Agent skill

Ngless

by ngless-toolkit in ngless-toolkit/ngless

Auto-activate when the user mentions NGLess, ngless, NGS processing, metagenomics pipelines with NGLess, writing .ngl scripts, or is working in the ngless repository (Rust source at src/).

Custom licenceAuto-check passedResearch & Science

Install Ngless

skills CLI
$ npx skills add ngless-toolkit/ngless --skill ngless -a claude-code

Project install by default; add -g for ~/.claude/skills/.

GitHub CLI
$ gh skill install ngless-toolkit/ngless ngless --agent claude-code

Project scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).

Manual copy
$ git clone --depth 1 https://github.com/ngless-toolkit/ngless.git skills-src && mkdir -p .claude/skills && cp -r skills-src/skills .claude/skills/ngless && rm -rf skills-src

Use ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.

Claude Code skills documentation · loads skills from .claude/skills/

Facts

Skill name
ngless
GitHub stars
152
Token cost
~7k tokens
SKILL.md length
2,640 words
Files
3 (incl. references)
Skills in repo
1
Repo updated
First seen
Licence
Custom licence

At a glance

Auto-activate when the user mentions NGLess, ngless, NGS processing, metagenomics pipelines with NGLess, writing .ngl scripts, or is working in the ngless repository (Rust source at src/).

  • Works in 12 steps: Indexing a function call's result is not… → Wrong version declaration: the first… → Old module import versions: import… → …
  • Mentions NGLess
  • SKILL.md covers Script Structure, Data Types, Builtin Functions and Modules, plus 4 more sections
  • Calls conda

What it does

Ngless is an agent skill from ngless-toolkit/ngless. Auto-activate when the user mentions NGLess, ngless, NGS processing, metagenomics pipelines with NGLess, writing .ngl scripts, or is working in the ngless repository (Rust source at src/). Also activate when the user asks about preprocessing FASTQ reads, mapping reads to references, counting features, or parallel sample processing in the context of NGLess scripting or development.

Its SKILL.md is about 7k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files, including reference files (for example `references/configuration-and-paths.md` and `references/developer-guide.md`).

It sits in Research & Science, covering Bioinformatics. It works with Rust. The repository describes itself as: NGLess: NGS with less work.

When your agent uses it

  • Mentions NGLess
  • Metagenomics pipelines with NGLess
  • Writing .ngl scripts
  • Is working in the ngless repository (Rust source at src/)

Example prompts

  • “/ngless”

Requirements

  • Python 3

Workflow steps

12 steps, taken from the first numbered list in SKILL.md.

  1. Indexing a function call's result is not supported: use xs = readlines(f) then xs[0],
  2. Wrong version declaration: the first non-comment line must be ngless "1.6". ngless "1.5" (and
  3. Old module import versions: import "parallel" version "1.1" still works but warns; use "1.6".
  4. Using tabs: only spaces allowed (4-space indent)
  5. Forgetting discard: in preprocess blocks, filtered reads must be explicitly discarded with discard
  6. select symbols confusion: keep_if=[{mapped}] keeps mapped reads; drop_if=[{mapped}] removes them.
  7. count annotation sources: if features != ['seqname'], you need exactly one of gff_file=,
  8. strand= on count(): removed; use sense={sense}
  9. Spaces in a functional_map TSV are part of the feature name: a, b means a and b
  10. load_fastq_directory is picky about names: .fq/.fastq (after any .gz/.bz2/.xz),
  11. Relative paths in a YAML sample list resolve against basedir, or else the current working
  12. Parallel scripts: must run multiple NGLess processes (one per sample) — the parallel module

What it can do on your machine

Read from SKILL.md and the folder at commit cb476d2. It shows what the files ask for, not the result of running them.

  • Tool permissions

    Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.

    From allowed-tools in the SKILL.md frontmatter.

  • Runs code

    Shell commands in SKILL.md call:

    • conda

    From the folder's file list and the shell code blocks in SKILL.md.

  • Network

    Links to these hosts (documentation or services it may open):

    • eggnog-mapper.embl.de
    • pixi.sh

    From URLs in SKILL.md, links to its own repository left out.

  • Credentials

    Names no API keys, tokens, secrets or passwords.

    From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.

Context cost

Ngless loads about 7k tokens when it runs, and up to ~13k if it reads all its reference files. Until then it costs about 98 tokens; SKILL.md has 2,640 words of instructions outside code blocks.

Always · name and description, kept in context so the agent knows when to use it
~98
When it runs · the whole SKILL.md, loaded when a task matches
~7k
With references · SKILL.md plus every file in references/, read only if the agent opens them
~13k

Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.

Safety

Auto-check passed

The automated check found no risky patterns in SKILL.md.

Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.

SKILL.md

Its licence (Custom licence) doesn't allow us to republish the file, so here is its outline and opening line. It has 2,640 words (~6,993 tokens).

“NGLess is a domain-specific language (DSL) for next-generation sequencing (NGS) data processing, with a focus on metagenomics. It has a Pythonesque syntax with Ruby-like blocks, is statically typed with type inference, and emphasizes reproducibility and error checking.”

— opening of SKILL.md by ngless-toolkit, Custom licence
name
ngless
version
1.0.0

Read the full SKILL.md on GitHub

Files

SKILL.md and 2 other files (references) in skills of ngless-toolkit/ngless.

  • SKILL.md
  • references/configuration-and-paths.md
  • references/developer-guide.md

Open the folder on GitHubat commit cb476d2

Compare with similar skills

Ngless next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.

Ngless compared with similar skills
SkillStarsUsed inTokensAuto-checkLicenceRepo updated
Ngless this skillngless-toolkit/ngless152—~7kAutomated safety check: PassCustom licence
Gtars Genomic Interval Toolkitdavila7/claude-code-templates32k12 repos~1.9kAutomated safety check: PassMIT
GtarsK-Dense-AI/scientific-agent-skills48k1 repos~3.8kAutomated safety check: NotesMIT
Gtarsaipoch/medical-research-skills2k—~1.1kAutomated safety check: PassMIT
Gtarsjaechang-hits/SciAgent-Skills370—~4.2kAutomated safety check: PassMIT
Alphagenome Single Variant Analysisgoogle-deepmind/science-skills3.2k2 repos~3kAutomated safety check: NotesApache-2.0

Similar skills

  • Gtars Genomic Interval Toolkit

    davila7/claude-code-templates

    Works with genomic intervals using gtars, a Rust toolkit with Python bindings: overlap detection, coverage tracks, tokenization for ML models and reference sequences.

    32k GitHub starsUsed in 12 repos~1.9k tokens
    Research & ScienceAuto-check passed
  • Gtars

    K-Dense-AI/scientific-agent-skills

    Supports Gtars for local genomic interval models and set algebra, overlaps and counts, consensus and coverage, tokenization, fragment processing, and refget/BEDbase planning across Python, Rust, and…

    48k GitHub starsUsed in 1 repo~3.8k tokens
    Research & ScienceAuto-check: notes
  • Gtars

    aipoch/medical-research-skills

    A high-performance Rust toolkit (with Python bindings and a CLI) for genomic interval analysis; use it when you need fast overlap queries, coverage track generation, genomic tokenization for ML…

    2k GitHub stars~1.1k tokensUpdated 20 days ago
    Research & ScienceAuto-check passed
  • Gtars

    jaechang-hits/SciAgent-Skills

    Rust-backed Python library for fast genomic token arithmetic and BED processing.

    370 GitHub stars~4.2k tokensUpdated 8 days ago
    Research & ScienceAuto-check passed
  • Alphagenome Single Variant Analysis

    google-deepmind/science-skills

    Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API.

    3.2k GitHub starsUsed in 2 repos~3k tokens
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  • 13C Metabolic Flux Analysis

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Works with

Questions about Ngless

What does Ngless do?

Auto-activate when the user mentions NGLess, ngless, NGS processing, metagenomics pipelines with NGLess, writing .ngl scripts, or is working in the ngless repository (Rust source at src/). Ngless is an agent skill from ngless-toolkit/ngless.ngl scripts, or is working in the ngless repository (Rust source at src/).

When should I use Ngless?

Ngless fits situations like: mentions NGLess; metagenomics pipelines with NGLess; writing .ngl scripts; is working in the ngless repository (Rust source at src/).

How do I install Ngless in Claude Code?

Run `npx skills add ngless-toolkit/ngless --skill ngless -a claude-code`. Or copy the skill folder (skills in ngless-toolkit/ngless) into .claude/skills/ngless in your project. Claude Code loads it when a task matches its description.

How do I install Ngless in Codex?

Run `npx skills add ngless-toolkit/ngless --skill ngless -a codex`. Or copy the skill folder (skills in ngless-toolkit/ngless) into .agents/skills/ngless in your project. Codex loads it when a task matches its description.

Can I use Ngless in Cursor, Gemini CLI or GitHub Copilot?

Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add ngless-toolkit/ngless --skill ngless -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/ngless, .gemini/skills/ngless, .github/skills/ngless and .opencode/skills/ngless in your project.

What does Ngless need to run?

Going by SKILL.md and its folder, Ngless needs the command-line tools its instructions call (conda). Our summary lists: Python 3.

Does Ngless access the network?

SKILL.md names 2 domains. As links in the text: eggnog-mapper.embl.de and pixi.sh. This is read from the text; nothing was executed.

Is Ngless safe to install?

Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.

What licence does Ngless use?

Ngless has a licence file (the repository's licence) that doesn't match a standard licence. Read it on GitHub before reusing the skill.

How many tokens does Ngless use?

About 7k tokens (SKILL.md is roughly 28k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full. Its references folder adds about 6.2k tokens, read only when the agent opens those files.

What are the alternatives to Ngless?

Skills that share tags, products or a category with Ngless: Gtars Genomic Interval Toolkit (davila7/claude-code-templates, 32k stars), Gtars (K-Dense-AI/scientific-agent-skills, 48k stars), Gtars (aipoch/medical-research-skills, 2k stars) and Gtars (jaechang-hits/SciAgent-Skills, 370 stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.

Who maintains Ngless?

ngless-toolkit (a GitHub organization) maintains it in ngless-toolkit/ngless, which has 152 GitHub stars. The repository was last updated on October 1, 2026.

Source: ngless-toolkit/ngless on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.