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| # | Skill | Repository | Stars | Used in | Tokens | Auto-check | Licence | Updated |
|---|---|---|---|---|---|---|---|---|
| 1 | Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. | google-deepmind/ | 3.2k | 2 repos | ~3k | Automated safety check: Notes | Apache-2.0 | 23 days ago |
| 2 | Estimates reaction fluxes inside cells from steady-state carbon-13 labeling data with a bundled mfapy-based solver, and reports which fluxes the data pin down. | K-Dense-AI/ | 48k | 1 repo | ~3.2k | Automated safety check: Pass | MIT | 4 days ago |
| 3 | A skill your agent uses when designing, reviewing, or implementing single-cell RNA-seq QC in Python or R with a human-in-the-loop, data-driven approach. | xuzhougeng/ | 1k | — | ~1.6k | Automated safety check: Pass | AGPL-3.0 | today |
| 4 | Generate sashimi-style genome visualization plots (coverage, line, heatmap, IGV read-by-read, HiC, circRNA, motif) from BAM/bigWig/depth/HiC inputs. | ygidtu/ | 109 | — | ~1.9k | Automated safety check: Pass | BSD-3-Clause | 13 days ago |
| 5 | Fine-tune or transfer-learn AlphaGenome-PyTorch on custom genomic data — pick a mode (linear probe, LoRA, Locon, full), train on BigWig tracks with agt finetune, use adapters, delta checkpoints… | genomicsxai/ | 162 | — | ~1k | Automated safety check: Pass | Apache-2.0 | 23 days ago |
| 6 | Queries the UniProt REST API directly to search proteins, fetch FASTA sequences, map IDs between databases and read Swiss-Prot and TrEMBL entries. | davila7/ | 32k | 14 repos | ~1.7k | Automated safety check: Pass | MIT | today |
| 7 | Run AlphaGenome-PyTorch to get genomic track predictions — via the agt predict CLI (single locus, BED regions, whole chromosomes, raw FASTA sequences, or per-gene count tables/AnnData), variant… | genomicsxai/ | 162 | — | ~868 | Automated safety check: Pass | Apache-2.0 | 23 days ago |
| 8 | End-to-end 10x Visium spatial transcriptomics analysis workflow with staged execution and human review gates. | QING1105/ | 101 | — | ~1.4k | Automated safety check: Pass | MIT | 1 mo ago |
| 9 | Guides use of deepTools on sequencing data: BAM to bigWig conversion, QC, sample correlation, and heatmaps or profiles around TSS and peaks for ChIP-seq, RNA-seq and ATAC-seq. | davila7/ | 32k | 12 repos | ~4.5k | Automated safety check: Pass | MIT | today |
| 10 | Runs flux balance analysis and related constraint-based simulations on a COBRApy metabolic model, from standard FBA to gene knockouts and carbon source swaps. | aiming-lab/ | 15k | — | ~2.1k | Automated safety check: Pass | MIT | 1 mo ago |
| 11 | Manages biological datasets with LaminDB: versioned artifacts, run lineage, ontology-based annotation, schema validation and links to workflow managers and ML tools. | davila7/ | 32k | 12 repos | ~3.6k | Automated safety check: Pass | MIT | today |
| 12 | Runs differential gene expression analysis on bulk RNA-seq counts with PyDESeq2: design formulas, Wald tests, FDR correction and volcano or MA plots. | davila7/ | 32k | 11 repos | ~4k | Automated safety check: Pass | MIT | today |
| 13 | Guides your agent through building, editing, comparing and drawing phylogenetic trees with the ETE Python toolkit, including orthology calls and NCBI taxonomy lookups. | davila7/ | 32k | 11 repos | ~4.5k | Automated safety check: Notes | MIT | today |
| 14 | Works with genomic intervals using gtars, a Rust toolkit with Python bindings: overlap detection, coverage tracks, tokenization for ML models and reference sequences. | davila7/ | 32k | 11 repos | ~1.9k | Automated safety check: Pass | MIT | today |
| 15 | 15.Pyopenms Python interface to OpenMS for mass spectrometry data analysis. | davila7/ | 32k | 11 repos | ~1.4k | Automated safety check: Pass | MIT | today |
| 16 | 16.Anndata This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling… | davila7/ | 32k | 11 repos | ~2.5k | Automated safety check: Pass | MIT | today |
| 17 | 17.Bioservices Primary Python tool for 40+ bioinformatics services. An agent skill from davila7/claude-code-templates. | davila7/ | 32k | 10 repos | ~2.5k | Automated safety check: Pass | MIT | today |
| 18 | Turns raw flux balance analysis output and a COBRApy model into gene essentiality maps, phenotypic phase planes, flux sampling results, pathway summaries and secretion predictions. | aiming-lab/ | 15k | — | ~2.3k | Automated safety check: Pass | MIT | 1 mo ago |
| 19 | 19.Biopython Primary Python toolkit for molecular biology. An agent skill from davila7/claude-code-templates. | davila7/ | 32k | 12 repos | ~3.4k | Automated safety check: Pass | MIT | today |
| 20 | 20.Gget CLI/Python toolkit for rapid bioinformatics queries. An agent skill from davila7/claude-code-templates. | davila7/ | 32k | 10 repos | ~6.3k | Automated safety check: Pass | MIT | today |
| 21 | DNAnexus cloud genomics platform. An agent skill from davila7/claude-code-templates. | davila7/ | 32k | 11 repos | ~2.6k | Automated safety check: Pass | MIT | today |
| 22 | Latch platform for bioinformatics workflows. An agent skill from davila7/claude-code-templates. | davila7/ | 32k | 11 repos | ~2.4k | Automated safety check: Pass | MIT | today |
| 23 | Load when correcting batch effects in bulk expression using R sva ComBat or the legacy Python parametric approximation. | TianGzlab/ | 161 | — | ~1.2k | Automated safety check: Pass | Apache-2.0 | yesterday |
| 24 | Runs quality control on a COBRApy genome-scale metabolic model before flux analysis, checking mass and charge balance, biomass feasibility, dead ends, thermodynamic loops and GPR rules. | aiming-lab/ | 15k | — | ~2k | Automated safety check: Pass | MIT | 1 mo ago |
| 25 | Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. | GPTomics/ | 1.2k | 2 repos | ~2.4k | Automated safety check: Pass | MIT | 1 mo ago |
| 26 | Sort alignment files by coordinate or read name using samtools and pysam. | GPTomics/ | 1.2k | 2 repos | ~2.6k | Automated safety check: Pass | MIT | 1 mo ago |
| 27 | Builds, registers, debugs, and operates bioinformatics workflows on Latch using the Python SDK, CLI, Latch Data and Registry, Nextflow, Snakemake, programmatic execution, and Latch MCP. | K-Dense-AI/ | 48k | 1 repo | ~2.5k | Automated safety check: Notes | MIT | 4 days ago |
| 28 | 28.Pydeseq2 Performs bulk RNA-seq differential expression analysis with PyDESeq2, including count validation, formula designs, explicit contrasts, Wald tests, FDR correction, coefficient-matched LFC shrinkage… | K-Dense-AI/ | 48k | 1 repo | ~2.6k | Automated safety check: Notes | MIT | 4 days ago |
| 29 | Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. | GPTomics/ | 1.2k | 2 repos | ~3.7k | Automated safety check: Pass | MIT | 1 mo ago |
| 30 | 30.Scanpy Performs Scanpy single-cell RNA-seq QC, normalization, HVG selection, PCA/UMAP/t-SNE, clustering, exploratory marker ranking, pseudobulk preparation, visualization, and Seurat or… | K-Dense-AI/ | 48k | 1 repo | ~5.1k | Automated safety check: Pass | BSD-3-Clause | 4 days ago |
| 31 | gget CLI and Python workflow for quick genomic database queries, sequence lookup, BLAST-style searches, enrichment checks, and reproducible bioinformatics evidence logs. | affaan-m/ | 276k | 1 repo | ~1.3k | Automated safety check: Pass | MIT | 4 days ago |
| 32 | 32.Bioservices Provides a Python interface to bioinformatics services including UniProt, KEGG, ChEMBL, Reactome, QuickGO, and UniChem. | K-Dense-AI/ | 48k | 1 repo | ~3k | Automated safety check: Notes | MIT | 4 days ago |
| 33 | 33.Geniml Supports audited local Geniml genomic-interval workflows: validate BED and universe contracts, plan Region2Vec or scEmbed runs, inspect model/tokenizer compatibility, and assess consensus universes. | K-Dense-AI/ | 48k | 1 repo | ~4k | Automated safety check: Notes | MIT | 4 days ago |
| 34 | 34.Gget Queries 20+ bioinformatics resources through CLI/Python. An agent skill from K-Dense-AI/scientific-agent-skills. | K-Dense-AI/ | 48k | 1 repo | ~2.8k | Automated safety check: Notes | BSD-2-Clause | 4 days ago |
| 35 | 35.Gtars Supports Gtars for local genomic interval models and set algebra, overlaps and counts, consensus and coverage, tokenization, fragment processing, and refget/BEDbase planning across Python, Rust, and… | K-Dense-AI/ | 48k | 1 repo | ~3.8k | Automated safety check: Notes | MIT | 4 days ago |
| 36 | Builds and analyzes phylogenetic trees using MAFFT multiple sequence alignment, IQ-TREE maximum likelihood with ModelFinder and branch support, and FastTree approximate inference. | K-Dense-AI/ | 48k | 1 repo | ~2.3k | Automated safety check: Pass | MIT | 4 days ago |
| 37 | 37.Pyopenms Processes mass spectrometry data with pyOpenMS. An agent skill from K-Dense-AI/scientific-agent-skills. | K-Dense-AI/ | 48k | 1 repo | ~3.1k | Automated safety check: Notes | BSD-3-Clause | 4 days ago |
| 38 | 38.Pysam Provides Python/HTSlib workflows for genomic files. An agent skill from K-Dense-AI/scientific-agent-skills. | K-Dense-AI/ | 48k | 1 repo | ~3.4k | Automated safety check: Notes | MIT | 4 days ago |
| 39 | 39.Tiledbvcf Stores and retrieves genomic variant calls with TileDB-VCF. An agent skill from K-Dense-AI/scientific-agent-skills. | K-Dense-AI/ | 48k | 1 repo | ~3.5k | Automated safety check: Pass | MIT | 4 days ago |
| 40 | 40.Biopython Provides Biopython workflows for sequence manipulation, file parsing (FASTA/GenBank/PDB), phylogenetics, and programmatic NCBI/PubMed access (Bio.Entrez). | K-Dense-AI/ | 48k | 1 repo | ~4.3k | Automated safety check: Notes | MIT | 4 days ago |
| 41 | 41.Anndata Handles annotated matrices in single-cell analysis, .h5ad and Zarr files, and integration with the scverse ecosystem. | K-Dense-AI/ | 48k | 1 repo | ~3.9k | Automated safety check: Notes | BSD-3-Clause | 4 days ago |
| 42 | A skill your agent uses when querying biomedical databases (UniProt, ClinVar, gnomAD, PDB, Reactome, Open Targets, etc.) via the Biomni AgentCore Gateway MCP server. | aws-samples/ | 274 | — | ~3.1k | Automated safety check: Pass | MIT-0 | 7 days ago |
| 43 | 43.Biopython Computational molecular biology library (sequence I/O, alignment, phylogenetics). | lamm-mit/ | 244 | — | ~3.9k | Automated safety check: Pass | Apache-2.0 | 1 mo ago |
| 44 | 44.Fastreer Phylogenetic distance matrices and trees from VCF or FASTA data using the fastreeR hybrid Java/Python toolkit (VCF2TREE, VCF2DIST, DIST2TREE, FASTA2DIST). | ClawBio/ | 1.2k | 1 repo | ~3.5k | Automated safety check: Notes | GPL-3.0 | today |
| 45 | A skill your agent uses when creating, migrating, or debugging pixi environments, especially for scientific Python, bioinformatics, single-cell analysis, CUDA/PyTorch, Jupyter/VS Code kernels… | xuzhougeng/ | 1k | — | ~3.7k | Automated safety check: Pass | AGPL-3.0 | today |
| 46 | 46.Scikit Bio Python library for biology: sequence manipulation (DNA/RNA/protein), pairwise/multiple alignment, phylogenetic trees (NJ, UPGMA), diversity (Shannon, Faith PD, Bray-Curtis, UniFrac), ordination… | jaechang-hits/ | 371 | — | ~4.4k | Automated safety check: Pass | BSD-3-Clause | 10 days ago |
| 47 | Generate R/Python code for volcano plots from DEG (Differentially Expressed Genes) analysis results. | aipoch/ | 2k | — | ~2.5k | Automated safety check: Pass | MIT | 22 days ago |
| 48 | Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or Enformer. | GPTomics/ | 1.2k | 2 repos | ~5k | Automated safety check: Pass | MIT | 1 mo ago |