Agent skill

Bioconductor Zenith

by bioMate-AI in bioMate-AI/biomate-bioconductor-kb

Zenith performs gene set analysis on the result of differential expression using linear (mixed) modeling with dream by considering the correlation between gene expression traits.

Custom licenceAuto-check passedResearch & Science

Install Bioconductor Zenith

skills CLI
$ npx skills add bioMate-AI/biomate-bioconductor-kb --skill bioconductor-zenith -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install bioMate-AI/biomate-bioconductor-kb bioconductor-zenith --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/bioMate-AI/biomate-bioconductor-kb.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/transcriptomics/zenith .claude/skills/bioconductor-zenith && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
bioconductor-zenith
GitHub stars
804
Token cost
~1.1k tokens
SKILL.md length
375 words
Files
1
Skills in repo
112
Repo updated
First seen
Licence
Custom licence

At a glance

Zenith performs gene set analysis on the result of differential expression using linear (mixed) modeling with dream by considering the correlation between gene expression traits.

  • Tasks that involve Bioinformatics
  • SKILL.md covers Workflows, When to Use, When NOT to Use and Data Requirements, plus 6 more sections
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Bioconductor Zenith is an agent skill from bioMate-AI/biomate-bioconductor-kb. Zenith performs gene set analysis on the result of differential expression using linear (mixed) modeling with dream by considering the correlation between gene expression traits. This package implements the camera method from the limma package proposed by Wu and Smyth (2012). Zenith is a simple extension of camera to be compatible with linear mixed models implemented in variancePartition::dream().

Its SKILL.md is about 1.1k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science, covering Bioinformatics. It works with Ensembl. The repository describes itself as: BioMate-KB Bioconductor Skills — 200 packages (top 100 by downloads + 100 rising stars) as vignette-grounded Claude/agent skills, with per-package workflow recipes.

When your agent uses it

  • Tasks that involve Bioinformatics

Example prompts

  • “/bioconductor-zenith”

What it can do on your machine

Read from SKILL.md and the folder at commit c9bd4d8. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md (its code samples are r).

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    Links to these hosts (documentation or services it may open):

    • bioconductor.org

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Bioconductor Zenith loads about 1.1k tokens when it runs. Until then it costs about 106 tokens; SKILL.md has 375 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~106
When it runs · the whole SKILL.md, loaded when a task matches
~1.1k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Its licence (Custom licence) doesn't allow us to republish the file, so here is its outline and opening line. It has 375 words (~1,144 tokens).

“Perform gene set enrichment analysis on differential expression results from a linear mixed model fit with dream and visualize the results.”

— opening of SKILL.md by bioMate-AI, Custom licence
name
bioconductor-zenith
when_to_use
Use when: Example usage of zenith on GEUVAIDIS RNA-seq; Example usage of zenith on RNA-seq; Differential expression analysis (zenith); Data normalization and…
user-invocable
false

Read the full SKILL.md on GitHub

Files

Just SKILL.md in skills/transcriptomics/zenith of bioMate-AI/biomate-bioconductor-kb.

Open the folder on GitHubat commit c9bd4d8

Compare with similar skills

Bioconductor Zenith next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Bioconductor Zenith compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Bioconductor Zenith this skillbioMate-AI/biomate-bioconductor-kb804—~1.1kAutomated safety check: PassCustom licence
External API ChangeGuyTeichman/RNAlysis139—~1.8kAutomated safety check: PassMIT
Ensembl Databasedavila7/claude-code-templates33k10 repos~2.1kAutomated safety check: PassMIT
Annotating Variantsmaziyarpanahi/openmed5.5k—~2.1kAutomated safety check: PassApache-2.0
Ggetdavila7/claude-code-templates33k10 repos~6.3kAutomated safety check: PassMIT
Ensembl Databasegoogle-deepmind/science-skills3.2k1 repos~2.2kAutomated safety check: PassApache-2.0

Similar skills

  • External API Change

    GuyTeichman/RNAlysis

    Workflow for fixing or changing RNAlysis code that talks to an EXTERNAL WEB SERVICE — UniProt, Ensembl, PANTHER, PhylomeDB, OrthoInspector, KEGG, or GO.

    139 GitHub stars~1.8k tokensUpdated 12 days ago
    Research & ScienceAuto-check passed
  • Ensembl Database

    davila7/claude-code-templates

    Query Ensembl genome database REST API for 250+ species. An agent skill from davila7/claude-code-templates.

    33k GitHub starsUsed in 10 repos~2.1k tokens
    Research & ScienceAuto-check passed
  • Annotating Variants

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    Annotates VCF variants and normalizes HGVS nomenclature with public, license-free annotators (Ensembl VEP REST, VEP/SnpEff/ANNOVAR offline) and links variants to gnomAD population frequencies and…

    5.5k GitHub stars~2.1k tokensUpdated yesterday
    Research & ScienceAuto-check passed
  • Gget

    davila7/claude-code-templates

    CLI/Python toolkit for rapid bioinformatics queries. An agent skill from davila7/claude-code-templates.

    33k GitHub starsUsed in 10 repos~6.3k tokens
    Research & ScienceAuto-check passed
  • Ensembl Database

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    Query the Ensembl database to resolve gene, transcript, and protein IDs, fetch genomic or protein sequences, retrieve gene structures (exons), and get variant consequence and effect predictions (VEP).

    3.2k GitHub starsUsed in 1 repo~2.2k tokens
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  • gget CLI and Python workflow for quick genomic database queries, sequence lookup, BLAST-style searches, enrichment checks, and reproducible bioinformatics evidence logs.

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All 112 skills in this repo
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  • Bioconductor Asurat

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  • Bioconductor Awst

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    We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples.

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  • Bioconductor Bandle

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    The Bandle package enables the analysis and visualisation of differential localisation experiments using mass-spectrometry data.

    804 GitHub stars~1.3k tokensUpdated 3 mo ago
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  • Bioconductor Batchelor

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Works with

Questions about Bioconductor Zenith

What does Bioconductor Zenith do?

Zenith performs gene set analysis on the result of differential expression using linear (mixed) modeling with dream by considering the correlation between gene expression traits. Bioconductor Zenith is an agent skill from bioMate-AI/biomate-bioconductor-kb. Zenith performs gene set analysis on the result of differential expression using linear (mixed) modeling with dream by considering the correlation between gene expression traits.

When should I use Bioconductor Zenith?

Bioconductor Zenith fits situations like: tasks that involve Bioinformatics.

How do I install Bioconductor Zenith in Claude Code?

Run `npx skills add bioMate-AI/biomate-bioconductor-kb --skill bioconductor-zenith -a claude-code`. Or copy the skill folder (skills/transcriptomics/zenith in bioMate-AI/biomate-bioconductor-kb) into .claude/skills/bioconductor-zenith in your project. Claude Code loads it when a task matches its description.

How do I install Bioconductor Zenith in Codex?

Run `npx skills add bioMate-AI/biomate-bioconductor-kb --skill bioconductor-zenith -a codex`. Or copy the skill folder (skills/transcriptomics/zenith in bioMate-AI/biomate-bioconductor-kb) into .agents/skills/bioconductor-zenith in your project. Codex loads it when a task matches its description.

Can I use Bioconductor Zenith in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add bioMate-AI/biomate-bioconductor-kb --skill bioconductor-zenith -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/bioconductor-zenith, .gemini/skills/bioconductor-zenith, .github/skills/bioconductor-zenith and .opencode/skills/bioconductor-zenith in your project.

What does Bioconductor Zenith need to run?

SKILL.md names no scripts, command-line tools or credentials: Bioconductor Zenith is instructions for the agent only.

Does Bioconductor Zenith access the network?

SKILL.md names 1 domain. As links in the text: bioconductor.org. This is read from the text; nothing was executed.

Is Bioconductor Zenith safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Bioconductor Zenith use?

Bioconductor Zenith has a licence file (the repository's licence) that doesn't match a standard licence. Read it on GitHub before reusing the skill.

How many tokens does Bioconductor Zenith use?

About 1.1k tokens (SKILL.md is roughly 4.6k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Bioconductor Zenith?

Skills that share tags, products or a category with Bioconductor Zenith: External API Change (GuyTeichman/RNAlysis, 139 stars), Ensembl Database (davila7/claude-code-templates, 33k stars), Annotating Variants (maziyarpanahi/openmed, 5.5k stars) and Gget (davila7/claude-code-templates, 33k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Bioconductor Zenith?

bioMate-AI (a GitHub organization) maintains it in bioMate-AI/biomate-bioconductor-kb, which has 804 GitHub stars. The repository holds 112 skills in this directory. The repository was last updated on June 20, 2026.

Source: bioMate-AI/biomate-bioconductor-kb on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.