Hypothesis Generation
spacering-net/codeg
Structured hypothesis formulation from observations. An agent skill from spacering-net/codeg.
How to organise a session run so a human can audit it — directory layout, artifact naming, recording the analysis plan, filing claim-evidence objects, and the end-of-run checklist.
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organization --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .claude/skills && cp -r skills-src/.claude/skills/run-organization .claude/skills/run-organization && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .claude/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organizationType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organization --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .agents/skills && cp -r skills-src/.claude/skills/run-organization .agents/skills/run-organization && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .agents/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organization --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/.claude/skills/run-organization .cursor/skills/run-organization && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .cursor/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/harrisongzhang/TheVirtualBiotech.git --path .claude/skills/run-organization--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organization --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/.claude/skills/run-organization .gemini/skills/run-organization && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .gemini/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organizationInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .github/skills && cp -r skills-src/.claude/skills/run-organization .github/skills/run-organization && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .github/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install harrisongzhang/TheVirtualBiotech run-organization --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/harrisongzhang/TheVirtualBiotech.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/.claude/skills/run-organization .opencode/skills/run-organization && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "run-organization" agent skill from https://github.com/harrisongzhang/TheVirtualBiotech/tree/main/.claude/skills/run-organization into .opencode/skills/run-organization/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "run-organization", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
run-organizationHow to organise a session run so a human can audit it — directory layout, artifact naming, recording the analysis plan, filing claim-evidence objects, and the end-of-run checklist.
Run Organization is an agent skill from harrisongzhang/TheVirtualBiotech. How to organise a session run so a human can audit it — directory layout, artifact naming, recording the analysis plan, filing claim-evidence objects, and the end-of-run checklist. Use when orchestrating specialists (the CSO role), whenever you are about to dispatch work or synthesise findings, or when you need to know where an artifact belongs.
Its SKILL.md is about 1.8k tokens, which your agent loads only when the skill is triggered. It is a single SKILL.md file with no bundled scripts.
It sits in Research & Science. The repository describes itself as: Multi-agent AI system for drug-target identification and due diligence. The licence is MIT.
4 steps, taken from the step headings in SKILL.md.
Read from SKILL.md and the folder at commit 71f9da6. It shows what the files ask for, not the result of running them.
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
No scripts in the folder and no shell commands in SKILL.md (its code samples are python).
From the folder's file list and the shell code blocks in SKILL.md.
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Run Organization loads about 1.8k tokens when it runs. Until then it costs about 91 tokens; SKILL.md has 710 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
The full file from harrisongzhang/TheVirtualBiotech at commit 71f9da6, republished under its MIT licence (© harrisongzhang). 710 words, ~1,799 tokens.
.claude/skills/run-organization/SKILL.md (or your agent's skills folder).A reviewer ran the system, got a pile of files, and could not tell how they were organised, which artifact supported which claim from which specialist, or how the analysis flowed together. They also could not replay it.
That is a fair description of what an unmanaged run produces. This skill is the standard that prevents it. The rule behind every instruction here:
Every run must be understandable by someone who was not there, opening the directory cold, six months later.
Every session gets one directory. You are working inside it now.
runs/<RUN_ID>/
├── MANIFEST.json every artifact: hash, producing agent, producing tool call
├── README.md generated map of the run — do not hand-edit
├── audit.html self-contained report for someone with no environment
├── inputs/
│ ├── query.txt the user's turns, verbatim
│ ├── plan.json the analysis DAG you declared ← you write this
│ └── config.json models, prompt hashes, MCP servers, git commit
├── work/<agent>/ one subtree per specialist — never flat
│ ├── code/scripts/
│ ├── data/{raw,processed}/
│ └── results/{figures,tables,reports}/
├── evidence/
│ ├── claims.json claim → evidence ← you write this
│ └── provenance.json tool call → agent, derived from the trace
├── logs/ trace.jsonl, cost_report.json, transcript.md
└── report/FINAL_REPORT.mdMANIFEST.json, provenance.json, README.md and audit.html are generated.
Your two responsibilities are plan.json and claims.json.
Before dispatching two or more specialists, call mcp__provenance__write_plan.
write_plan(
goal="Assess the safety risk of targeting IL-33 in asthma",
steps=[
{"id": "s1", "agent": "single-cell-analyst",
"task": "IL33/IL1RL1 expression across lung and critical-organ cell types",
"depends_on": [], "expected_outputs": ["il33_celltype_expression.csv"]},
{"id": "s2", "agent": "fda-safety-officer",
"task": "Clinical precedent AEs read against the expression profile",
"depends_on": ["s1"]},
])depends_on: [] → can start immediately. Steps that do not depend on each
other are dispatched in parallel.depends_on only for real data dependencies. Over-declaring
serialises work that could have run concurrently and makes the run slower for
no auditing benefit.write_plan again with the revised plan.Each specialist writes only under work/<its-own-name>/. Its prompt tells it so,
and the system records anything written elsewhere and attributes it anyway — but a
file in the wrong place is still a file the next reader has to puzzle over.
When you delegate, if a specialist needs an earlier one's output, give it the path:
Load the expression table from
work/single-cell-analyst/results/tables/il33_celltype_expression.csvDo not tell a specialist to "check the workspace" and hope. Name the file.
Name for content, never for sequence or status.
| Good | Bad | Why |
|---|---|---|
il33_celltype_expression.csv | analysis2.csv | says what is in it |
gwas_credible_sets_chr9.parquet | cs_2fd0.parquet | readable six months later |
safety_ae_summary.md | results_final_v3.md | "final v3" tells a reader nothing |
If you find yourself appending _v2, the first file was either superseded (say
so in its description) or the two differ in a way the name should state.
Every substantive factual assertion in your synthesis becomes a claim with the
evidence behind it. See the evidence-citation skill for the specialist-side
contract that produces citable artifacts in the first place.
Sequence:
mcp__provenance__list_artifacts — get the exact paths. Do not guess a
filename; a path that does not exist is rejected....highly expressed in lung mast cells[[claim:C1]]...mcp__provenance__record_claims with the claim objects.record_claims(claims=[
{"id": "C1",
"text": "IL1RL1 is most highly expressed in lung mast cells (mean 2.4 CPM)",
"agent": "single-cell-analyst",
"confidence": "strong",
"evidence": [
{"kind": "table",
"path": "work/single-cell-analyst/results/tables/il33_celltype_expression.csv",
"note": "row: mast cell"},
{"kind": "figure",
"path": "work/single-cell-analyst/results/figures/il33_celltype.png"}]}])Rules that matter:
ok: false means a path or tool id is wrong —
fix it and call again.confidence: strong = direct measurement; moderate = inference;
weak = suggestive or indirect.[[claim:Cn]] anchor must correspond to a filed claim. A dangling anchor
renders as a visibly broken marker and is reported as a defect in the README.Before your final response:
write_plan called, if two or more specialists ran[[claim:Cn]] anchorrecord_claims returned ok: true for all of themlist_artifacts shows no unexplained files — anything a specialist produced
that carries a finding should have a descriptionFiling a claim with weak evidence to clear the checklist. The confidence
field exists so you can be honest. weak with a real artifact beats strong
with a stretched one.
Citing a specialist's prose. If a specialist asserted a number but wrote no file, there is nothing to cite. Report it as an unsupported statement, or send the specialist back to produce the artifact.
One claim covering a whole paragraph. One claim = one checkable assertion. If the text spans three findings from two specialists, that is three claims.
Silently dropping a failed analysis. A specialist that timed out or returned nothing is part of the run's story. Say so, and adjust your confidence.
© harrisongzhang, MIT. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file
Just SKILL.md in .claude/skills/run-organization of harrisongzhang/TheVirtualBiotech.
Open the folder on GitHubat commit 71f9da6
Run Organization next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Run Organization this skillharrisongzhang/TheVirtualBiotech | 122 | — | ~1.8k | Automated safety check: Pass | MIT | |
| Hypothesis Generationspacering-net/codeg | 3.9k | 14 repos | ~3.6k | Automated safety check: Notes | MIT | |
| GitHub Deep Researchbytedance/deer-flow | 84k | 4 repos | ~1.3k | Automated safety check: Pass | MIT | |
| Nature Paper CardYuan1z0825/nature-skills | 47k | 2 repos | ~2.1k | Automated safety check: Pass | Apache-2.0 | |
| Content Research Writerweapp-tailwindcss/weapp-tailwindcss | 1.9k | 25 repos | ~3.5k | Automated safety check: Pass | MIT | |
| Last30daysmvanhorn/last30days-skill | 64k | — | ~7.9k | Automated safety check: Notes | MIT |
spacering-net/codeg
Structured hypothesis formulation from observations. An agent skill from spacering-net/codeg.
bytedance/deer-flow
Researches a GitHub repository over four rounds using the GitHub API and web search, then writes a structured markdown report with timeline, metrics and Mermaid diagrams.
Yuan1z0825/nature-skills
Builds a structured deep-reading card for one scientific paper, covering methods, how experiments support claims, limitations and research ideas, with a script to prepare the source.
weapp-tailwindcss/weapp-tailwindcss
Assists in writing high-quality content by conducting research, adding citations, improving hooks, iterating on outlines, and providing real-time feedback on each section.
mvanhorn/last30days-skill
Research what people actually say about any topic in the last 30 days.
spacering-net/codeg
Structured manuscript/grant review with checklist-based evaluation.
harrisongzhang/TheVirtualBiotech
How to report findings so they can be cited — writing evidence to files before asserting it, choosing where outputs belong, describing what each artifact shows, and returning findings with…
harrisongzhang/TheVirtualBiotech
Statistical analysis and reporting for single-cell RNA-seq data.
harrisongzhang/TheVirtualBiotech
Single-cell RNA-seq data preparation and quality control pipeline.
Categories
How to organise a session run so a human can audit it — directory layout, artifact naming, recording the analysis plan, filing claim-evidence objects, and the end-of-run checklist. Run Organization is an agent skill from harrisongzhang/TheVirtualBiotech. How to organise a session run so a human can audit it — directory layout, artifact naming, recording the analysis plan, filing claim-evidence objects, and the end-of-run checklist.
Run Organization fits situations like: orchestrating specialists (the CSO role); whenever you are about to dispatch work; synthesise findings; you need to know where an artifact belongs.
Run `npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a claude-code`. Or copy the skill folder (.claude/skills/run-organization in harrisongzhang/TheVirtualBiotech) into .claude/skills/run-organization in your project. Claude Code loads it when a task matches its description.
Run `npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a codex`. Or copy the skill folder (.claude/skills/run-organization in harrisongzhang/TheVirtualBiotech) into .agents/skills/run-organization in your project. Codex loads it when a task matches its description.
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add harrisongzhang/TheVirtualBiotech --skill run-organization -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/run-organization, .gemini/skills/run-organization, .github/skills/run-organization and .opencode/skills/run-organization in your project.
SKILL.md names no scripts, command-line tools or credentials: Run Organization is instructions for the agent only. Our summary lists: Python 3.
SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
Run Organization is published under the MIT licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.
About 1.8k tokens (SKILL.md is roughly 7.2k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full.
Skills that share tags, products or a category with Run Organization: Hypothesis Generation (spacering-net/codeg, 3.9k stars), GitHub Deep Research (bytedance/deer-flow, 84k stars), Nature Paper Card (Yuan1z0825/nature-skills, 47k stars) and Content Research Writer (weapp-tailwindcss/weapp-tailwindcss, 1.9k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
harrisongzhang (a GitHub user) maintains it in harrisongzhang/TheVirtualBiotech, which has 122 GitHub stars. The repository holds 4 skills in this directory. The repository was last updated on September 17, 2026.
Source: harrisongzhang/TheVirtualBiotech on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.