. The repository holds 279 skills in this directory. The repository was last updated on July 21, 2026.

Source: FreedomIntelligence/OpenClaw-Medical-Skills on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.