Dbsnp Database
google-deepmind/science-skills
A skill your agent uses when you want to look up, map, and search for short genetic variants (SNPs, indels) in NCBI's dbSNP database.
Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
Install Recombinator
$ npx skills add ClawBio/ClawBio --skill recombinator -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install ClawBio/ClawBio recombinator --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/recombinator .claude/skills/recombinator && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .claude/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/ClawBio/ClawBio/tree/main/skills/recombinatorType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add ClawBio/ClawBio --skill recombinator -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install ClawBio/ClawBio recombinator --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .agents/skills && cp -r skills-src/skills/recombinator .agents/skills/recombinator && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .agents/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add ClawBio/ClawBio --skill recombinator -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install ClawBio/ClawBio recombinator --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/skills/recombinator .cursor/skills/recombinator && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .cursor/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/ClawBio/ClawBio.git --path skills/recombinator--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add ClawBio/ClawBio --skill recombinator -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install ClawBio/ClawBio recombinator --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/skills/recombinator .gemini/skills/recombinator && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .gemini/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install ClawBio/ClawBio recombinatorInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add ClawBio/ClawBio --skill recombinator -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .github/skills && cp -r skills-src/skills/recombinator .github/skills/recombinator && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .github/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add ClawBio/ClawBio --skill recombinator -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install ClawBio/ClawBio recombinator --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/ClawBio/ClawBio.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/skills/recombinator .opencode/skills/recombinator && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "recombinator" agent skill from https://github.com/ClawBio/ClawBio/tree/main/skills/recombinator into .opencode/skills/recombinator/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "recombinator", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
Facts
- Skill name
recombinator- GitHub stars
- 1.2k
- Used in
- 1 other repo
- Token cost
- ~651 tokens
- SKILL.md length
- 163 words
- Files
- 2
- Skills in repo
- 104
- Repo updated
- First seen
- Licence
- MIT
At a glance
Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
- Works in 6 steps: Mendelian segregation: one allele… → De novo mutation: configurable rate per… → Sex determination: 50/50 coin flip (XY… → …
- Tasks that involve Bioinformatics
- SKILL.md covers Purpose, How It Works, Input and Output, plus 2 more sections
- Runs Python scripts from its folder; calls python
What it does
Recombinator is an agent skill from ClawBio/ClawBio. Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
Its SKILL.md is about 650 tokens, which your agent loads only when the skill is triggered. The skill folder holds 1 other file (for example `recombinator.py`).
It sits in Research & Science, covering Bioinformatics. The repository describes itself as: 🦖 ClawBio - The first bioinformatics-native AI agent skill library. Local-first. Reproducible. Open. Free. The licence is MIT.
When your agent uses it
- Tasks that involve Bioinformatics
Example prompts
- “/recombinator”
Requirements
- Python 3
Workflow steps
6 steps, taken from the first numbered list in SKILL.md.
- Mendelian segregation: one allele inherited from each parent per locus
- De novo mutation: configurable rate per locus (default 0.1%), with hotspot
- Sex determination: 50/50 coin flip (XY or XX).
- Trait inference: reverse-map offspring genotype back to trait scores using
- Clinical evaluation: check offspring genotype against disease registry for
- Health score: computed from cumulative fitness costs of clinical conditions.
What it can do on your machine
Read from SKILL.md and the folder at commit 5e045e3. It shows what the files ask for, not the result of running them.
Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
Ships script files (Python), which the agent can run.
Shell commands in SKILL.md call:
python
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Context cost
Recombinator loads about 651 tokens when it runs. Until then it costs about 29 tokens; SKILL.md has 163 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
Safety
Auto-check passed
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
SKILL.md
The full file from ClawBio/ClawBio at commit 5e045e3, republished under its MIT licence (© ClawBio). 163 words, ~651 tokens.
Download SKILL.mdSave it as
.claude/skills/recombinator/SKILL.md (or your agent's skills folder). This skill also uses 1 other file; get the full folder from GitHub.- name
- recombinator
- description
- Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
- license
- MIT
- metadata.version
- 0.1.0
- metadata.author
- Manuel Corpas
- metadata.tags
- genomebook, recombination, meiosis, mutation, offspring, clinical-genetics
🧪 Recombinator
Purpose
Produce offspring genomes from selected parent pairs via simulated meiotic recombination. Models Mendelian segregation, de novo mutation, sex determination, and clinical evaluation against a disease registry.
How It Works
- Mendelian segregation: one allele inherited from each parent per locus (random selection simulating independent assortment).
- De novo mutation: configurable rate per locus (default 0.1%), with hotspot multipliers for cognitive, immune, and metabolic loci. Mutations are classified as disease-risk, protective, or neutral.
- Sex determination: 50/50 coin flip (XY or XX).
- Trait inference: reverse-map offspring genotype back to trait scores using the trait registry, accounting for dominance models.
- Clinical evaluation: check offspring genotype against disease registry for penetrance, onset probability, and fitness cost.
- Health score: computed from cumulative fitness costs of clinical conditions.
Input
- Two parent
.genome.jsonfiles (one Male, one Female) GENOMEBOOK/DATA/trait_registry.jsonGENOMEBOOK/DATA/disease_registry.json
Output
- Offspring
.genome.jsonwith:- Inherited loci and alleles
- Mutation log
- Inferred trait scores
- Clinical history
- Health score (0.0 to 1.0)
CLI Usage
# Demo: breed Einstein x Anning, produce 3 offspring
python skills/recombinator/recombinator.py --demo
# Breed specific parents
python skills/recombinator/recombinator.py \
--father einstein-g0 --mother anning-g0 --offspring 3
# Custom generation number
python skills/recombinator/recombinator.py \
--father einstein-g0 --mother curie-g0 --offspring 2 --generation 1Output Format
ID: g1-001-a3f2c1
Sex: Female (XX)
Health: 0.9500
Mutations: 1
- COMT_Val158Met: G->A (neutral, from mother)
Conditions: 0
Top traits:
- curiosity: 0.92
- analytical_thinking: 0.88
- persistence: 0.85© ClawBio, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file
Files
SKILL.md and 1 other file in skills/recombinator of ClawBio/ClawBio.
- SKILL.md
- recombinator.py
Open the folder on GitHubat commit 5e045e3
Used in 1 other repository
We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders, from 1 other GitHub owner. This page covers the copy in ClawBio/ClawBio, which our catalogue first saw on October 7, 2026.
Compare with similar skills
Recombinator next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Recombinator this skillClawBio/ClawBio | 1.2k | 1 repos | ~651 | Automated safety check: Pass | MIT | |
| Dbsnp Databasegoogle-deepmind/science-skills | 3.2k | 3 repos | ~3.4k | Automated safety check: Notes | Apache-2.0 | |
| Metabolic Study Planneraiming-lab/AutoResearchClaw | 15k | — | ~1.9k | Automated safety check: Pass | MIT | |
| 13C Metabolic Flux AnalysisK-Dense-AI/scientific-agent-skills | 48k | 1 repos | ~3.2k | Automated safety check: Pass | MIT | |
| Alphagenome Single Variant Analysisgoogle-deepmind/science-skills | 3.2k | 2 repos | ~3k | Automated safety check: Notes | Apache-2.0 | |
| MFA Pipeline Orchestratoraiming-lab/AutoResearchClaw | 15k | — | ~923 | Automated safety check: Pass | MIT |
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Runs a metabolic flux analysis from model loading to phenotype prediction and figures by handing work to four sub-agents in sequence.
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Related
Categories
Questions about Recombinator
What does Recombinator do?
Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation. Recombinator is an agent skill from ClawBio/ClawBio.
When should I use Recombinator?
Recombinator fits situations like: tasks that involve Bioinformatics.
How do I install Recombinator in Claude Code?
Run `npx skills add ClawBio/ClawBio --skill recombinator -a claude-code`. Or copy the skill folder (skills/recombinator in ClawBio/ClawBio) into .claude/skills/recombinator in your project. Claude Code loads it when a task matches its description.
How do I install Recombinator in Codex?
Run `npx skills add ClawBio/ClawBio --skill recombinator -a codex`. Or copy the skill folder (skills/recombinator in ClawBio/ClawBio) into .agents/skills/recombinator in your project. Codex loads it when a task matches its description.
Can I use Recombinator in Cursor, Gemini CLI or GitHub Copilot?
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add ClawBio/ClawBio --skill recombinator -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/recombinator, .gemini/skills/recombinator, .github/skills/recombinator and .opencode/skills/recombinator in your project.
What does Recombinator need to run?
Going by SKILL.md and its folder, Recombinator needs Python for the scripts in its folder and the command-line tools its instructions call (python). Our summary lists: Python 3.
Does Recombinator access the network?
SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.
Is Recombinator safe to install?
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
What licence does Recombinator use?
Recombinator is published under the MIT licence (declared in SKILL.md). It allows redistribution, so the full SKILL.md is shown on this page.
How many tokens does Recombinator use?
About 651 tokens (SKILL.md is roughly 2.6k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.
What are the alternatives to Recombinator?
Skills that share tags, products or a category with Recombinator: Dbsnp Database (google-deepmind/science-skills, 3.2k stars), Metabolic Study Planner (aiming-lab/AutoResearchClaw, 15k stars), 13C Metabolic Flux Analysis (K-Dense-AI/scientific-agent-skills, 48k stars) and Alphagenome Single Variant Analysis (google-deepmind/science-skills, 3.2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
Who maintains Recombinator?
ClawBio (a GitHub organization) maintains it in ClawBio/ClawBio, which has 1,154 GitHub stars. The repository holds 104 skills in this directory. The repository was last updated on October 7, 2026.
Source: ClawBio/ClawBio on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.