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Agent skill

Genomi Gnomad

by exon-research in exon-research/genomi

Fetch reusable public population allele frequencies from gnomAD for a specific variant.

Apache-2.0Auto-check passedResearch & Science

Install Genomi Gnomad

skills CLI
$ npx skills add exon-research/genomi --skill genomi-gnomad -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install exon-research/genomi genomi-gnomad --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/exon-research/genomi.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/gnomad .claude/skills/genomi-gnomad && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
genomi-gnomad
GitHub stars
484
Token cost
~638 tokens
SKILL.md length
274 words
Files
1
Skills in repo
20
Repo updated
First seen
Licence
Apache-2.0

At a glance

Fetch reusable public population allele frequencies from gnomAD for a specific variant.

  • The user asks about allele frequency
  • SKILL.md covers Activation, When to use this skill, Boundaries and Cross-Capability Synthesis, plus 1 more section
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md
  • Population stratification

What it does

Genomi Gnomad is an agent skill from exon-research/genomi. Fetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele.

Its SKILL.md is about 640 tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science. The repository describes itself as: Local-first, open-source Claude Science alternative, before Claude Science is a thing. Turn your AI agent into personal DNA expert. The licence is Apache-2.0.

When your agent uses it

  • The user asks about allele frequency
  • Population stratification
  • Rarity of a specific allele

Example prompts

  • “/genomi-gnomad”

What it can do on your machine

Read from SKILL.md and the folder at commit 1df4f5b. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md.

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Genomi Gnomad loads about 638 tokens when it runs. Until then it costs about 57 tokens; SKILL.md has 274 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~57
When it runs · the whole SKILL.md, loaded when a task matches
~638

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

The full file from exon-research/genomi at commit 1df4f5b, republished under its Apache-2.0 licence (© exon-research). 274 words, ~638 tokens.

Download SKILL.mdSave it as .claude/skills/genomi-gnomad/SKILL.md (or your agent's skills folder).
name
genomi-gnomad
description
Fetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele.
tools
genomi.invoke
mutating
true

Population Frequency (gnomAD)

Fetch public gnomAD population allele frequencies for one variant. Results are cached locally in the evidence database so subsequent queries reuse them.

Activation

To call the tool below, invoke it through the MCP dispatcher:

genomi.invoke({
  "tool": "gnomad.fetch_population_frequency",
  "params": {
    "chrom": "19",
    "pos": 44908684,
    "ref": "T",
    "alt": "C",
    "genome_build": "GRCh38"
  }
})

The dispatcher validates the params against the underlying tool's input schema and returns the underlying tool's response with an added dispatched_tool field.

When to use this skill

  • "What is the gnomAD frequency of rs429358?"
  • "Is this variant rare in gnomAD?"
  • "Allele frequency in African populations for rs1042522."
  • Any question that needs MAF, AF, population-stratified counts.

Boundaries

  • Variant-anchored only — query one allele at a time.
  • Public population data only — does not read the user's Active Genome Index.
  • Cached after first fetch — subsequent queries for the same variant reuse the local evidence store.

Cross-Capability Synthesis

A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.

Tools

gnomad.fetch_population_frequency

Fetch reusable gnomAD public population frequency for one allele and write it into evidence storage.

Use when: The agent needs gnomAD allele frequency, MAF, or population-stratified counts for a specific variant (rsID, chrom/pos/ref/alt, or VCF locus).

Why necessary: gnomAD is the canonical public population frequency source; cached results keep subsequent calls cheap.

Not for: Genome-wide rare-variant screening, ad-hoc curated annotations, anything not anchored to a specific variant.

Example prompts: What's the gnomAD frequency of rs429358? Is rs1042522 rare in East Asian populations?

Result semantics: Returns the gnomAD record with population-stratified counts and frequencies plus a populations block; writes to the local evidence database for reuse.

© exon-research, Apache-2.0. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file

Files

Just SKILL.md in skills/gnomad of exon-research/genomi.

Open the folder on GitHubat commit 1df4f5b

Compare with similar skills

Genomi Gnomad next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Genomi Gnomad compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Genomi Gnomad this skillexon-research/genomi484—~638Automated safety check: PassApache-2.0
Hypothesis Generationspacering-net/codeg3.9k14 repos~3.6kAutomated safety check: NotesMIT
GitHub Deep Researchbytedance/deer-flow84k4 repos~1.3kAutomated safety check: PassMIT
Nature Paper CardYuan1z0825/nature-skills47k2 repos~2.1kAutomated safety check: PassApache-2.0
Content Research Writerweapp-tailwindcss/weapp-tailwindcss1.9k25 repos~3.5kAutomated safety check: PassMIT
Last30daysmvanhorn/last30days-skill64k—~7.9kAutomated safety check: NotesMIT

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Categories

Questions about Genomi Gnomad

What does Genomi Gnomad do?

Fetch reusable public population allele frequencies from gnomAD for a specific variant. Genomi Gnomad is an agent skill from exon-research/genomi. Fetch reusable public population allele frequencies from gnomAD for a specific variant.

When should I use Genomi Gnomad?

Genomi Gnomad fits situations like: the user asks about allele frequency; population stratification; rarity of a specific allele.

How do I install Genomi Gnomad in Claude Code?

Run `npx skills add exon-research/genomi --skill genomi-gnomad -a claude-code`. Or copy the skill folder (skills/gnomad in exon-research/genomi) into .claude/skills/genomi-gnomad in your project. Claude Code loads it when a task matches its description.

How do I install Genomi Gnomad in Codex?

Run `npx skills add exon-research/genomi --skill genomi-gnomad -a codex`. Or copy the skill folder (skills/gnomad in exon-research/genomi) into .agents/skills/genomi-gnomad in your project. Codex loads it when a task matches its description.

Can I use Genomi Gnomad in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add exon-research/genomi --skill genomi-gnomad -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/genomi-gnomad, .gemini/skills/genomi-gnomad, .github/skills/genomi-gnomad and .opencode/skills/genomi-gnomad in your project.

What does Genomi Gnomad need to run?

SKILL.md names no scripts, command-line tools or credentials: Genomi Gnomad is instructions for the agent only.

Does Genomi Gnomad access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Genomi Gnomad safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Genomi Gnomad use?

Genomi Gnomad is published under the Apache-2.0 licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.

How many tokens does Genomi Gnomad use?

About 638 tokens (SKILL.md is roughly 2.6k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Genomi Gnomad?

Skills that share tags, products or a category with Genomi Gnomad: Hypothesis Generation (spacering-net/codeg, 3.9k stars), GitHub Deep Research (bytedance/deer-flow, 84k stars), Nature Paper Card (Yuan1z0825/nature-skills, 47k stars) and Content Research Writer (weapp-tailwindcss/weapp-tailwindcss, 1.9k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Genomi Gnomad?

exon-research (a GitHub organization) maintains it in exon-research/genomi, which has 484 GitHub stars. The repository holds 20 skills in this directory. The repository was last updated on August 31, 2026.

Source: exon-research/genomi on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.