Searching Clinicaltrials
maziyarpanahi/openmed
Searches ClinicalTrials.gov for studies by condition, intervention, and recruitment status using the modern v2 REST API with cursor (pageToken) pagination.
Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03).
Install Ct Status Diff
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a claude-codeProject install by default; add -g for ~/.claude/skills/.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diff --agent claude-codeProject scope by default; add --scope user for a personal install. Needs GitHub CLI 2.90.0 or later (public preview).
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .claude/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .claude/skills/ct-status-diff && rm -rf skills-srcUse ~/.claude/skills/ instead of .claude/skills for a personal install. The folder must contain SKILL.md.
Claude Code skills documentation · loads skills from .claude/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .claude/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.Claude Code copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$skill-installer install https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diffType this inside Codex. $skill-installer <name> installs a curated skill from openai/skills. The installer writes to $CODEX_HOME/skills (default ~/.codex/skills). Restart Codex if the skill does not show up.
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a codexProject install goes to .agents/skills/; add -g for ~/.codex/skills/.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diff --agent codexProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .agents/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .agents/skills/ct-status-diff && rm -rf skills-srcUse ~/.agents/skills/ instead of .agents/skills for a personal install.
Codex skills documentation · loads skills from .agents/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .agents/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.Codex copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a cursorProject install goes to .agents/skills/; add -g for ~/.cursor/skills/.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diff --agent cursorProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .cursor/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .cursor/skills/ct-status-diff && rm -rf skills-srcUse ~/.cursor/skills/ instead of .cursor/skills for a personal install.
Cursor skills documentation · loads skills from .cursor/skills/, .agents/skills/, .claude/skills/, .codex/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .cursor/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.Cursor copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gemini skills install https://github.com/agentii-ai/agentii-investment-intelligence.git --path plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff--scope user (default) or --scope workspace; --path is the subfolder of the repo that holds the skill; --consent skips the security confirmation prompt.
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a gemini-cliProject install goes to .agents/skills/; add -g for ~/.gemini/skills/.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diff --agent gemini-cliProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .gemini/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .gemini/skills/ct-status-diff && rm -rf skills-srcUse ~/.gemini/skills/ instead of .gemini/skills for a personal install, then run /skills reload.
Gemini CLI skills documentation · loads skills from .gemini/skills/, .agents/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .gemini/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.Gemini CLI copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diffInstalls for Copilot at project scope by default; add --scope user for a personal install. Preview a skill first with gh skill preview. Needs GitHub CLI 2.90.0 or later (public preview).
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a github-copilotProject install goes to .agents/skills/; add -g for ~/.copilot/skills/.
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .github/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .github/skills/ct-status-diff && rm -rf skills-srcUse ~/.copilot/skills/ instead of .github/skills for a personal install. Commit .github/skills so cloud agent and code review can use it.
GitHub Copilot skills documentation · loads skills from .github/skills/, .claude/skills/, .agents/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .github/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.GitHub Copilot copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
$ npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a opencodeOpenCode documents no install command of its own. Project install goes to .agents/skills/; add -g for ~/.config/opencode/skills/.
$ gh skill install agentii-ai/agentii-investment-intelligence ct-status-diff --agent opencodeProject scope by default (.agents/skills/); add --scope user for a personal install.
$ git clone --depth 1 https://github.com/agentii-ai/agentii-investment-intelligence.git skills-src && mkdir -p .opencode/skills && cp -r skills-src/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff .opencode/skills/ct-status-diff && rm -rf skills-srcUse ~/.config/opencode/skills/ instead of .opencode/skills for a personal install.
OpenCode skills documentation · loads skills from .opencode/skills/, .claude/skills/, .agents/skills/
Install the "ct-status-diff" agent skill from https://github.com/agentii-ai/agentii-investment-intelligence/tree/main/plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff into .opencode/skills/ct-status-diff/ in this project. Copy the whole folder (SKILL.md and every file beside it), keep the folder name "ct-status-diff", then confirm the skill loads.OpenCode copies the folder itself, the same result as the manual copy. Check what it changed before you commit it.
Facts
- Skill name
ct-status-diff- GitHub stars
- 207
- Token cost
- ~1.8k tokens
- SKILL.md length
- 688 words
- Files
- 3 (incl. references)
- Skills in repo
- 79
- Repo updated
- First seen
- Licence
- Apache-2.0
At a glance
Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03).
- Works in 5 steps: get_ct_status_changes — the… → Trial context: search_clinical_trials /… → Company context: search_companies /… → …
- Tasks that involve Recruiting and HR
- SKILL.md covers Defaults, Preflight, Triggers and Production Grounding, plus 11 more sections
- Instructions only: no scripts, shell commands, URLs or credentials in SKILL.md
What it does
Ct Status Diff is an agent skill from agentii-ai/agentii-investment-intelligence. Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized, every row carrying previous and new values, with risk flags on Terminated and Downsized and re-timing flags on Ahead and Delayed. The stored-previous-value discipline makes each week's diff…
Its SKILL.md is about 1.8k tokens, which your agent loads only when the skill is triggered. The skill folder holds 3 other files, including reference files (for example `references/knowledge-frameworks.md` and `references/modes.md`).
It sits in Business, Finance & HR, covering Recruiting and HR and Clinical and healthcare research. The repository describes itself as: Claude-type skills for institutional equity research — 25 AI agent skills with SEC filings, XBRL financials, earnings calendars, DCF/comps/LBO models, and PPT generation. Powered… The licence is Apache-2.0.
When your agent uses it
- Tasks that involve Recruiting and HR
- Tasks that involve Clinical and healthcare research
Example prompts
- “/ct-status-diff”
Workflow steps
5 steps, taken from the first numbered list in SKILL.md.
- get_ct_status_changes — the stored-weekly-snapshot diff (pipeline.ct_status_snapshot).
- Trial context: search_clinical_trials / get_clinical_trial for design and endpoints.
- Company context: search_companies / get_company_profile.
- Historical grounding: search_investment_cases (event_type=termination/delay/safety) + search_by_analogue.
- Knowledge: search_knowledge_entries for trial-judgment patterns.
What it can do on your machine
Read from SKILL.md and the folder at commit 86980e1. It shows what the files ask for, not the result of running them.
Tool permissions
Pre-approves nothing: there is no allowed-tools line, so your agent's usual permission prompts apply.
From allowed-tools in the SKILL.md frontmatter.
Runs code
No scripts in the folder and no shell commands in SKILL.md.
From the folder's file list and the shell code blocks in SKILL.md.
Network
No URLs in SKILL.md.
From URLs in SKILL.md, links to its own repository left out.
Credentials
Names no API keys, tokens, secrets or passwords.
From names ending in _API_KEY, _TOKEN, _SECRET, _KEY or _PASSWORD in SKILL.md.
Context cost
Ct Status Diff loads about 1.8k tokens when it runs, and up to ~2.5k if it reads all its reference files. Until then it costs about 134 tokens; SKILL.md has 688 words of instructions outside code blocks.
Estimates: characters ÷ 4, the usual rule of thumb; real counts depend on the model's tokenizer. Scripts and assets cost tokens only if the agent reads them.
Safety
Auto-check passed
The automated check found no risky patterns in SKILL.md.
Automated static check — not a guarantee. Review scripts before installing. It scans the text of SKILL.md for risky patterns (piping downloads into a shell, reading credential files, hidden Unicode, destructive commands); files beside SKILL.md are not scanned.
SKILL.md
The full file from agentii-ai/agentii-investment-intelligence at commit 86980e1, republished under its Apache-2.0 licence (© agentii-ai). 688 words, ~1,795 tokens.
Download SKILL.mdSave it as
.claude/skills/ct-status-diff/SKILL.md (or your agent's skills folder). This skill also uses 2 other files; get the full folder from GitHub.- name
- ct-status-diff
- description
- Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized, every row carrying previous and new values, with risk flags on Terminated and Downsized and re-timing flags on Ahead and Delayed. The stored-previous-value discipline makes each week's diff reproducible.
- sectors
- med.medicines_biotech, med.medical_devices
- multi_ticker_semantics
- basket_v1_1
- temporal_scope.default_quarters
- 4
- temporal_scope.max_quarters
- 8
- temporal_scope.description
- Weekly diff over the latest two snapshots by default; up to 8 quarters of diff history on request.
- retrieval_scope
- structured_only
- min_tool_diversity
- 3
- parameter_free
- false
Methodology inspired by publicly taught clinical-trial monitoring frameworks; all text is an original paraphrase.
Defaults
| Parameter | Default Value | Rationale |
|---|---|---|
| window | latest two snapshots | The diff is always between consecutive stored states |
| categories | all 11 | Complete change report; filter on request |
| risk_flags | on | Terminated / Downsized are surfaced first |
| gap_statement | on | Missing snapshot weeks are stated, never inferred |
Preflight
Run canonical pre-flight per contracts/preflight.md. Include the X-Agentii-Trace header on every tool call per contracts/x-agentii-trace-header.md — carry the _run_id from your first tool result and name yourself (and your parent, if you were spawned). Confirm the snapshot coverage via get_ct_status_changes before framing any readout.
Triggers
- "What changed on clinicaltrials.gov for my coverage this week?"
- "Which of [ticker]'s trials moved this week?"
- "Any trial delays or accelerations in my watchlist?"
- "Flag every terminated or downsized trial since last week."
- "Did any recruitment complete for [ticker]?"
- "Show the previous and new primary-completion dates for [drug]'s program."
- "Which trials were upsized this week?"
- "Is [trial]'s enrollment collapsing?"
- "Summarize the week's trial-registry changes for the sector."
- "What should I re-check ahead of [readout] based on registry moves?"
- "Compare this week's diff to the month-ago diff."
Production Grounding
- The diff is a stored-state comparison: every row pairs a NEW value with the PREVIOUS value from the prior snapshot — the previous-value column is the discipline; a row without both is a defect.
- The 11-category taxonomy: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized.
- Risk signals: Terminated and Downsized (enrollment collapse is the earliest visible distress). Re-timing alerts: Ahead / Delayed primary-completion moves.
- Recruitment-Complete means the readout clock has started — treat it as a catalyst-date confirmation.
- Gap windows: if snapshots are not consecutive archive writes, the gap is stated on the rows — a change is never attributed across a missing week.
- Determinism: identical snapshots yield byte-identical diffs; never invent an intermediate state.
- Badge discipline:
[FACT]registry rows,[DEDUCTED]interpretations,[VIEW]positioning, with the summary table.
Data Source Priority
get_ct_status_changes— the stored-weekly-snapshot diff (pipeline.ct_status_snapshot).- Trial context:
search_clinical_trials/get_clinical_trialfor design and endpoints. - Company context:
search_companies/get_company_profile. - Historical grounding:
search_investment_cases(event_type=termination/delay/safety) +search_by_analogue. - Knowledge:
search_knowledge_entriesfor trial-judgment patterns.
Methodology
Retrieval Scope
structured_only
Retrieval Strategy
- Pull the weekly diff via
get_ct_status_changes(ticker-filtered for single names, sector-wide for watchlists). - Rank rows: risk signals first, then re-timing, then recruiting/completed, then new.
- For each risk-signal row, pull the trial's design via
get_clinical_trialand state what changed and what it implies. - Ground termination/delay reads in
search_investment_cases/search_by_analogue(sectors=med); cite /v/ records. - Attach the gap-window statement verbatim wherever the tool reports one.
Show full SKILL.md (264 more words)Show less
Temporal Scope
See frontmatter temporal_scope block. Historical diff series (month-over-month) available on request.
Tool Allowlist
See frontmatter allowed_tools.
Protocol
- Snapshot-diff pull
- Risk/re-timing triage
- Per-signal trial context
- Historical grounding
- Weekly change report + watch flags
Modes
- Watchlist (default): one diff report across the basket, sorted risk-first.
- Single ticker: per-trial change ledger with trial context.
- Signal scan: restrict to risk signals (Terminated/Downsized) or re-timing (Ahead/Delayed).
Tool Fallbacks
| Failure | Fallback |
|---|---|
| get_ct_status_changes empty (<2 snapshots) | State the coverage gap: the diff needs two consecutive snapshot cycles; use search_clinical_trials metadata as a degraded view |
| Trial not in snapshots | Flag as registry-coverage gap; do not fabricate a previous value |
| Knowledge tools empty | Proceed with structured diff only; annotate knowledge coverage_gap |
Output File
{ticker}/{YYYY-MM-DD_HHMM}_ct-status-diff_{affix}.md (watchlist: watchlist/{YYYY-MM-DD_HHMM}_ct-status-diff_{affix}.md)
Output Structure
- Executive Summary — the week in trial-registry changes, 2-3 sentences
- Risk Signals — Terminated / Downsized rows with previous/new values and trial context
- Re-Timing Alerts — Ahead / Delayed rows with date deltas
- Flow Changes — New / Recruiting / Recruitment-Complete / Completed / Suspended / Withdrawn rows
- Gap Statement — snapshot windows with missing weeks stated
- Watch Flags — what to re-check before the next readout
- Coverage Gaps — missing snapshots, unregistered trials, degraded modes
Error Handling
| Error | Fallback |
|---|---|
| Fewer than 2 snapshots | coverage_gap with the two-cycle requirement; degraded metadata view only |
| Empty diff | State it plainly — a clean week is a valid result; never pad |
| Ticker not in med universe | Resolve via company match; surface the classification gap |
Memory Load
See contracts/memory-load.md.
Snapshot
See contracts/snapshot-synthesis.md.
Final Summary (TUI)
Include ### Key Citations block with 0-10 clickable /v/ URLs.
References
contracts/citation-and-memory.mdcontracts/output-frontmatter-schema.mdcontracts/memory-load.mdcontracts/snapshot-synthesis.mdcontracts/preflight.mdreferences/knowledge-frameworks.md
© agentii-ai, Apache-2.0. Rendered from Markdown: HTML in the file is shown as text, images as links, and headings moved down two levels. Raw file
Files
SKILL.md and 2 other files (references) in plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff of agentii-ai/agentii-investment-intelligence.
- SKILL.md
- references/knowledge-frameworks.md
- references/modes.md
Open the folder on GitHubat commit 86980e1
Compare with similar skills
Ct Status Diff next to the 5 skills that share the most tags, products or categories with it. Stars are the repository's; “used in” counts other GitHub owners with a copy.
| Skill | Stars | Used in | Tokens | Auto-check | Licence | Repo updated |
|---|---|---|---|---|---|---|
| Ct Status Diff this skillagentii-ai/agentii-investment-intelligence | 207 | — | ~1.8k | Automated safety check: Pass | Apache-2.0 | |
| Searching Clinicaltrialsmaziyarpanahi/openmed | 5.5k | — | ~2k | Automated safety check: Pass | Apache-2.0 | |
| Clinicaltrials DBaipoch/medical-research-skills | 2k | — | ~762 | Automated safety check: Pass | MIT | |
| Clinical Trials Databasegoogle-deepmind/science-skills | 3.2k | 3 repos | ~3.2k | Automated safety check: Pass | Apache-2.0 | |
| Inclusion Criteria Genaipoch/medical-research-skills | 2k | — | ~3.3k | Automated safety check: Pass | MIT | |
| Patient Recruitment Ad Genaipoch/medical-research-skills | 2k | — | ~2.7k | Automated safety check: Pass | MIT |
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Questions about Ct Status Diff
What does Ct Status Diff do?
Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Ct Status Diff is an agent skill from agentii-ai/agentii-investment-intelligence. Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03).
When should I use Ct Status Diff?
Ct Status Diff fits situations like: tasks that involve Recruiting and HR; tasks that involve Clinical and healthcare research.
How do I install Ct Status Diff in Claude Code?
Run `npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a claude-code`. Or copy the skill folder (plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff in agentii-ai/agentii-investment-intelligence) into .claude/skills/ct-status-diff in your project. Claude Code loads it when a task matches its description.
How do I install Ct Status Diff in Codex?
Run `npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a codex`. Or copy the skill folder (plugins/vertical-plugins/bio-pharm/skills/agentii/ct-status-diff in agentii-ai/agentii-investment-intelligence) into .agents/skills/ct-status-diff in your project. Codex loads it when a task matches its description.
Can I use Ct Status Diff in Cursor, Gemini CLI or GitHub Copilot?
Cursor, Gemini CLI, GitHub Copilot and OpenCode also load SKILL.md folders. With the skills CLI, run `npx skills add agentii-ai/agentii-investment-intelligence --skill ct-status-diff -a cursor` (or -a gemini-cli, github-copilot or opencode for the others). To copy it by hand, put the folder in .cursor/skills/ct-status-diff, .gemini/skills/ct-status-diff, .github/skills/ct-status-diff and .opencode/skills/ct-status-diff in your project.
What does Ct Status Diff need to run?
SKILL.md names no scripts, command-line tools or credentials: Ct Status Diff is instructions for the agent only.
Does Ct Status Diff access the network?
SKILL.md contains no URLs. Any network use would come from the scripts or tools the agent runs. This is read from the text; nothing was executed.
Is Ct Status Diff safe to install?
Our automated static check of SKILL.md found no risky patterns, such as piping downloads into a shell, reading credential files or hidden Unicode. It is not a guarantee. Review the folder before installing.
What licence does Ct Status Diff use?
Ct Status Diff is published under the Apache-2.0 licence (the repository's licence). It allows redistribution, so the full SKILL.md is shown on this page.
How many tokens does Ct Status Diff use?
About 1.8k tokens (SKILL.md is roughly 7.2k characters). Agents keep only the skill's name and description in context until a task matches; then they load SKILL.md in full. Its references folder adds about 675 tokens, read only when the agent opens those files.
What are the alternatives to Ct Status Diff?
Skills that share tags, products or a category with Ct Status Diff: Searching Clinicaltrials (maziyarpanahi/openmed, 5.5k stars), Clinicaltrials DB (aipoch/medical-research-skills, 2k stars), Clinical Trials Database (google-deepmind/science-skills, 3.2k stars) and Inclusion Criteria Gen (aipoch/medical-research-skills, 2k stars). The comparison table on this page puts their stars, adoption, token cost, safety result and licence side by side.
Who maintains Ct Status Diff?
agentii-ai (a GitHub user) maintains it in agentii-ai/agentii-investment-intelligence, which has 207 GitHub stars. The repository holds 79 skills in this directory. The repository was last updated on September 29, 2026.
Source: agentii-ai/agentii-investment-intelligence on GitHub. Facts on this page come from the repository at the commit we read; the author's words are quoted as theirs.