Agent skill

Systematic Review Guide

by wentorai in wentorai/research-plugins

Systematic review methodology with PRISMA and evidence synthesis

MITAuto-check passedResearch & Science

Install Systematic Review Guide

skills CLI
$ npx skills add wentorai/research-plugins --skill systematic-review-guide -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install wentorai/research-plugins systematic-review-guide --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/wentorai/research-plugins.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills/research/deep-research/systematic-review-guide .claude/skills/systematic-review-guide && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
systematic-review-guide
GitHub stars
298
Used in
1 other repo
Token cost
~2.1k tokens
SKILL.md length
480 words
Files
1
Skills in repo
405
Repo updated
First seen
Licence
MIT

At a glance

Systematic review methodology with PRISMA and evidence synthesis

  • Works in 8 steps: Define the Research Question → Register the Protocol → Conduct the Search → …
  • Tasks that involve Literature review
  • SKILL.md covers What Is a Systematic Review?, Step-by-Step Workflow and Common Pitfalls
  • Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md

What it does

Systematic Review Guide is an agent skill from wentorai/research-plugins. Systematic review methodology with PRISMA and evidence synthesis

Its SKILL.md is about 2.1k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.

It sits in Research & Science, covering Literature review and ORMs and data access. It works with Prisma. The repository describes itself as: 350+ academic research skills, MCP configs, and plugins for Research-Claw and AI agents. The licence is MIT.

When your agent uses it

  • Tasks that involve Literature review
  • Tasks that involve ORMs and data access

Example prompts

  • “/systematic-review-guide”

Requirements

  • Python 3

Workflow steps

8 steps, taken from the step headings in SKILL.md.

  1. Define the Research Question
  2. Register the Protocol
  3. Conduct the Search
  4. Screen Studies
  5. Extract Data
  6. Assess Risk of Bias
  7. Synthesize Evidence
  8. Report Using PRISMA 2020

What it can do on your machine

Read from SKILL.md and the folder at commit bf44b3c. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    No scripts in the folder and no shell commands in SKILL.md (its code samples are markdown, python and r).

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    No URLs in SKILL.md.

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Systematic Review Guide loads about 2.1k tokens when it runs. Until then it costs about 22 tokens; SKILL.md has 480 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~22
When it runs · the whole SKILL.md, loaded when a task matches
~2.1k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

The full file from wentorai/research-plugins at commit bf44b3c, republished under its MIT licence (© wentorai). 480 words, ~2,063 tokens.

Download SKILL.mdSave it as .claude/skills/systematic-review-guide/SKILL.md (or your agent's skills folder).
name
systematic-review-guide
description
Systematic review methodology with PRISMA and evidence synthesis

Systematic Review Guide

Conduct rigorous systematic reviews and meta-analyses following PRISMA 2020 guidelines, from protocol registration through evidence synthesis and reporting.

What Is a Systematic Review?

A systematic review is a structured, transparent, and reproducible method for identifying, evaluating, and synthesizing all relevant research on a specific question. Unlike narrative reviews, systematic reviews:

  • Follow a pre-registered protocol
  • Use comprehensive, documented search strategies
  • Apply explicit inclusion/exclusion criteria
  • Assess risk of bias in included studies
  • Synthesize findings quantitatively (meta-analysis) or narratively

Step-by-Step Workflow

Step 1: Define the Research Question

Use a structured framework to formulate your question:

FrameworkComponentsBest For
PICOPopulation, Intervention, Comparator, OutcomeClinical/intervention studies
PCCPopulation, Concept, ContextScoping reviews
SPIDERSample, Phenomenon of Interest, Design, Evaluation, Research typeQualitative/mixed methods
PEOPopulation, Exposure, OutcomeObservational studies

Example (PICO):

  • P: Adults with Type 2 diabetes
  • I: Telehealth-based self-management programs
  • C: Standard in-person care
  • O: HbA1c levels, quality of life
Step 2: Register the Protocol

Register your protocol before conducting the search to reduce publication bias and selective reporting:

  • PROSPERO (crd.york.ac.uk/prospero): Free registration for health-related systematic reviews
  • OSF Registries (osf.io/registries): Open to all disciplines
  • Protocol paper: Publish in BMJ Open, Systematic Reviews, or JMIR Research Protocols

Protocol should include:

  • Research question and objectives
  • Eligibility criteria
  • Search strategy (databases, search terms)
  • Screening process
  • Data extraction plan
  • Risk of bias assessment tool
  • Synthesis method (meta-analysis or narrative)
Recommended minimum databases (health sciences):
1. PubMed / MEDLINE
2. Embase
3. Cochrane Central Register of Controlled Trials (CENTRAL)
4. At least one subject-specific database

Recommended minimum databases (social sciences):
1. Web of Science
2. Scopus
3. PsycINFO or ERIC (field-specific)
4. ProQuest Dissertations (for grey literature)

Additional sources:
- Reference lists of included studies (backward citation chaining)
- Forward citation searches
- Grey literature: conference proceedings, theses, reports
- Trial registries: ClinicalTrials.gov, WHO ICTRP
- Preprint servers: medRxiv, SSRN

Document each search with: database name, date, exact search string, and number of results.

Step 4: Screen Studies

Two-stage screening, each conducted by at least two independent reviewers:

Stage 1: Title and Abstract Screening
- Apply inclusion/exclusion criteria based on title + abstract only
- Resolve disagreements by discussion or third reviewer
- Calculate inter-rater reliability (Cohen's kappa >= 0.60)

Stage 2: Full-Text Screening
- Retrieve full texts of all studies passing Stage 1
- Apply full eligibility criteria
- Document reasons for exclusion at this stage
- Calculate inter-rater reliability

Screening tools: Covidence (covidence.org), Rayyan (rayyan.ai), ASReview (AI-assisted)

Step 5: Extract Data

Create a standardized data extraction form:

markdown
| Field | Description |
|-------|-------------|
| Study ID | First author + year |
| Country | Where study was conducted |
| Study design | RCT, cohort, cross-sectional, etc. |
| Sample size | N in each group |
| Population | Demographics, inclusion criteria used |
| Intervention | Description, duration, intensity |
| Comparator | Description of control condition |
| Outcomes | Primary and secondary, measurement tools |
| Results | Effect sizes, confidence intervals, p-values |
| Funding | Source of funding |
| Conflicts of interest | Declared COIs |

Pilot the extraction form on 3-5 studies, then extract independently by two reviewers.

Show full SKILL.md (190 more words)Show less
Step 6: Assess Risk of Bias

Select the appropriate tool based on study design:

Study DesignToolDeveloper
Randomized trialsRoB 2Cochrane
Non-randomized interventionsROBINS-ICochrane
Observational (cohort, case-control)Newcastle-Ottawa Scale (NOS)Wells et al.
Cross-sectionalJBI Critical Appraisal ChecklistJoanna Briggs Institute
Qualitative studiesCASP Qualitative ChecklistCASP
Diagnostic accuracyQUADAS-2Whiting et al.
Step 7: Synthesize Evidence
Narrative Synthesis

When meta-analysis is not appropriate (due to heterogeneity in study designs, populations, or outcomes):

  1. Group studies by outcome, population, or intervention type
  2. Describe patterns and consistencies across studies
  3. Use vote counting only with direction of effect (not p-values)
  4. Present findings in summary tables
Meta-Analysis

When studies are sufficiently similar to pool quantitatively:

python
# Meta-analysis using Python (PythonMeta or custom)
# Example: Random-effects meta-analysis of standardized mean differences

import numpy as np
from scipy.stats import norm

def random_effects_meta(effects, variances):
    """DerSimonian-Laird random effects meta-analysis."""
    weights_fe = 1 / np.array(variances)
    theta_fe = np.sum(weights_fe * effects) / np.sum(weights_fe)

    # Estimate tau-squared (between-study variance)
    Q = np.sum(weights_fe * (effects - theta_fe)**2)
    df = len(effects) - 1
    C = np.sum(weights_fe) - np.sum(weights_fe**2) / np.sum(weights_fe)
    tau2 = max(0, (Q - df) / C)

    # Random effects weights
    weights_re = 1 / (np.array(variances) + tau2)
    theta_re = np.sum(weights_re * effects) / np.sum(weights_re)
    se_re = np.sqrt(1 / np.sum(weights_re))

    ci_lower = theta_re - 1.96 * se_re
    ci_upper = theta_re + 1.96 * se_re

    # Heterogeneity statistics
    I2 = max(0, (Q - df) / Q * 100) if Q > 0 else 0

    return {
        "pooled_effect": theta_re,
        "ci_lower": ci_lower,
        "ci_upper": ci_upper,
        "tau2": tau2,
        "I2": I2,
        "Q": Q,
        "p_heterogeneity": 1 - chi2.cdf(Q, df)
    }
r
# Meta-analysis in R using metafor
library(metafor)

# Random-effects model (REML estimator)
res <- rma(yi = effect_sizes, vi = variances, method = "REML", data = dat)
summary(res)

# Forest plot
forest(res, slab = dat$study_label, header = TRUE)

# Funnel plot (publication bias assessment)
funnel(res)

# Egger's test for funnel plot asymmetry
regtest(res)
Step 8: Report Using PRISMA 2020

The PRISMA 2020 flow diagram documents the study selection process:

Records identified from databases (n = X)
Records identified from other sources (n = X)
          |
Records after duplicates removed (n = X)
          |
Records screened (title/abstract) (n = X)
    -> Records excluded (n = X)
          |
Reports sought for retrieval (n = X)
    -> Reports not retrieved (n = X)
          |
Reports assessed for eligibility (n = X)
    -> Reports excluded with reasons (n = X)
       - Reason 1 (n = X)
       - Reason 2 (n = X)
       - Reason 3 (n = X)
          |
Studies included in review (n = X)
Studies included in meta-analysis (n = X)

Common Pitfalls

PitfallSolution
Incomplete searchSearch at least 3 databases + grey literature
Single reviewer screeningAlways use 2 independent reviewers
No protocol registrationRegister on PROSPERO or OSF before searching
Ignoring heterogeneityReport I-squared, conduct subgroup analyses
Publication bias unaddressedUse funnel plots, Egger's test, trim-and-fill
Selective outcome reportingExtract all pre-specified outcomes from protocol

© wentorai, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file

Files

Just SKILL.md in skills/research/deep-research/systematic-review-guide of wentorai/research-plugins.

Open the folder on GitHubat commit bf44b3c

Used in 1 other repository

We found 1 copy of this SKILL.md (exact, near-identical or edited) in other folders, from 1 other GitHub owner. This page covers the copy in wentorai/research-plugins, which our catalogue first saw on October 7, 2026.

Compare with similar skills

Systematic Review Guide next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

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Review PaperAperivue/medsci-skills333—~1.3kAutomated safety check: PassMIT
Deep Researchbrycewang-stanford/Auto-Empirical-Research-Skills4.6k—~8kAutomated safety check: PassCustom licence

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Works with

Questions about Systematic Review Guide

What does Systematic Review Guide do?

Systematic review methodology with PRISMA and evidence synthesis. Systematic Review Guide is an agent skill from wentorai/research-plugins.

When should I use Systematic Review Guide?

Systematic Review Guide fits situations like: tasks that involve Literature review; tasks that involve ORMs and data access.

How do I install Systematic Review Guide in Claude Code?

Run `npx skills add wentorai/research-plugins --skill systematic-review-guide -a claude-code`. Or copy the skill folder (skills/research/deep-research/systematic-review-guide in wentorai/research-plugins) into .claude/skills/systematic-review-guide in your project. Claude Code loads it when a task matches its description.

How do I install Systematic Review Guide in Codex?

Run `npx skills add wentorai/research-plugins --skill systematic-review-guide -a codex`. Or copy the skill folder (skills/research/deep-research/systematic-review-guide in wentorai/research-plugins) into .agents/skills/systematic-review-guide in your project. Codex loads it when a task matches its description.

Can I use Systematic Review Guide in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add wentorai/research-plugins --skill systematic-review-guide -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/systematic-review-guide, .gemini/skills/systematic-review-guide, .github/skills/systematic-review-guide and .opencode/skills/systematic-review-guide in your project.

What does Systematic Review Guide need to run?

SKILL.md names no scripts, command-line tools or credentials: Systematic Review Guide is instructions for the agent only. Our summary lists: Python 3.

Does Systematic Review Guide access the network?

SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.

Is Systematic Review Guide safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Systematic Review Guide use?

Systematic Review Guide is published under the MIT licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.

How many tokens does Systematic Review Guide use?

About 2.1k tokens (SKILL.md is roughly 8.3k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.

What are the alternatives to Systematic Review Guide?

Skills that share tags, products or a category with Systematic Review Guide: Lit Search (luwill/research-skills, 860 stars), Ma Search Bibliography (htlin222/meta-pipe, 139 stars), Meta Analysis (Aperivue/medsci-skills, 333 stars) and Review Paper (Aperivue/medsci-skills, 333 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Systematic Review Guide?

wentorai (a GitHub user) maintains it in wentorai/research-plugins, which has 298 GitHub stars. The repository holds 405 skills in this directory. The repository was last updated on June 19, 2026.

Source: wentorai/research-plugins on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.