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Agent skill

Tooluniverse Polygenic Risk Score

by wu-yc in wu-yc/LabClaw

Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics.

No licenceAuto-check passedResearch & Science

Install Tooluniverse Polygenic Risk Score

skills CLI
$ npx skills add wu-yc/LabClaw --skill tooluniverse-polygenic-risk-score -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install wu-yc/LabClaw tooluniverse-polygenic-risk-score --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/wu-yc/LabClaw.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/bio/tooluniverse-polygenic-risk-score .claude/skills/tooluniverse-polygenic-risk-score && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
tooluniverse-polygenic-risk-score
GitHub stars
1.1k
Used in
2 other repos
Token cost
~3.7k tokens
SKILL.md length
1,632 words
Files
1
Skills in repo
68
Repo updated
First seen
Licence
None found

At a glance

Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics.

  • Works in 6 steps: Trait Selection → Association Collection → Effect Size Extraction → …
  • Asked to calculate polygenic risk scores
  • SKILL.md covers Overview, Methodology, Data Sources and Key Concepts, plus 4 more sections
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Tooluniverse Polygenic Risk Score is an agent skill from wu-yc/LabClaw. Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Calculates genetic risk profiles, interprets PRS percentiles, and assesses disease predisposition across conditions including type 2 diabetes, coronary artery disease, and Alzheimer's disease. Use when asked to calculate polygenic risk scores, interpret genetic risk for complex diseases, build custom PRS from GWAS data, or answer questions like "What is my genetic predisposition to breast cancer?"

Its SKILL.md is about 3.7k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science, covering Bioinformatics and Data analysis. The repository describes itself as: LabClaw – Operating Layer for LabOS (Stanford-Princeton AI Co-Scientists).

When your agent uses it

  • Asked to calculate polygenic risk scores
  • Interpret genetic risk for complex diseases
  • Build custom PRS from GWAS data
  • Answer questions like What is my genetic predisposition to breast cancer?

Example prompts

  • “What is my genetic predisposition to breast cancer?”
  • “/tooluniverse-polygenic-risk-score”

Requirements

  • Python 3

Workflow steps

6 steps, taken from the step headings in SKILL.md.

  1. Trait Selection
  2. Association Collection
  3. Effect Size Extraction
  4. SNP Filtering
  5. Score Calculation
  6. Risk Interpretation

What it can do on your machine

Read from SKILL.md and the folder at commit df37802. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md (its code samples are python).

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    Links to these hosts (documentation or services it may open):

    • pgscatalog.org
    • ldsc.broadinstitute.org
    • prsice.info
    • ebi.ac.uk

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Tooluniverse Polygenic Risk Score loads about 3.7k tokens when it runs. Until then it costs about 134 tokens; SKILL.md has 1,632 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~134
When it runs · the whole SKILL.md, loaded when a task matches
~3.7k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Without a licence we can't republish the file, so here is its outline and opening line. It has 1,632 words (~3,662 tokens).

“Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data.”

— opening of SKILL.md by wu-yc
name
tooluniverse-polygenic-risk-score

Read the full SKILL.md on GitHub

Files

Just SKILL.md in skills/bio/tooluniverse-polygenic-risk-score of wu-yc/LabClaw.

Open the folder on GitHubat commit df37802

Used in 2 other repositories

We found 2 copies of this SKILL.md (exact, near-identical or edited) in other folders, from 2 other GitHub owners. This page covers the copy in wu-yc/LabClaw, which our catalogue first saw on October 7, 2026.

Compare with similar skills

Tooluniverse Polygenic Risk Score next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Tooluniverse Polygenic Risk Score compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Tooluniverse Polygenic Risk Score this skillwu-yc/LabClaw1.1k2 repos~3.7kAutomated safety check: PassNone
Scanpy Single-Cell Analysisdavila7/claude-code-templates33k15 repos~2.8kAutomated safety check: PassMIT
Single-Cell Initial AnalysisLigphiDonk/Oh-my--paper7391 repos~1.4kAutomated safety check: PassMIT
Ukb Ppp Region FetchClawBio/ClawBio1.2k—~4.6kAutomated safety check: PassMIT
Gwas PipelineClawBio/ClawBio1.2k1 repos~1.4kAutomated safety check: PassMIT
Lncrna Regulatory Network Construction Analysisaipoch/medical-research-skills1.9k—~2.7kAutomated safety check: PassMIT

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Categories

Questions about Tooluniverse Polygenic Risk Score

What does Tooluniverse Polygenic Risk Score do?

Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Tooluniverse Polygenic Risk Score is an agent skill from wu-yc/LabClaw. Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics.

When should I use Tooluniverse Polygenic Risk Score?

Tooluniverse Polygenic Risk Score fits situations like: asked to calculate polygenic risk scores; interpret genetic risk for complex diseases; build custom PRS from GWAS data; answer questions like What is my genetic predisposition to breast cancer?.

How do I install Tooluniverse Polygenic Risk Score in Claude Code?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-polygenic-risk-score -a claude-code`. Or copy the skill folder (skills/bio/tooluniverse-polygenic-risk-score in wu-yc/LabClaw) into .claude/skills/tooluniverse-polygenic-risk-score in your project. Claude Code loads it when a task matches its description.

How do I install Tooluniverse Polygenic Risk Score in Codex?

Run `npx skills add wu-yc/LabClaw --skill tooluniverse-polygenic-risk-score -a codex`. Or copy the skill folder (skills/bio/tooluniverse-polygenic-risk-score in wu-yc/LabClaw) into .agents/skills/tooluniverse-polygenic-risk-score in your project. Codex loads it when a task matches its description.

Can I use Tooluniverse Polygenic Risk Score in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add wu-yc/LabClaw --skill tooluniverse-polygenic-risk-score -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/tooluniverse-polygenic-risk-score, .gemini/skills/tooluniverse-polygenic-risk-score, .github/skills/tooluniverse-polygenic-risk-score and .opencode/skills/tooluniverse-polygenic-risk-score in your project.

What does Tooluniverse Polygenic Risk Score need to run?

SKILL.md names no scripts, command-line tools or credentials: Tooluniverse Polygenic Risk Score is instructions for the agent only. Our summary lists: Python 3.

Does Tooluniverse Polygenic Risk Score access the network?

SKILL.md names 4 domains. As links in the text: pgscatalog.org, ldsc.broadinstitute.org, prsice.info and ebi.ac.uk. This is read from the text; nothing was executed.

Is Tooluniverse Polygenic Risk Score safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Tooluniverse Polygenic Risk Score use?

No licence was found for Tooluniverse Polygenic Risk Score or its repository. Without one, default copyright applies: ask the author before reusing or redistributing it.

How many tokens does Tooluniverse Polygenic Risk Score use?

About 3.7k tokens (SKILL.md is roughly 15k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Tooluniverse Polygenic Risk Score?

Skills that share tags, products or a category with Tooluniverse Polygenic Risk Score: Scanpy Single-Cell Analysis (davila7/claude-code-templates, 33k stars), Single-Cell Initial Analysis (LigphiDonk/Oh-my--paper, 739 stars), Ukb Ppp Region Fetch (ClawBio/ClawBio, 1.2k stars) and Gwas Pipeline (ClawBio/ClawBio, 1.2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Tooluniverse Polygenic Risk Score?

wu-yc (a GitHub user) maintains it in wu-yc/LabClaw, which has 1,055 GitHub stars. The repository holds 68 skills in this directory. The repository was last updated on March 19, 2026.

Source: wu-yc/LabClaw on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.