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Agent skill

Active Genome Index

by exon-research in exon-research/genomi

Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores.

Apache-2.0Auto-check: warningsResearch & Science

Install Active Genome Index

The automated check flagged lines worth reading first. See the safety section below.

skills CLI
$ npx skills add exon-research/genomi --skill active-genome-index -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install exon-research/genomi active-genome-index --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/exon-research/genomi.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/active-genome-index .claude/skills/active-genome-index && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
active-genome-index
GitHub stars
484
Token cost
~4.3k tokens
SKILL.md length
2,089 words
Files
1
Skills in repo
20
Repo updated
First seen
Licence
Apache-2.0

At a glance

Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores.

  • Works in 4 steps: Read… → If availability.agi_intake_source_path… → If availability.agi_intake_source_path… → …
  • The session explicitly supplies a VCF/gVCF
  • SKILL.md covers Goal, Contract, Supported Sources and Cross-Capability Synthesis, plus 7 more sections
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Active Genome Index is an agent skill from exon-research/genomi. Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores. Use when the session explicitly supplies a VCF/gVCF, BAM, genome.computer .genome/1.0 bundle, 23andMe raw genotype export, AncestryDNA raw genotype export, MyHeritage raw genotype export, FamilyTreeDNA Family Finder export, Living DNA autosomal export, supported source zip/tar, or known Active Genome Index.

Its SKILL.md is about 4.3k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science, covering Bioinformatics. The repository describes itself as: Local-first, open-source Claude Science alternative, before Claude Science is a thing. Turn your AI agent into personal DNA expert. The licence is Apache-2.0.

When your agent uses it

  • The session explicitly supplies a VCF/gVCF
  • Genome.computer .genome/1.0 bundle
  • 23andMe raw genotype export
  • AncestryDNA raw genotype export

Example prompts

  • “/active-genome-index”

Workflow steps

4 steps, taken from the first numbered list in SKILL.md.

  1. Read active_genome_index.agi_intake_source_path from
  2. If availability.agi_intake_source_path is true (path is still on disk), call
  3. If availability.agi_intake_source_path is false (path moved or deleted), ask the user
  4. After reparse, call genomi.describe_context again to confirm

What it can do on your machine

Read from SKILL.md and the folder at commit 1df4f5b. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md.

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Active Genome Index loads about 4.3k tokens when it runs. Until then it costs about 113 tokens; SKILL.md has 2,089 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~113
When it runs · the whole SKILL.md, loaded when a task matches
~4.3k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check: warnings

The automated check found patterns that need a careful read before installing.

  • WarningTells the agent its actions are pre-authorized / not to stop for confirmationSKILL.md:286
    without prompting the user — this is routine maintenance.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

The full file from exon-research/genomi at commit 1df4f5b, republished under its Apache-2.0 licence (© exon-research). 2,089 words, ~4,316 tokens.

Download SKILL.mdSave it as .claude/skills/active-genome-index/SKILL.md (or your agent's skills folder).
name
active-genome-index
description
Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores. Use when the session explicitly supplies a VCF/gVCF, BAM, genome.computer .genome/1.0 bundle, 23andMe raw genotype export, AncestryDNA raw genotype export, MyHeritage raw genotype export, FamilyTreeDNA Family Finder export, Living DNA autosomal export, supported source zip/tar, or known Active Genome Index.
tools
genomi.describe_context, active_genome_index.approve_access, active_genome_index.select_user, active_genome_index.assign_user_genome, genomi.parse_source…
mutating
true

Active Genome Index

Use this skill when the user provides a genome result file, asks to parse a genome source, asks what local Active Genome Index context exists, or asks a sample-specific question that requires a user file.

Goal

Create or refresh the private Active Genome Index and local evidence stores. Interpret health meaning only after the relevant evidence skill gathers support for the user's claim.

Convention: See skills/conventions/context-routing.md. Convention: See skills/_output-rules.md.

Contract

Contract:

  • A supplied source file or an Active Genome Index explicitly approved in the current session is accessible before sample-specific work.
  • GENOMI_HOME stores durable Active Genome Index records.
  • Every genome source parsed by Genomi becomes an Active Genome Index record.
  • User/profile nicknames belong to users, not genome artifacts.
  • A user can have multiple genome records and one selected Active Genome Index.
  • A default user is auto-selected as metadata for every session using this GENOMI_HOME; its selected Active Genome Index still requires current-session approval before a private read.
  • genomi.parse_source digitizes the intake file so future inquiries use the Active Genome Index.
  • The original intake path is hidden from normal agent-facing context after parsing.
  • Parsing success creates a source-appropriate Active Genome Index for later interpretation.

Supported Sources

  • VCF/gVCF: variant callsets with VCF records, genotype fields, optional depth/quality, and possible region callability.
  • BAM: aligned sequencing reads. Genomi derives a local VCF from the reads with a matching reference FASTA, then builds an Active Genome Index for the derived callset for normal sample-specific tools.
  • FASTQ (paired-end): raw reads from sequencing services such as Nebula, Dante Labs, and Sequencing.com. Genomi auto-detects the R2 sibling, picks minimap2 (long reads) or bwa-mem2 (short reads) by the median sniffed read length, sorts the aligned BAM with samtools, then hands the BAM off to the standard BAM → derived-VCF path. Requires the wgs-alignment install purpose (or aligner binaries on PATH); a missing aligner returns requires_library_install instead of failing.
  • 23andMe raw genotype text or zip/tar archive: consumer SNP-array calls with rsid, chromosome, position, and plus-strand genotype on GRCh37.
  • genome.computer .genome/1.0 bundle directory or archive with manifest.json, schema.json, and partitioned variants.parquet records.
  • AncestryDNA raw genotype text or zip/tar archive: consumer SNP-array calls with rsid, chromosome, position, allele1, and allele2 on GRCh37/build 37.1.
  • MyHeritage raw genotype CSV or zip/tar archive: comma-delimited RSID,CHROMOSOME,POSITION,RESULT exports prefixed with a # MyHeritage DNA raw data banner, GRCh37.
  • FamilyTreeDNA Family Finder autosomal CSV or compressed/zip/tar archive: same RSID,CHROMOSOME,POSITION,RESULT columns as MyHeritage but with no banner, build encoded in the filename (_o37_), GRCh37.
  • Living DNA autosomal text or zip/tar archive: tab-separated rsid/chromosome/position/genotype rows with a # Living DNA customer genotype data banner on GRCh37.

VCF deliverables from named consumer sequencing services (Nebula Genomics, Dante Labs, Sequencing.com) are accepted through the generic VCF path; the source provider is detected from header signatures and surfaced as provider on the parse result.

Cross-Capability Synthesis

A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.

Tools

active_genome_index.classify_callset_qc

Classify genome callset shape, depth/quality field availability, and absence-claim boundaries using an Active Genome Index.

Use when: Use before broad Active Genome Index claims when the agent needs callset shape, QC fields, and absence-claim boundaries.

Why necessary: Broad Active Genome Index claims depend on whether the artifact actually contains the fields and coverage needed to support them.

active_genome_index.summarize

Summarize local parse/readiness/evidence state for an Active Genome Index.

Use when: The agent needs a compact status check for an Active Genome Index before deciding whether parsing, library-scoped evidence materialization, or evidence refresh is needed.

Why necessary: Agents need Active Genome Index readiness and artifact status before deciding whether to reuse, resume, materialize, or answer.

Example prompts: What Active Genome Index context is active?

Result semantics: Summarizes local Active Genome Index and evidence artifact state; it does not parse new input or perform interpretation.

active_genome_index.assign_user_genome

Assign an existing or supplied genome source to a user/profile and optionally make it that user's selected Active Genome Index.

Use when: A genome source or existing genomi agi should belong to a named user/profile.

Why necessary: One user can own multiple genome artifacts while selecting exactly one Active Genome Index as active for that profile.

Not for: Parsing a source into a complete Active Genome Index; use genomi.parse_source when digitization is needed.

Example prompts: Assign this VCF to Alice.

Result semantics: Links user metadata to genomi agi metadata. Supplying a source path grants scoped session access to that source's resolved Active Genome Index.

active_genome_index.clear_default_user

Clear persistent default user/profile selection for this GENOMI_HOME.

Use when: The user no longer wants any user/profile auto-selected by default.

Why necessary: Users need an explicit way to remove persistent default Active Genome Index context without deleting users or Active Genome Index artifacts.

Example prompts: Stop auto-selecting the default user.

Result semantics: Clears default=true from all known users; session selections and artifacts remain.

active_genome_index.list

List users and Active Genome Index records.

Use when: The user asks what AGIs or users exist, or gives a vague AGI lifecycle request that needs disambiguation before selecting exact records.

Result semantics: Returns structured users and active_genome_indexes; AGI records include IDs, hashes, names, typed source references, source metadata, linked users, readiness, and artifact availability. It does not approve private reads.

active_genome_index.remove

Remove confirmed Active Genome Index records, user/profile records, and Genomi-owned AGI artifacts.

Use when: The user has confirmed the exact AGI and/or user/profile record(s) to remove.

Result semantics: AGI targets remove the targeted AGI registry/session record, session access grant, user/profile AGI links, and Genomi-owned run artifacts. User targets remove user/profile metadata and default/session user selection; linked AGIs remain unless the same confirmed call also targets those AGIs. The original intake source and shared evidence database are not deleted.

genomi.parse_source

genomi.parse_source is a core genomi.* tool, documented in the root Genomi skill (SKILL.md → "Parsing A Genome Source"). This skill drives the workflow around it — select user, approve access, assign the parsed genome to a profile, and lifecycle reparse — plus the active_genome_index.* interpretation tools.

active_genome_index.rename_user

Rename a user/profile nickname.

Use when: The user wants to rename a person/profile.

Why necessary: Human-friendly names belong to users, while Active Genome Index IDs remain stable hash-based artifact identifiers.

Example prompts: Rename this user to Alice.

Result semantics: Updates one user nickname. Active Genome Index artifact IDs are unchanged.

active_genome_index.select_user

Select a user/profile for this session without granting private artifact access.

Use when: The user names a person/profile and the agent needs to make that user's selected Active Genome Index the session metadata context.

Why necessary: Selecting another user should be metadata-only until active_genome_index.approve_access grants access to that user's selected Active Genome Index.

Example prompts: Use Alice's genome context.

Result semantics: Sets the selected user and selected Active Genome Index metadata; private reads still require scoped current-session approval, including for the default user.

active_genome_index.set_default_user

Set the default user/profile for this GENOMI_HOME.

Use when: The user wants one profile's selected Active Genome Index selected as metadata by default in every session.

Why necessary: Default selection identifies one profile without selecting every genome or user; it does not grant private read access.

Example prompts: Make Alice the default user.

Result semantics: Sets exactly one default user for metadata selection. The selected Active Genome Index requires explicit approval in every session before private reads.

Show full SKILL.md (878 more words)Show less

Selection Notes

  • Use genomi.describe_context to inspect selected session context.
  • If the user supplied a source file and the answer needs sample evidence, first inspect whether the same source or a known complete Active Genome Index is already selected. Use the existing complete Active Genome Index when available; call genomi.parse_source --params '{"source":"<path>"}' only when no complete matching Active Genome Index exists or Genomi reports the Active Genome Index is incomplete.
  • If genomi.parse_source returns status="in_progress" with a job_id, keep polling genomi.check_background_job for that job. Do not switch to a capped parse or raw text scan as a substitute for the full active Active Genome Index unless the user explicitly asks for a temporary fallback.
  • Do not add max_records for user-facing inspection when a complete Active Genome Index may already exist. A capped parse is only an explicit sampling/debug choice, not the normal path for "anything notable?".
  • If a focused evidence tool returns status="requires_library_install", explain what the named library enables for the user's intent and ask whether they want it installed. Do not treat missing library data as negative evidence.
  • If the user supplied a known agi_id, call active_genome_index.approve_access --params '{"approved_by_user":true,"agi_id":"..."}' only after explicit approval for this session.
  • If the user supplied a user nickname, call active_genome_index.select_user for metadata selection, then call active_genome_index.approve_access if sample evidence is needed for that user's selected Active Genome Index.
  • For interpretation work, load the matching focused capability skill and call its capability tools through genomi.invoke.

Boundaries

  • Raw genome source files stay local.
  • Durable Active Genome Index records in GENOMI_HOME become readable only when the session explicitly approves the resolved agi_id or supplies its source path. Default user selection is metadata-only.
  • VCF/gVCF parsing does not import public sources or build whole-callset static artifacts. Use focused tools such as clinvar.match_variants, active_genome_index.classify_genotype_support, or region.retrieve_features when that evidence is needed. BAM parsing also requires local samtools and bcftools.
  • Consumer array calls support rsID/locus presence checks. Sequencing depth, genotype quality, phasing, and region callability come from sequencing-derived sources.
  • If the user asks a tiny factual question and an Active Genome Index already exists, prefer variant.resolve from the variant evidence skill to resolve the target and query the Active Genome Index.
  • If parsing already succeeded, the original file is an intake source. Future inquiries should normally use the Active Genome Index.
  • For genetics questions outside Active Genome Index workflows, use Journal source-review memory, GWAS, or normal agent research without adding a routine source-status line.

Reference pass (variants_ready → completed)

A gVCF parse returns variants_ready once every variant is stored, then appends the reference-block tail in a detached background job. At variants_ready every variant query is correct; only "is this locus confirmed reference vs not-callable" coverage answers are provisional (readiness and the individual coverage/callability/genotype-support results carry reference_pending). Don't reparse to "finish" it — poll genomi.check_background_job with the surfaced job_id, or simply re-query once readiness reports completed.

active_genome_index.build_reference_pass

Internal — do not invoke by hand. genomi.parse_source launches this automatically as a background job after a gVCF reaches variants_ready, and surfaces its job_id in the parse result's next_actions. It appends the reference-block tail to the variants_ready index and flips it to completed. It is idempotent (a no-op on an already-complete index). The only thing you do with it is poll its job_id via genomi.check_background_job if the user is waiting on reference-coverage answers.

After Parsing

Select the focused skill from the user intent:

  • ClinVar discovery: ClinVar skill
  • Specific variant/gene/rsID: variant evidence skill
  • GWAS phenotype plus rsIDs: GWAS Catalog skill
  • All-at-once dashboard / one-shot rundown: decode skill

Lifecycle: handle needs_reparse and schema_too_new automatically

genomi.describe_context (and every read op's error envelope) returns an active_genome_index_readiness block with status and a structured reason code. The agent must reconcile lifecycle state on its own before falling back to the user.

status: needs_reparse (reason: active_genome_index_needs_reparse)

The on-disk Active Genome Index was built by an older Genomi runtime than the current SCHEMA_VERSION. Reparse rebuilds it at the current schema.

  1. Read active_genome_index.agi_intake_source_path from genomi.describe_context. Check active_genome_index.availability.agi_intake_source_path.
  2. If availability.agi_intake_source_path is true (path is still on disk), call genomi.parse_source({"source": "<path-from-describe_context>"}) without prompting the user — this is routine maintenance.
  3. If availability.agi_intake_source_path is false (path moved or deleted), ask the user once: "Your Active Genome Index needs to be reparsed at the new schema, but the original source isn't at <recorded path> anymore. Send me the current path, or restore the file there." Wait for the user, then parse that path.
  4. After reparse, call genomi.describe_context again to confirm active_genome_index_readiness.status == "complete". Then continue the original request (decode, variant lookup, PharmCAT, whatever the user asked for).

status: schema_too_new (reason: active_genome_index_schema_too_new)

The Active Genome Index was built by a newer Genomi than the current process. Do not reparse — that would downgrade the Active Genome Index. Tell the user the runtime is out of date and they need to upgrade Genomi.

Incomplete (missing objects)

Continue with what's available; surface honest "Not gathered" notes in any downstream artifacts. Do not silently substitute mock or placeholder data.

Context Checks

  • Select the Active Genome Index from the session's source path, approved agi_id, or default-user metadata; approve any previously imported Active Genome Index before reading it.
  • Use an existing Active Genome Index when it answers the question.
  • Use variant.resolve for rsID, allele, locus, or region checks after parsing.
  • Treat broad candidate inventories as triage inputs.
  • Keep raw genome source content and broad match files local.

© exon-research, Apache-2.0. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file

Files

Just SKILL.md in skills/active-genome-index of exon-research/genomi.

Open the folder on GitHubat commit 1df4f5b

Compare with similar skills

Active Genome Index next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Active Genome Index compared with similar skills
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Active Genome Index this skillexon-research/genomi484—~4.3kAutomated safety check: WarnApache-2.0
Alphagenome Single Variant Analysisgoogle-deepmind/science-skills3.2k2 repos~3kAutomated safety check: NotesApache-2.0
13C Metabolic Flux AnalysisK-Dense-AI/scientific-agent-skills48k1 repos~3.2kAutomated safety check: PassMIT
Clinvar Databasegoogle-deepmind/science-skills3.2k2 repos~3.9kAutomated safety check: NotesApache-2.0
Metabolic Study Planneraiming-lab/AutoResearchClaw15k—~1.9kAutomated safety check: PassMIT
Dbsnp Databasegoogle-deepmind/science-skills3.2k2 repos~3.4kAutomated safety check: NotesApache-2.0

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Categories

Questions about Active Genome Index

What does Active Genome Index do?

Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores. Active Genome Index is an agent skill from exon-research/genomi. Register, parse, and digitize private genome source files into a local Active Genome Index and supporting evidence stores.

When should I use Active Genome Index?

Active Genome Index fits situations like: the session explicitly supplies a VCF/gVCF; genome.computer .genome/1.0 bundle; 23andMe raw genotype export; ancestryDNA raw genotype export.

How do I install Active Genome Index in Claude Code?

Run `npx skills add exon-research/genomi --skill active-genome-index -a claude-code`. Or copy the skill folder (skills/active-genome-index in exon-research/genomi) into .claude/skills/active-genome-index in your project. Claude Code loads it when a task matches its description.

How do I install Active Genome Index in Codex?

Run `npx skills add exon-research/genomi --skill active-genome-index -a codex`. Or copy the skill folder (skills/active-genome-index in exon-research/genomi) into .agents/skills/active-genome-index in your project. Codex loads it when a task matches its description.

Can I use Active Genome Index in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add exon-research/genomi --skill active-genome-index -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/active-genome-index, .gemini/skills/active-genome-index, .github/skills/active-genome-index and .opencode/skills/active-genome-index in your project.

What does Active Genome Index need to run?

SKILL.md names no scripts, command-line tools or credentials: Active Genome Index is instructions for the agent only.

Does Active Genome Index access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Active Genome Index safe to install?

Our automated static check of SKILL.md flagged 1 warning(s): tells the agent its actions are pre-authorized / not to stop for confirmation. Read the flagged lines before installing; the check is not a guarantee either way.

What licence does Active Genome Index use?

Active Genome Index is published under the Apache-2.0 licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.

How many tokens does Active Genome Index use?

About 4.3k tokens (SKILL.md is roughly 17k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Active Genome Index?

Skills that share tags, products or a category with Active Genome Index: Alphagenome Single Variant Analysis (google-deepmind/science-skills, 3.2k stars), 13C Metabolic Flux Analysis (K-Dense-AI/scientific-agent-skills, 48k stars), Clinvar Database (google-deepmind/science-skills, 3.2k stars) and Metabolic Study Planner (aiming-lab/AutoResearchClaw, 15k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Active Genome Index?

exon-research (a GitHub organization) maintains it in exon-research/genomi, which has 484 GitHub stars. The repository holds 20 skills in this directory. The repository was last updated on August 31, 2026.

Source: exon-research/genomi on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.